Research laboratory of Leslie Benet, PhD

Publications

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2011–Now

  1. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Lancet HIV. 2016 Aug 31. PMID: 27658870.
    View in: PubMed

  2. Bowman CM, Benet LZ. Hepatic clearance predictions from in vitro-in vivo extrapolation and BDDCS. Drug Metab Dispos. 2016 Aug 12. PMID: 27519549.
    View in: PubMed

  3. Benet LZ. 2016 Remington Honor Medal Address: Science for the profession. J Am Pharm Assoc (2003). 2016 Jul-Aug; 56(4):365-8. PMID: 27450136.
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  4. Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Int J Tuberc Lung Dis. 2016 Jun; 20(6):844-7. PMID: 27155191.
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  5. Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and drugability. Adv Drug Deliv Rev. 2016 Jun 1; 101:89-98. PMID: 27182629.
    View in: PubMed

  6. Burmeister Getz E, Carroll KJ, Jones B, Benet LZ. Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial. Clin Pharmacol Ther. 2016 Sep; 100(3):223-31. PMID: 27037630.
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  7. Chan R, Wei CY, Chen YT, Benet LZ. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. AAPS J. 2016 May; 18(3):757-66. PMID: 26951484.
    View in: PubMed

  8. Zheng Y, Chen X, Benet LZ. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clin Pharmacokinet. 2016 Feb; 55(2):143-67. PMID: 26293617.
    View in: PubMed

  9. Hosey CM, Chan R, Benet LZ. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. AAPS J. 2016 Jan; 18(1):251-60. PMID: 26589308.
    View in: PubMed

  10. Parasrampuria DA, Benet LZ. Response of authors to Ganju and Dias' comments on 'Inclusion of Placebos and Blinding for Ascending Dose First-in-Human Studies and Other Underpowered Phase 1 Studies Has Not Been Justified and on Balance is Not Useful' by D. A. Parasrampuria and L. Z. Benet. Basic Clin Pharmacol Toxicol. 2015 Dec; 117(6):367. PMID: 26435387.
    View in: PubMed

  11. Garrison KL, Sahin S, Benet LZ. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. J Pharm Sci. 2015 Sep; 104(9):3229-35. PMID: 26010239; PMCID: PMC4536115 [Available on 09/01/16].
    View in: PubMed, PubMed Central

  12. Hosey CM, Benet LZ. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Mol Pharm. 2015 May 4; 12(5):1456-66. PMID: 25816851; PMCID: PMC4666302.
    View in: PubMed, PubMed Central

  13. Zheng Y, Benet LZ, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharm Res. 2015 Aug; 32(8):2516-26. PMID: 25690341.
    View in: PubMed

  14. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2015 Jun; 15(6):377-83. PMID: 25776193.
    View in: PubMed

  15. Parasrampuria DA, Benet LZ. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Basic Clin Pharmacol Toxicol. 2015 Jul; 117(1):44-51. PMID: 25406995.
    View in: PubMed

  16. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 Nov; 16(6):1358-65. PMID: 25274610; PMCID: PMC4389759.
    View in: PubMed, PubMed Central

  17. Hosey CM, Broccatelli F, Benet LZ. Predicting when biliary excretion of parent drug is a major route of elimination in humans. AAPS J. 2014 Sep; 16(5):1085-96. PMID: 25004821; PMCID: PMC4147063.
    View in: PubMed, PubMed Central

  18. Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Mol Pharm. 2014 Apr 7; 11(4):1335-44. PMID: 24628254; PMCID: PMC3983369.
    View in: PubMed, PubMed Central

  19. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. PMID: 24389906; PMCID: PMC4018220.
    View in: PubMed, PubMed Central

  20. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 3; 508(7494):93-7. PMID: 24572354; PMCID: PMC4161230.
    View in: PubMed, PubMed Central

  21. Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Mol Pharm. 2013 Nov 4; 10(11):4055-62. PMID: 24044612.
    View in: PubMed

  22. Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Mol Pharm. 2013 Nov 4; 10(11):4038-45. PMID: 24044638.
    View in: PubMed

  23. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. PMID: 24030928; PMCID: PMC4018225.
    View in: PubMed, PubMed Central

  24. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4; 10(11):4032-7. PMID: 23980906; PMCID: PMC3946491.
    View in: PubMed, PubMed Central

  25. Horng H, Benet LZ. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metab Dispos. 2013 Nov; 41(11):1923-33. PMID: 23975029; PMCID: PMC3807055.
    View in: PubMed, PubMed Central

  26. Horng H, Benet LZ. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chem Res Toxicol. 2013 Mar 18; 26(3):465-76. PMID: 23402341; PMCID: PMC3626286.
    View in: PubMed, PubMed Central

  27. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. PMID: 23417511; PMCID: PMC3640342.
    View in: PubMed, PubMed Central

  28. Larregieu CA, Benet LZ. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. AAPS J. 2013 Apr; 15(2):483-97. PMID: 23344793; PMCID: PMC3675726.
    View in: PubMed, PubMed Central

  29. Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. J Pharm Sci. 2013 Jan; 102(1):34-42. PMID: 23147500; PMCID: PMC3684558.
    View in: PubMed, PubMed Central

  30. Benet LZ. A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates. Clin Pharmacol Ther. 2012 Nov; 92(5):551-2. PMID: 23085879.
    View in: PubMed

  31. Budha NR, Benet LZ, Ware JA. Response to "Drug interactions produced by proton pump inhibitors: not simply a pH effect". Clin Pharmacol Ther. 2013 Feb; 93(2):151. PMID: 23169432.
    View in: PubMed

  32. Estudante M, Morais JG, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Adv Drug Deliv Rev. 2013 Oct; 65(10):1340-56. PMID: 23041352.
    View in: PubMed

  33. Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy? Clin Pharmacol Ther. 2012 Aug; 92(2):203-13. PMID: 22739140.
    View in: PubMed

  34. Benet LZ. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. AAPS J. 2012 Jun; 14(2):164-7. PMID: 22302585; PMCID: PMC3326156.
    View in: PubMed, PubMed Central

  35. Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharm Res. 2012 Jul; 29(7):1768-74. PMID: 22350803; PMCID: PMC4167886.
    View in: PubMed, PubMed Central

  36. Broccatelli F, Cruciani G, Benet LZ, Oprea TI. BDDCS class prediction for new molecular entities. Mol Pharm. 2012 Mar 5; 9(3):570-80. PMID: 22224483; PMCID: PMC3295927.
    View in: PubMed, PubMed Central

  37. Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan; 64(1):95-109. PMID: 22261306; PMCID: PMC3496430.
    View in: PubMed, PubMed Central

  38. Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Pharmacotherapy. 2011 Sep; 31(9):871-6. PMID: 21923588; PMCID: PMC3727161.
    View in: PubMed, PubMed Central

  39. Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metab Dispos. 2011 Nov; 39(11):2017-9. PMID: 21849516; PMCID: PMC3198899.
    View in: PubMed, PubMed Central

  40. Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. AAPS J. 2011 Dec; 13(4):519-47. PMID: 21818695; PMCID: PMC3231854.
    View in: PubMed, PubMed Central

  41. Terasaki T, Sugiyama Y, Benet LZ. Professor Akira Tsuji: scientist, educator, and leader. J Pharm Sci. 2011 Sep; 100(9):3541-6. PMID: 21630279.
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  42. Rowland M, Benet LZ. Lead PK commentary: predicting human pharmacokinetics. J Pharm Sci. 2011 Oct; 100(10):4047-9. PMID: 21630278.
    View in: PubMed

  43. Reyes M, Benet LZ. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. J Pharm Sci. 2011 Sep; 100(9):3831-42. PMID: 21618544; PMCID: PMC3581075.
    View in: PubMed, PubMed Central

  44. Grover A, Benet LZ. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. J Pharmacokinet Pharmacodyn. 2011 Jun; 38(3):369-83. PMID: 21499748; PMCID: PMC3677834.
    View in: PubMed, PubMed Central

  45. Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Pharm Res. 2011 Jul; 28(7):1774-8. PMID: 21491148.
    View in: PubMed

  46. Park MS, Okochi H, Benet LZ. Is Ciprofloxacin a Substrate of P-glycoprotein? Arch Drug Inf. 2011 Mar; 4(1):1-9. PMID: 21572514.
    View in: PubMed

2001–2010

  1. Aarons L, Benet LZ. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):525-7. PMID: 21069561.
    View in: PubMed

  2. Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. J Pharmacokinet Pharmacodyn. 2010 Dec; 37(6):529-39. PMID: 21113650; PMCID: PMC3005114.
    View in: PubMed, PubMed Central

  3. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7. PMID: 21075140.
    View in: PubMed

  4. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Clin Pharmacol Ther. 2010 Oct; 88(4):540-7. PMID: 20703222; PMCID: PMC3091944.
    View in: PubMed, PubMed Central

  5. Benet LZ, Larregieu CA. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clin Pharmacol Ther. 2010 Sep; 88(3):405-7. PMID: 20668447; PMCID: PMC4169211.
    View in: PubMed, PubMed Central

  6. Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B. Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation. Clin Ther. 2010 Mar; 32(3):534-42. PMID: 20399990; PMCID: PMC3097025.
    View in: PubMed, PubMed Central

  7. Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, Lee CA, Niemi M, Polli JW, Sugiyama Y, Swaan PW, Ware JA, Wright SH, Yee SW, Zamek-Gliszczynski MJ, Zhang L. Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar; 9(3):215-36. PMID: 20190787; PMCID: PMC3326076.
    View in: PubMed, PubMed Central

  8. Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Clin Pharmacol Ther. 2010 Apr; 87(4):465-72. PMID: 20090676; PMCID: PMC3581054.
    View in: PubMed, PubMed Central

  9. Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metab Dispos. 2010 Jan; 38(1):133-42. PMID: 19786506; PMCID: PMC2802421.
    View in: PubMed, PubMed Central

  10. Benet LZ. Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System. Basic Clin Pharmacol Toxicol. 2010 Mar; 106(3):162-7. PMID: 20002064; PMCID: PMC3564954.
    View in: PubMed, PubMed Central

  11. de Souza J, Benet LZ, Huang Y, Storpirtis S. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. J Pharm Sci. 2009 Nov; 98(11):4413-9. PMID: 19472342.
    View in: PubMed

  12. Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Mol Pharm. 2009 Nov-Dec; 6(6):1631-43. PMID: 19874004; PMCID: PMC2796475.
    View in: PubMed, PubMed Central

  13. Benet LZ. A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient. Clin Pharmacol Ther. 2009 Aug; 86(2):133-4. PMID: 19621007.
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  14. Shugarts S, Benet LZ. The role of transporters in the pharmacokinetics of orally administered drugs. Pharm Res. 2009 Sep; 26(9):2039-54. PMID: 19568696; PMCID: PMC2719753.
    View in: PubMed, PubMed Central

  15. Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ. Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate. Pediatr Infect Dis J. 2009 May; 28(5):398-402. PMID: 19295465; PMCID: PMC3101254.
    View in: PubMed, PubMed Central

  16. Grover A, Benet LZ. Effects of drug transporters on volume of distribution. AAPS J. 2009 Jun; 11(2):250-61. PMID: 19399628; PMCID: PMC2691462.
    View in: PubMed, PubMed Central

  17. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. J Acquir Immune Defic Syndr. 2009 Apr 15; 50(5):482-91. PMID: 19408353; PMCID: PMC2700138.
    View in: PubMed, PubMed Central

  18. Sahin S, Benet LZ. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Pharm Res. 2008 Dec; 25(12):2869-77. PMID: 19015955; PMCID: PMC3581066.
    View in: PubMed, PubMed Central

  19. Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Clin Pharmacol Ther. 2009 Jan; 85(1):78-85. PMID: 18843263; PMCID: PMC3582657.
    View in: PubMed, PubMed Central

  20. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2008; 2(5):379-83. PMID: 19745507.
    View in: PubMed

  21. Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol. 2008 Oct; 21(10):1933-8. PMID: 18693772.
    View in: PubMed

  22. Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Pharm Res. 2008 Mar; 25(3):483-8. PMID: 18236138; PMCID: PMC3580995.
    View in: PubMed, PubMed Central

  23. Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metab Dispos. 2008 Apr; 36(4):682-7. PMID: 18187563.
    View in: PubMed

  24. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant. 2008 Feb; 8(2):355-65. PMID: 18093266.
    View in: PubMed

  25. Custodio JM, Wu CY, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Adv Drug Deliv Rev. 2008 Mar 17; 60(6):717-33. PMID: 18199522; PMCID: PMC2292816.
    View in: PubMed, PubMed Central

  26. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. PMID: 17949460.
    View in: PubMed

  27. Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. J Mass Spectrom. 2007 Jun; 42(6):793-802. PMID: 17511017.
    View in: PubMed

  28. Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Clin Pharmacol Ther. 2007 Jun; 81(6):828-32. PMID: 17361125.
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  29. Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Drug Metab Dispos. 2007 May; 35(5):758-64. PMID: 17303625.
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  30. Benet LZ. Review and critique of the Institute of Medicine report "the future of drug safety". Clin Pharmacol Ther. 2007 Feb; 81(2):158-61. PMID: 17259941.
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  31. Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther. 2007 Feb; 81(2):194-204. PMID: 17192770.
    View in: PubMed

  32. Lam JL, Shugarts SB, Okochi H, Benet LZ. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. J Pharmacol Exp Ther. 2006 Nov; 319(2):864-70. PMID: 16905688.
    View in: PubMed

  33. Lam JL, Okochi H, Huang Y, Benet LZ. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metab Dispos. 2006 Aug; 34(8):1336-44. PMID: 16698890.
    View in: PubMed

  34. Lau YY, Okochi H, Huang Y, Benet LZ. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Drug Metab Dispos. 2006 Jul; 34(7):1175-81. PMID: 16624870.
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  35. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul; 34(7):1136-44. PMID: 16581945.
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  36. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Rapid Commun Mass Spectrom. 2006; 20(10):1611-4. PMID: 16628600.
    View in: PubMed

  37. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. PMID: 16304193; PMCID: PMC1315979.
    View in: PubMed, PubMed Central

  38. Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chem Res Toxicol. 2005 Nov; 18(11):1729-36. PMID: 16300382.
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  39. Lau YY, Okochi H, Huang Y, Benet LZ. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. J Pharmacol Exp Ther. 2006 Feb; 316(2):762-71. PMID: 16258024.
    View in: PubMed

  40. Chang JH, Benet LZ. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Mol Pharm. 2005 Sep-Oct; 2(5):428-34. PMID: 16196496.
    View in: PubMed

  41. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacol Ther. 2006 Jan; 109(1-2):1-11. PMID: 16085315.
    View in: PubMed

  42. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Nephrology (Carlton). 2005 Aug; 10(4):393-9. PMID: 16109088.
    View in: PubMed

  43. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. PMID: 16003227.
    View in: PubMed

  44. Benet LZ. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Mol Interv. 2005 Apr; 5(2):79-83. PMID: 15821156.
    View in: PubMed

  45. Putnam WS, Woo JM, Huang Y, Benet LZ. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. J Clin Pharmacol. 2005 Apr; 45(4):411-21. PMID: 15778422.
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  46. Benet L. Basic pharmacological interactions and how they may impact on one another. J Acquir Immune Defic Syndr. 2005 Mar; 38 Suppl 1:S22-3. PMID: 15867606.
    View in: PubMed

  47. Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res. 2005 Jan; 22(1):11-23. PMID: 15771225.
    View in: PubMed

  48. Mohri K, Okada K, Benet LZ. Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Pharm Res. 2005 Jan; 22(1):79-85. PMID: 15771233.
    View in: PubMed

  49. Lam JL, Benet LZ. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metab Dispos. 2004 Nov; 32(11):1311-6. PMID: 15483198.
    View in: PubMed

  50. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit. 2004 Oct; 26(5):546-62. PMID: 15385839.
    View in: PubMed

  51. Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Catheter Cardiovasc Interv. 2004 Oct; 63(2):222-30. PMID: 15390346.
    View in: PubMed

  52. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96. PMID: 15339861; PMCID: PMC1575349.
    View in: PubMed, PubMed Central

  53. Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metab Dispos. 2004 Nov; 32(11):1239-46. PMID: 15286055.
    View in: PubMed

  54. Kim WY, Benet LZ. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul; 21(7):1284-93. PMID: 15290871.
    View in: PubMed

  55. Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int J Pharm. 2004 Jun 11; 277(1-2):3-9. PMID: 15158963.
    View in: PubMed

  56. Frassetto LA, Benet LZ. Pharmacogenomics and transplantation: where are we? Am J Transplant. 2004 Jun; 4(6):843. PMID: 15147415.
    View in: PubMed

  57. Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107. PMID: 15087483.
    View in: PubMed

  58. Lau YY, Wu CY, Okochi H, Benet LZ. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. J Pharmacol Exp Ther. 2004 Mar; 308(3):1040-5. PMID: 14634033.
    View in: PubMed

  59. Wu CY, Benet LZ. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metab Dispos. 2003 Nov; 31(11):1292-5. PMID: 14570757.
    View in: PubMed

  60. Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan; 308(1):143-55. PMID: 14569063.
    View in: PubMed

  61. Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Curr Drug Metab. 2003 Oct; 4(5):393-8. PMID: 14529371.
    View in: PubMed

  62. Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Drug Metab Dispos. 2003 Jun; 31(6):727-30. PMID: 12756204.
    View in: PubMed

  63. Li C, Grillo MP, Benet LZ. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. J Pharmacol Exp Ther. 2003 Apr; 305(1):250-6. PMID: 12649376.
    View in: PubMed

  64. Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther. 2003 Apr; 305(1):306-14. PMID: 12649383.
    View in: PubMed

  65. Li C, Grillo MP, Benet LZ. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Toxicol Appl Pharmacol. 2003 Mar 1; 187(2):101-9. PMID: 12649042.
    View in: PubMed

  66. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. PMID: 15618725.
    View in: PubMed

  67. Hebert MF, Wacher VJ, Roberts JP, Benet LZ. Pharmacokinetics of cyclosporine pre- and post-liver transplantation. J Clin Pharmacol. 2003 Jan; 43(1):38-42. PMID: 12520626.
    View in: PubMed

  68. Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Med. 2002 Dec; 68(12):1055-8. PMID: 12494328.
    View in: PubMed

  69. Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. J Pharm Sci. 2002 Dec; 91(12):2622-35. PMID: 12434407.
    View in: PubMed

  70. Li C, Benet LZ, Grillo MP. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. Chem Res Toxicol. 2002 Nov; 15(11):1480-7. PMID: 12437340.
    View in: PubMed

  71. Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clin Pharmacol Ther. 2002 Nov; 72(5):474-89. PMID: 12426511.
    View in: PubMed

  72. Li C, Benet LZ, Grillo MP. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. Chem Res Toxicol. 2002 Oct; 15(10):1309-17. PMID: 12387630.
    View in: PubMed

  73. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J Pharmacol Exp Ther. 2002 Sep; 302(3):1123-8. PMID: 12183671.
    View in: PubMed

  74. Flanagan SD, Takahashi LH, Liu X, Benet LZ. Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells. J Pharm Sci. 2002 Apr; 91(4):1169-77. PMID: 11948555.
    View in: PubMed

  75. Susanto M, Benet LZ. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res. 2002 Apr; 19(4):457-62. PMID: 12033380.
    View in: PubMed

  76. Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J Pharmacol Exp Ther. 2002 Mar; 300(3):1036-45. PMID: 11861813.
    View in: PubMed

  77. Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. J Clin Pharmacol. 2002 Mar; 42(3):304-11. PMID: 11865967.
    View in: PubMed

  78. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. PMID: 11891440.
    View in: PubMed

  79. Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Ther. 2002 Mar; 71(3):115-21. PMID: 11907485.
    View in: PubMed

  80. Unger M, Jacobsen W, Holzgrabe U, Benet LZ. Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Feb 15; 767(2):245-53. PMID: 11885853.
    View in: PubMed

  81. Grillo MP, Benet LZ. Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro. Drug Metab Dispos. 2002 Jan; 30(1):55-62. PMID: 11744612.
    View in: PubMed

  82. Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharm Res. 2002 Jan; 19(1):27-33. PMID: 11837697.
    View in: PubMed

  83. Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 2002; 64(3):126-34. PMID: 11834888.
    View in: PubMed

  84. Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet. 2002; 41(11):813-51. PMID: 12190331.
    View in: PubMed

  85. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clin Pharmacol Ther. 2001 Nov; 70(5):462-7. PMID: 11719733.
    View in: PubMed

  86. Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Adv Drug Deliv Rev. 2001 Oct 1; 50 Suppl 1:S3-11. PMID: 11576692.
    View in: PubMed

  87. Grillo MP, Chiellini G, Tonelli M, Benet LZ. Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats. Drug Metab Dispos. 2001 Sep; 29(9):1210-5. PMID: 11502730.
    View in: PubMed

  88. Grillo MP, Benet LZ. Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat. Chem Res Toxicol. 2001 Aug; 14(8):1033-40. PMID: 11511177.
    View in: PubMed

  89. Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharm Res. 2001 Aug; 18(8):1102-9. PMID: 11587480.
    View in: PubMed

  90. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol. 2001 Jul; 133(6):875-85. PMID: 11454661; PMCID: PMC1572850.
    View in: PubMed, PubMed Central

  91. Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J Med Chem. 2001 Jun 7; 44(12):2027-34. PMID: 11384247.
    View in: PubMed

  92. Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev. 2001 Mar 1; 46(1-3):89-102. PMID: 11259835.
    View in: PubMed

  93. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc. 2001 Feb-Mar; 33(1-2):514-5. PMID: 11266932.
    View in: PubMed

  94. Qiu Y, Benet LZ, Burlingame AL. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry. Adv Exp Med Biol. 2001; 500:663-73. PMID: 11765013.
    View in: PubMed

  95. Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet. 2001; 40(3):159-68. PMID: 11327196.
    View in: PubMed

  96. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clin Pharmacol Ther. 2001 Jan; 69(1):24-31. PMID: 11180035.
    View in: PubMed

  97. Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharm Res. 2001 Jan; 18(1):39-44. PMID: 11336351.
    View in: PubMed

1991–2000

  1. Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ. Chiral bioequivalence: effect of absorption rate on racemic etodolac. Clin Pharmacokinet. 2000 Dec; 39(6):459-69. PMID: 11192477.
    View in: PubMed

  2. Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov; 28(11):1343-51. PMID: 11038163.
    View in: PubMed

  3. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos. 2000 Nov; 28(11):1369-78. PMID: 11038166.
    View in: PubMed

  4. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl. 2000 Oct 1; 748(1):41-53. PMID: 11092585.
    View in: PubMed

  5. Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther. 2000 Jul; 294(1):323-32. PMID: 10871329.
    View in: PubMed

  6. Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited. Ther Drug Monit. 2000 Jun; 22(3):330-45. PMID: 10850403.
    View in: PubMed

  7. Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar; 129(6):1235-43. PMID: 10725273; PMCID: PMC1571937.
    View in: PubMed, PubMed Central

  8. Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol. 2000 Feb; 129(3):485-92. PMID: 10711346; PMCID: PMC1571863.
    View in: PubMed, PubMed Central

  9. Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE. Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation. 2000 Jan 15; 69(1):76-86. PMID: 10653384.
    View in: PubMed

  10. Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Drug Metab Dispos. 1999 Dec; 27(12):1505-11. PMID: 10570034.
    View in: PubMed

  11. Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. J Control Release. 1999 Nov 1; 62(1-2):25-31. PMID: 10518631.
    View in: PubMed

  12. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. J Pharmacol Exp Ther. 1999 Oct; 291(1):131-9. PMID: 10490896.
    View in: PubMed

  13. Mizuma T, McDonagh AF, Lin ET, Benet LZ. Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin. Br J Clin Pharmacol. 1999 Jul; 48(1):79-87. PMID: 10383564; PMCID: PMC2014883.
    View in: PubMed, PubMed Central

  14. Benet LZ. Relevance of pharmacokinetics in narrow therapeutic index drugs. Transplant Proc. 1999 May; 31(3):1642-4; discussion 1675-84. PMID: 10331032.
    View in: PubMed

  15. Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther. 1999 May; 289(2):800-6. PMID: 10215655.
    View in: PubMed

  16. Benet LZ. Understanding bioequivalence testing. Transplant Proc. 1999 May; 31(3A Suppl):7S-9S. PMID: 10330950.
    View in: PubMed

  17. Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment. Transplantation. 1999 Apr 15; 67(7):956-62. PMID: 10221478.
    View in: PubMed

  18. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr; 16(4):478-85. PMID: 10227700.
    View in: PubMed

  19. Mizuma T, Benet LZ, Lin ET. Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite. Biopharm Drug Dispos. 1999 Apr; 20(3):131-6. PMID: 10211865.
    View in: PubMed

  20. Zhang Y, Guo X, Lin ET, Benet LZ. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes. Pharmacology. 1999 Mar; 58(3):147-59. PMID: 9925971.
    View in: PubMed

  21. Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA. Molecular and physical mechanisms of first-pass extraction. Drug Metab Dispos. 1999 Feb; 27(2):161-6. PMID: 9929497.
    View in: PubMed

  22. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb; 27(2):173-9. PMID: 9929499.
    View in: PubMed

  23. Salphati L, Benet LZ. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica. 1999 Feb; 29(2):171-85. PMID: 10199593.
    View in: PubMed

  24. Flanagan SD, Benet LZ. Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum. Pharm Res. 1999 Feb; 16(2):221-24. PMID: 10100306.
    View in: PubMed

  25. Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. J Chromatogr B Biomed Sci Appl. 1998 Dec 11; 720(1-2):179-87. PMID: 9892080.
    View in: PubMed

  26. Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. J Clin Pharmacol. 1998 Dec; 38(12):1137-43. PMID: 11301566.
    View in: PubMed

  27. Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. J Pharm Sci. 1998 Nov; 87(11):1322-30. PMID: 9811484.
    View in: PubMed

  28. Mizuma T, Benet LZ, Lin ET. High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide. J Chromatogr B Biomed Sci Appl. 1998 Oct 23; 718(1):153-62. PMID: 9832372.
    View in: PubMed

  29. Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats. J Pharmacol Exp Ther. 1998 Oct; 287(1):246-52. PMID: 9765344.
    View in: PubMed

  30. Zhang Y, Benet LZ. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers. Pharm Res. 1998 Oct; 15(10):1520-4. PMID: 9794492.
    View in: PubMed

  31. Benet LZ. Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation. Transplant Proc. 1998 Aug; 30(5):1650-1. PMID: 9723227.
    View in: PubMed

  32. Qiu Y, Benet LZ, Burlingame AL. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. J Biol Chem. 1998 Jul 10; 273(28):17940-53. PMID: 9651401.
    View in: PubMed

  33. Salphati L, Benet LZ. Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology. 1998 Jun; 56(6):308-13. PMID: 9654217.
    View in: PubMed

  34. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther. 1998 Jun; 285(3):1104-12. PMID: 9618413.
    View in: PubMed

  35. Mohri K, Okada K, Benet LZ. Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide. Drug Metab Dispos. 1998 Apr; 26(4):332-7. PMID: 9531520.
    View in: PubMed

  36. Zhang Y, Guo X, Lin ET, Benet LZ. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug Metab Dispos. 1998 Apr; 26(4):360-6. PMID: 9531525.
    View in: PubMed

  37. Qiu Y, Burlingame AL, Benet LZ. Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry. Drug Metab Dispos. 1998 Mar; 26(3):246-56. PMID: 9492388.
    View in: PubMed

  38. Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharmacology. 1998 Mar; 56(3):150-7. PMID: 9532615.
    View in: PubMed

  39. Salphati L, Benet LZ. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem Pharmacol. 1998 Feb 15; 55(4):387-95. PMID: 9514072.
    View in: PubMed

  40. Mizuma T, Benet LZ, Lin ET. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides. Prep Biochem Biotechnol. 1998 Feb; 28(1):37-47. PMID: 9516641.
    View in: PubMed

  41. Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. J Pharmacokinet Biopharm. 1997 Dec; 25(6):647-72. PMID: 9697076.
    View in: PubMed

  42. Jang GR, Benet LZ. Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. Drug Metab Dispos. 1997 Oct; 25(10):1119-22. PMID: 9321513.
    View in: PubMed

  43. Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther. 1997 Sep; 62(3):248-60. PMID: 9333100.
    View in: PubMed

  44. Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clin Pharmacol Ther. 1997 Jul; 62(1):41-9. PMID: 9246018.
    View in: PubMed

  45. Yuan R, Sumi M, Benet LZ. Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo. J Pharmacol Exp Ther. 1997 Jun; 281(3):1499-505. PMID: 9190888.
    View in: PubMed

  46. Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET. Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):133-40. PMID: 9187392.
    View in: PubMed

  47. Wu ST, Benet LZ, Lin ET. Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection. J Chromatogr B Biomed Sci Appl. 1997 Apr 25; 692(1):149-56. PMID: 9187394.
    View in: PubMed

  48. Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. J Clin Pharmacol. 1996 Nov; 36(11):1012-21. PMID: 8973990.
    View in: PubMed

  49. Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL. Evaluation of orally administered highly variable drugs and drug formulations. Pharm Res. 1996 Nov; 13(11):1590-4. PMID: 8956322.
    View in: PubMed

  50. Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. Br J Clin Pharmacol. 1996 Oct; 42(4):510-2. PMID: 8904626.
    View in: PubMed

  51. Benet LZ. Morality play. Science. 1996 Sep 27; 273(5283):1782; author reply 1784-5. PMID: 8815536.
    View in: PubMed

  52. Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochem Pharmacol. 1996 Sep 13; 52(5):753-61. PMID: 8765473.
    View in: PubMed

  53. Haj-Yehia AI, Benet LZ. In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance. J Pharmacol Exp Ther. 1996 Sep; 278(3):1296-305. PMID: 8819515.
    View in: PubMed

  54. Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ. Acute dose-dependent disposition studies of nicotinic acid in rats. Drug Metab Dispos. 1996 Jul; 24(7):773-9. PMID: 8818575.
    View in: PubMed

  55. Kenkare SR, Benet LZ. Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases. Biochem Pharmacol. 1996 May 17; 51(10):1357-63. PMID: 8787552.
    View in: PubMed

  56. Berg-Candolfi M, Candolfi E, Benet LZ. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica. 1996 Apr; 26(4):381-94. PMID: 9173679.
    View in: PubMed

  57. Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ. The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. Clin Pharmacol Ther. 1996 Apr; 59(4):429-35. PMID: 8612388.
    View in: PubMed

  58. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther. 1996 Mar; 59(3):297-303. PMID: 8653992.
    View in: PubMed

  59. Jaeger W, Benet LZ, Bornheim LM. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica. 1996 Mar; 26(3):275-84. PMID: 8730919.
    View in: PubMed

  60. Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol. 1995 Nov; 35(11):1094-102. PMID: 8626883.
    View in: PubMed

  61. Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clin Pharmacol Ther. 1995 Nov; 58(5):492-7. PMID: 7586942.
    View in: PubMed

  62. Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ. Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac. Biochem J. 1995 Oct 15; 311 ( Pt 2):431-5. PMID: 7487878; PMCID: PMC1136018.
    View in: PubMed, PubMed Central

  63. Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct; 23(10):1099-103. PMID: 8654198.
    View in: PubMed

  64. d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ. Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation. J Clin Pharmacol. 1995 Oct; 35(10):967-73. PMID: 8568014.
    View in: PubMed

  65. Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug Metab Dispos. 1995 Sep; 23(9):900-3. PMID: 8565778.
    View in: PubMed

  66. Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ. Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain. Drug Metab Dispos. 1995 Aug; 23(8):825-31. PMID: 7493549.
    View in: PubMed

  67. Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ. Stereoselective binding properties of naproxen glucuronide diastereomers to proteins. J Pharmacokinet Biopharm. 1995 Aug; 23(4):379-95. PMID: 8882746.
    View in: PubMed

  68. Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs. 1995 Aug; 50(2):222-39. PMID: 8521756.
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  69. Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog. 1995 Jul; 13(3):129-34. PMID: 7619215.
    View in: PubMed

  70. Benet LZ, Goyan JE. Bioequivalence and narrow therapeutic index drugs. Pharmacotherapy. 1995 Jul-Aug; 15(4):433-40. PMID: 7479195.
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  71. Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clin Pharmacol Ther. 1995 Jul; 58(1):15-9. PMID: 7628178.
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  72. Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharm Drug Dispos. 1995 May; 16(4):303-12. PMID: 7548779.
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  73. Haj-Yehia AI, Benet LZ. 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 7; 666(1):45-53. PMID: 7655620.
    View in: PubMed

  74. Haj-Yehia AI, Benet LZ. Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats. J Pharmacol Exp Ther. 1995 Apr; 273(1):94-100. PMID: 7714819.
    View in: PubMed

  75. Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ. Biliary excretion of furosemide glucuronide in rabbits. Biol Pharm Bull. 1995 Mar; 18(3):447-53. PMID: 7550101.
    View in: PubMed

  76. Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ. Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry. Drug Metab Dispos. 1995 Mar; 23(3):369-76. PMID: 7628303.
    View in: PubMed

  77. Benet LZ, Zia-Amirhosseini P. Basic principles of pharmacokinetics. Toxicol Pathol. 1995 Mar-Apr; 23(2):115-23. PMID: 7569664.
    View in: PubMed

  78. Sekikawa H, Yagi N, Lin ET, Benet LZ. Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution. Biol Pharm Bull. 1995 Jan; 18(1):134-9. PMID: 7735228.
    View in: PubMed

  79. Haj-Yehia AI, Benet LZ. Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole. Pharm Res. 1995 Jan; 12(1):155-60. PMID: 7724479.
    View in: PubMed

  80. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nat Med. 1995 Jan; 1(1):2-4. PMID: 7584944.
    View in: PubMed

  81. Kenkare SR, Han C, Benet LZ. Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase. Biochem Pharmacol. 1994 Dec 16; 48(12):2231-5. PMID: 7811305.
    View in: PubMed

  82. Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ. Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction. J Chromatogr B Biomed Appl. 1994 Nov 4; 661(1):154-8. PMID: 7866544.
    View in: PubMed

  83. Perotti BY, Prueksaritanont T, Benet LZ. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharm Res. 1994 Jun; 11(6):844-7. PMID: 7524055.
    View in: PubMed

  84. Ojingwa JC, Spahn-Langguth H, Benet LZ. Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica. 1994 Jun; 24(6):495-506. PMID: 7975715.
    View in: PubMed

  85. Gustavson LE, Benet LZ. Menopause: pharmacodynamics and pharmacokinetics. Exp Gerontol. 1994 May-Aug; 29(3-4):437-44. PMID: 7925762.
    View in: PubMed

  86. Han C, Jung P, Sanders SW, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharm Drug Dispos. 1994 Mar; 15(2):179-83. PMID: 8011969.
    View in: PubMed

  87. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. J Clin Pharmacol. 1994 Feb; 34(2):111-9. PMID: 8163710.
    View in: PubMed

  88. Ojingwa JC, Spahn-Langguth H, Benet LZ. Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. J Pharmacokinet Biopharm. 1994 Feb; 22(1):19-40. PMID: 8027947.
    View in: PubMed

  89. Benet LZ, Zech K. Pharmacokinetics--a relevant factor for the choice of a drug? Aliment Pharmacol Ther. 1994; 8 Suppl 1:25-32. PMID: 8180291.
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  90. Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ. Bioactivation by glucuronide-conjugate formation. Adv Pharmacol. 1994; 27:385-97. PMID: 8068561.
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  91. Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ. FK 506 metabolism in male and female rat liver microsomes. Drug Metab Dispos. 1994 Jan-Feb; 22(1):85-9. PMID: 7512020.
    View in: PubMed

  92. Benet LZ. Pharmacokinetic profile of etodolac in special populations. Eur J Rheumatol Inflamm. 1994; 14(1):15-8. PMID: 7744123.
    View in: PubMed

  93. Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Clin Pharmacol Ther. 1994 Jan; 55(1):21-7. PMID: 8299313.
    View in: PubMed

  94. Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. J Clin Pharmacol. 1994 Jan; 34(1):60-7. PMID: 8132853.
    View in: PubMed

  95. Munafo A, Hyneck ML, Benet LZ. Pharmacokinetics and irreversible binding of tolmetin and its glucuronic acid esters in the elderly. Pharmacology. 1993 Nov; 47(5):309-17. PMID: 8265721.
    View in: PubMed

  96. Gumbleton M, Benet LZ. Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers. J Pharmacokinet Biopharm. 1993 Oct; 21(5):515-32. PMID: 8145129.
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  97. Lee FW, Salmonson T, Benet LZ. Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies. J Pharmacokinet Biopharm. 1993 Oct; 21(5):533-50. PMID: 8145130.
    View in: PubMed

  98. Kenkare SR, Benet LZ. Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips. Biochem Pharmacol. 1993 Jul 20; 46(2):279-84. PMID: 8394078.
    View in: PubMed

  99. Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A. Drug Metab Dispos. 1993 Jul-Aug; 21(4):730-7. PMID: 8104135.
    View in: PubMed

  100. Gupta SK, Hwang SS, Benet LZ, Gumbleton M. Interpretation and utilization of effect and concentration data collected in an in vivo pharmacokinetic and in vitro pharmacodynamic study. Pharm Res. 1993 Jun; 10(6):889-94. PMID: 8321858.
    View in: PubMed

  101. Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):3797-801. PMID: 8483897; PMCID: PMC46392.
    View in: PubMed, PubMed Central

  102. Spahn-Langguth H, Benet LZ. Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides. Pharmacology. 1993 May; 46(5):268-73. PMID: 8488171.
    View in: PubMed

  103. Lee FW, Hu J, Metzler CH, Benet LZ. Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report. J Pharmacokinet Biopharm. 1993 Apr; 21(2):163-73. PMID: 8229678.
    View in: PubMed

  104. Benet LZ. New techniques in drug metabolism and clinical pharmacology/pharmacokinetics. Am Biotechnol Lab. 1993 Feb; 11(2):44-7. PMID: 7763426.
    View in: PubMed

  105. Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET. Predictability of the covalent binding of acidic drugs in man. Life Sci. 1993; 53(8):PL141-6. PMID: 8350674.
    View in: PubMed

  106. Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H. In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. Chirality. 1993; 5(3):120-5. PMID: 8338721.
    View in: PubMed

  107. Benet LZ. Pharmacokinetics of sustained-release etodolac. Rheumatol Int. 1993; 13(2 Suppl):S3-5. PMID: 8210922.
    View in: PubMed

  108. Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clin Pharmacol Ther. 1992 Dec; 52(6):590-6. PMID: 1458768.
    View in: PubMed

  109. Lau DT, Chan EK, Benet LZ. Glutathione S-transferase-mediated metabolism of glyceryl trinitrate in subcellular fractions of bovine coronary arteries. Pharm Res. 1992 Nov; 9(11):1460-4. PMID: 1475234.
    View in: PubMed

  110. Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clin Pharmacol Ther. 1992 Nov; 52(5):453-7. PMID: 1424418.
    View in: PubMed

  111. Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J. Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin. Anesthesiology. 1992 Oct; 77(4):646-55. PMID: 1416161.
    View in: PubMed

  112. Han C, Gumbleton M, Lau DT, Benet LZ. Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites. J Chromatogr. 1992 Sep 2; 579(2):237-45. PMID: 1429971.
    View in: PubMed

  113. Prueksaritanont T, Hoener BA, Benet LZ. Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions. Drug Metab Dispos. 1992 Jul-Aug; 20(4):547-52. PMID: 1356733.
    View in: PubMed

  114. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. J Pharm Sci. 1992 Jun; 81(6):605-10. PMID: 1355792.
    View in: PubMed

  115. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Pharm Res. 1992 Jun; 9(6):826-33. PMID: 1409369.
    View in: PubMed

  116. Lau DT, Benet LZ. Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation. Biochem Pharmacol. 1992 May 28; 43(10):2247-54. PMID: 1599510.
    View in: PubMed

  117. Prueksaritanont T, Koike M, Hoener BA, Benet LZ. Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids. Biochem Pharmacol. 1992 May 8; 43(9):1997-2006. PMID: 1596287.
    View in: PubMed

  118. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clin Pharmacol Ther. 1992 Apr; 51(4):465-73. PMID: 1563216.
    View in: PubMed

  119. Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. II. Effects of skin condition and penetration enhancement. Pharm Res. 1992 Mar; 9(3):303-6. PMID: 1614960.
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  120. Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharm Res. 1992 Feb; 9(2):187-90. PMID: 1553339.
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  121. Spahn-Langguth H, Benet LZ. Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism? Drug Metab Rev. 1992; 24(1):5-47. PMID: 1555494.
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  122. Hale VG, Benet LZ. The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity. Pharmacology. 1992; 44(5):273-82. PMID: 1620723.
    View in: PubMed

  123. Volland C, Sun H, Dammeyer J, Benet LZ. Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein. Drug Metab Dispos. 1991 Nov-Dec; 19(6):1080-6. PMID: 1687014.
    View in: PubMed

  124. Hale VG, Aizawa K, Sheiner LB, Benet LZ. Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes. J Pharmacokinet Biopharm. 1991 Oct; 19(5):597-614. PMID: 1783993.
    View in: PubMed

  125. Kikkoji T, Gumbleton M, Higo N, Guy RH, Benet LZ. Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro. Pharm Res. 1991 Oct; 8(10):1231-7. PMID: 1796039.
    View in: PubMed

  126. Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats. Drug Metab Dispos. 1991 Sep-Oct; 19(5):853-7. PMID: 1686227.
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  127. Hammarlund-Udenaes M, Benet LZ. Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations. Biopharm Drug Dispos. 1991 Aug-Sep; 12(6):467-77. PMID: 1932610.
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  128. Nakashima E, Lau DT, Benet LZ. Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat. Pharm Res. 1991 Jul; 8(7):877-82. PMID: 1924138.
    View in: PubMed

  129. Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ. Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations. Pharm Res. 1991 Jun; 8(6):744-9. PMID: 1905809.
    View in: PubMed

  130. Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET. Stereoselective disposition of ketoprofen in rats. Drug Metab Dispos. 1991 May-Jun; 19(3):717-8. PMID: 1680643.
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  131. Benet LZ. Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist. DICP. 1991 Apr; 25(4):427-30. PMID: 1926916.
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  132. Lau DT, Gumbleton M, Labisch C, Benet LZ. Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat. Biopharm Drug Dispos. 1991 Apr; 12(3):215-22. PMID: 1905575.
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  133. Gumbleton M, Benet LZ. Drug metabolism and laboratory anesthetic protocols in the rat: examination of antipyrine pharmacokinetics. Pharm Res. 1991 Apr; 8(4):544-6. PMID: 1871056.
    View in: PubMed

  134. Gumbleton M, Benet LZ. Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers. Br J Clin Pharmacol. 1991 Feb; 31(2):211-3. PMID: 1904752; PMCID: PMC1368399.
    View in: PubMed, PubMed Central

  135. Hale VG, Benet LZ. Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver. Drug Metab Dispos. 1991 Jan-Feb; 19(1):87-93. PMID: 1673428.
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  136. Benet LZ. Safety and pharmacokinetics: colloidal bismuth subcitrate. Scand J Gastroenterol Suppl. 1991; 185:29-35. PMID: 1957122.
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  137. Volland C, Benet LZ. In vitro enantioselective glucuronidation of fenoprofen. Pharmacology. 1991; 43(2):53-60. PMID: 1775510.
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1981–1990

  1. Volland C, Sun H, Benet LZ. Stereoselective analysis of fenoprofen and its metabolites. J Chromatogr. 1990 Dec 14; 534:127-38. PMID: 2094699.
    View in: PubMed

  2. Lee FW, Salmonson T, Metzler CH, Benet LZ. Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs. J Pharmacol Exp Ther. 1990 Dec; 255(3):1222-9. PMID: 2124621.
    View in: PubMed

  3. Skelley JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A. Report of the workshop on in vitro and in vivo testing and correlation for oral controlled/modified-release dosage forms. J Pharm Sci. 1990 Sep; 79(9):849-54. PMID: 1980308.
    View in: PubMed

  4. Smith PC, Benet LZ, McDonagh AF. Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism. Drug Metab Dispos. 1990 Sep-Oct; 18(5):639-44. PMID: 1981713.
    View in: PubMed

  5. Manfro RC, Pohanka E, Tomlanovich SJ, Benet LZ, Salvatierra O, Garovoy MR. Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up. Transplant Proc. 1990 Aug; 22(4):1861-2. PMID: 2389461.
    View in: PubMed

  6. Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. J Clin Pharmacol. 1990 Jul; 30(7):643-53. PMID: 2391396.
    View in: PubMed

  7. Lau DT, Benet LZ. Nitroglycerin metabolism in subcellular fractions of rabbit liver. Dose dependency of glyceryl dinitrate formation and possible involvement of multiple isozymes of glutathione S-transferases. Drug Metab Dispos. 1990 May-Jun; 18(3):292-7. PMID: 1974188.
    View in: PubMed

  8. Nakashima E, Rigod JF, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses. Clin Pharmacol Ther. 1990 May; 47(5):592-8. PMID: 2111749.
    View in: PubMed

  9. Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ. Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene. Biopharm Drug Dispos. 1990 Apr; 11(3):233-43. PMID: 2328310.
    View in: PubMed

  10. Iwakawa S, Spahn H, Benet LZ, Lin ET. Stereoselective binding of the glucuronide conjugates of carprofen enantiomers to human serum albumin. Biochem Pharmacol. 1990 Mar 1; 39(5):949-53. PMID: 2310420.
    View in: PubMed

  11. Hamamoto K, Iwamoto HS, Roman CM, Benet LZ, Rudolph AM. Fetal uptake of intraamniotic digoxin in sheep. Pediatr Res. 1990 Mar; 27(3):282-5. PMID: 2320396.
    View in: PubMed

  12. Smith PC, McDonagh AF, Benet LZ. Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig. J Pharmacol Exp Ther. 1990 Jan; 252(1):218-24. PMID: 2299592.
    View in: PubMed

  13. Gupta SK, Benet LZ. High-fat meals increase the clearance of cyclosporine. Pharm Res. 1990 Jan; 7(1):46-8. PMID: 2300535.
    View in: PubMed

  14. Steffe EM, King JH, Inciardi JF, Flynn NF, Goldstein E, Tonjes TS, Benet LZ. The effect of acetaminophen on zidovudine metabolism in HIV-infected patients. J Acquir Immune Defic Syndr. 1990; 3(7):691-4. PMID: 2352121.
    View in: PubMed

  15. Wang LH, Rudolph AM, Benet LZ. Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods. Dev Pharmacol Ther. 1990; 14(3):161-79. PMID: 2364855.
    View in: PubMed

  16. Munafo A, McDonagh AF, Smith PC, Benet LZ. Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro. Pharm Res. 1990 Jan; 7(1):21-7. PMID: 2300531.
    View in: PubMed

  17. Nakashima E, Benet LZ. An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment. J Pharmacokinet Biopharm. 1989 Dec; 17(6):673-86. PMID: 2635739.
    View in: PubMed

  18. Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ. Pharmacokinetics of nicotinic acid-salicylic acid interaction. Clin Pharmacol Ther. 1989 Dec; 46(6):642-7. PMID: 2598568.
    View in: PubMed

  19. Gupta SK, Benet LZ. Absorption kinetics of cyclosporine in healthy volunteers. Biopharm Drug Dispos. 1989 Nov-Dec; 10(6):591-6. PMID: 2611359.
    View in: PubMed

  20. Watari N, Benet LZ. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. J Pharmacokinet Biopharm. 1989 Oct; 17(5):593-9. PMID: 2614687.
    View in: PubMed

  21. Teng RL, Benet LZ. Simultaneous measurement of prednisone, prednisolone and 6 beta-hydroxyprednisolone in urine by high-performance liquid chromatography using dexamethasone as the internal standard. J Chromatogr. 1989 Sep 1; 493(2):421-3. PMID: 2584309.
    View in: PubMed

  22. Iwakawa S, Suganuma T, Lee SF, Spahn H, Benet LZ, Lin ET. Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man. Drug Metab Dispos. 1989 Jul-Aug; 17(4):414-9. PMID: 2571482.
    View in: PubMed

  23. Bois FY, Tozer TN, Benet LZ, Zeise L. Lead exposure in children vs adults. Am J Public Health. 1989 Jul; 79(7):904. PMID: 2735489; PMCID: PMC1349686.
    View in: PubMed, PubMed Central

  24. Bois FY, Tozer TN, Zeise L, Benet LZ. Application of clearance concepts to the assessment of exposure to lead in drinking water. Am J Public Health. 1989 Jul; 79(7):827-31. PMID: 2735466; PMCID: PMC1349658.
    View in: PubMed, PubMed Central

  25. Koshida R, Nakashima E, Taniguchi N, Tsuji A, Benet LZ, Ichimura F. Prediction of the distribution volumes of cefazolin and tobramycin in obese children based on physiological pharmacokinetic concepts. Pharm Res. 1989 Jun; 6(6):486-91. PMID: 2762224.
    View in: PubMed

  26. Spahn H, Spahn I, Benet LZ. Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study. Clin Pharmacol Ther. 1989 May; 45(5):500-5. PMID: 2721105.
    View in: PubMed

  27. Gloff CA, Benet LZ. Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats. J Pharmacokinet Biopharm. 1989 Apr; 17(2):169-77. PMID: 2795454.
    View in: PubMed

  28. Hammarlund-Udenaes M, Benet LZ. Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update. J Pharmacokinet Biopharm. 1989 Feb; 17(1):1-46. PMID: 2654356.
    View in: PubMed

  29. Lau DT, Benet LZ. Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver. Biochem Pharmacol. 1989 Feb 1; 38(3):543-6. PMID: 2492808.
    View in: PubMed

  30. Manfro RC, Pohanka E, Tomlanovich S, Benet LZ, Garovoy MR. Cyclosporin A and prednisolone: an additive inhibitory effect of cell proliferation and interleukin-2 production. Transplant Proc. 1989 Feb; 21(1 Pt 2):1457-9. PMID: 2523586.
    View in: PubMed

  31. Spahn H, Iwakawa S, Lin ET, Benet LZ. Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides. Pharm Res. 1989 Feb; 6(2):125-32. PMID: 2762212.
    View in: PubMed

  32. Spahn H, Spahn I, Pflugmann G, Mutschler E, Benet LZ. Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component. J Chromatogr. 1988 Dec 9; 433:331-8. PMID: 3235564.
    View in: PubMed

  33. Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH. Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing. Biopharm Drug Dispos. 1988 Nov-Dec; 9(6):557-65. PMID: 3147725.
    View in: PubMed

  34. Nakashima E, Benet LZ. General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment. J Pharmacokinet Biopharm. 1988 Oct; 16(5):475-92. PMID: 3199315.
    View in: PubMed

  35. Gawienowski M, Benet LZ, Fleckenstein L, Lin ET. Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite. J Chromatogr. 1988 Sep 9; 430(2):412-9. PMID: 3235515.
    View in: PubMed

  36. Hyneck ML, Smith PC, Munafo A, McDonagh AF, Benet LZ. Disposition and irreversible plasma protein binding of tolmetin in humans. Clin Pharmacol Ther. 1988 Jul; 44(1):107-14. PMID: 3390998.
    View in: PubMed

  37. Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1988 Jun; 43(6):673-80. PMID: 3378388.
    View in: PubMed

  38. Lee FW, Watari N, Rigod J, Benet LZ. Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection. J Chromatogr. 1988 Apr 29; 426(2):259-66. PMID: 3134385.
    View in: PubMed

  39. Hyneck ML, Munafo A, Benet LZ. Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide. Drug Metab Dispos. 1988 Mar-Apr; 16(2):322-4. PMID: 2898354.
    View in: PubMed

  40. Gloff CA, Mamelok RD, Benet LZ. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 1988; 37(4):268-76. PMID: 3194444.
    View in: PubMed

  41. Hyneck ML, Smith PC, Unseld E, Benet LZ. High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine. J Chromatogr. 1987 Sep 25; 420(2):349-56. PMID: 3693506.
    View in: PubMed

  42. Noonan PK, Benet LZ. Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration. Clin Pharmacol Ther. 1987 Sep; 42(3):273-7. PMID: 3113806.
    View in: PubMed

  43. Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharm Res. 1987 Aug; 4(4):348-52. PMID: 3508542.
    View in: PubMed

  44. Nakashima E, Noonan PK, Benet LZ. Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin. J Pharmacokinet Biopharm. 1987 Aug; 15(4):423-37. PMID: 3119815.
    View in: PubMed

  45. Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N. Pharmacokinetics and excretion of unique beta-adrenergic agonists. Pharmacology. 1987; 34(2-3):157-66. PMID: 2884679.
    View in: PubMed

  46. Wang LH, Zakim D, Rudolph AM, Benet LZ. Developmental alterations in hepatic UDP-glucuronosyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs. Biochem Pharmacol. 1986 Sep 15; 35(18):3065-70. PMID: 3092831.
    View in: PubMed

  47. Benet LZ. AAPS and pharmaceutical research. Pharm Res. 1986 Aug; 3(4):186. PMID: 24271580.
    View in: PubMed

  48. Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ. Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function. Clin Pharmacol Ther. 1986 Aug; 40(2):226-32. PMID: 3731685.
    View in: PubMed

  49. Wang LH, Rudolph AM, Benet LZ. Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit. J Pharmacol Exp Ther. 1986 Jul; 238(1):198-205. PMID: 3723398.
    View in: PubMed

  50. Smith PC, Benet LZ. Characterization of the isomeric esters of zomepirac glucuronide by proton NMR. Drug Metab Dispos. 1986 Jul-Aug; 14(4):503-5. PMID: 2874000.
    View in: PubMed

  51. Varughese A, Brater DC, Benet LZ, Lee CS. Ethambutol kinetics in patients with impaired renal function. Am Rev Respir Dis. 1986 Jul; 134(1):34-8. PMID: 3729159.
    View in: PubMed

  52. Shi RJ, Benet LZ, Lin ET. High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride. J Chromatogr. 1986 Apr 25; 377:399-404. PMID: 3711234.
    View in: PubMed

  53. Legler UF, Benet LZ. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives. Clin Pharmacol Ther. 1986 Apr; 39(4):425-9. PMID: 3956058.
    View in: PubMed

  54. Noonan PK, Benet LZ. The bioavailability of oral nitroglycerin. J Pharm Sci. 1986 Mar; 75(3):241-3. PMID: 3084757.
    View in: PubMed

  55. Smith PC, McDonagh AF, Benet LZ. Irreversible binding of zomepirac to plasma protein in vitro and in vivo. J Clin Invest. 1986 Mar; 77(3):934-9. PMID: 3949982; PMCID: PMC423485.
    View in: PubMed, PubMed Central

  56. Sörgel F, Ettinger B, Benet LZ. Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis. J Pharm Sci. 1986 Feb; 75(2):129-32. PMID: 3958920.
    View in: PubMed

  57. Legler UF, Benet LZ. The effect of prednisone and hydrocortisone on the plasma protein binding of prednisolone in man. Eur J Clin Pharmacol. 1986; 30(1):51-5. PMID: 3709632.
    View in: PubMed

  58. Gustavson LE, Legler UF, Benet LZ. Impairment of prednisolone disposition in women taking oral contraceptives or conjugated estrogens. J Clin Endocrinol Metab. 1986 Jan; 62(1):234-7. PMID: 2999180.
    View in: PubMed

  59. Gustavson LE, Benet LZ. The macromolecular binding of prednisone in plasma of healthy volunteers including pregnant women and oral contraceptive users. J Pharmacokinet Biopharm. 1985 Dec; 13(6):561-9. PMID: 3834071.
    View in: PubMed

  60. Wang LH, Rudolph AM, Benet LZ. Distribution and fate of acetaminophen conjugates in fetal lambs in utero. J Pharmacol Exp Ther. 1985 Nov; 235(2):302-7. PMID: 4057072.
    View in: PubMed

  61. Sheiner LB, Benet LZ. Premarketing observational studies of population pharmacokinetics of new drugs. Clin Pharmacol Ther. 1985 Nov; 38(5):481-7. PMID: 3931953.
    View in: PubMed

  62. Benet LZ. Mean residence time in the body versus mean residence time in the central compartment. J Pharmacokinet Biopharm. 1985 Oct; 13(5):555-8. PMID: 3834069.
    View in: PubMed

  63. Smith PC, Langendijk PN, Bosso JA, Benet LZ. Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac. Clin Pharmacol Ther. 1985 Aug; 38(2):121-7. PMID: 3874742.
    View in: PubMed

  64. Ferraiolo BL, Benet LZ. Peptides and proteins as drugs. Pharm Res. 1985 Jul; 2(4):151-6. PMID: 24272804.
    View in: PubMed

  65. Noonan PK, Williams RL, Benet LZ. Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers. J Pharmacokinet Biopharm. 1985 Apr; 13(2):143-57. PMID: 3932639.
    View in: PubMed

  66. Benet LZ. Pharmacokinetics and metabolism of bepridil. Am J Cardiol. 1985 Mar 15; 55(7):8C-13C. PMID: 3872057.
    View in: PubMed

  67. Tsang SY, Garovoy MR, Benet LZ. Immunosuppressive activity of prednisone and prednisolone and their metabolic interconversion in the mixed lymphocyte reaction. Int J Immunopharmacol. 1985; 7(5):731-7. PMID: 2931388.
    View in: PubMed

  68. Noonan PK, Benet LZ. Incomplete and delayed bioavailability of sublingual nitroglycerin. Am J Cardiol. 1985 Jan 1; 55(1):184-7. PMID: 3917598.
    View in: PubMed

  69. Smith PC, Hasegawa J, Langendijk PN, Benet LZ. Stability of acyl glucuronides in blood, plasma, and urine: studies with zomepirac. Drug Metab Dispos. 1985 Jan-Feb; 13(1):110-2. PMID: 2858367.
    View in: PubMed

  70. Wang LH, Rudolph AM, Benet LZ. Pharmacokinetics of drugs and metabolites in the maternal-placental-fetal unit: general principles. NIDA Res Monogr. 1985; 60:25-38. PMID: 3932864.
    View in: PubMed

  71. Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. J Pharmacokinet Biopharm. 1984 Dec; 12(6):575-86. PMID: 6533293.
    View in: PubMed

  72. Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. Am J Med. 1984 Nov 5; 77(5A):59-61. PMID: 6496560.
    View in: PubMed

  73. Noonan PK, Kanfer I, Riegelman S, Benet LZ. Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection. J Pharm Sci. 1984 Jul; 73(7):923-7. PMID: 6432997.
    View in: PubMed

  74. Sörgel F, Lin ET, Hasegawa J, Benet LZ. Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine. J Pharm Sci. 1984 Jun; 73(6):831-3. PMID: 6737274.
    View in: PubMed

  75. Langendijk PN, Smith PC, Hasegawa J, Benet LZ. Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. J Chromatogr. 1984 May 11; 307(2):371-9. PMID: 6610684.
    View in: PubMed

  76. Smith PC, Benet LZ. High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine. J Chromatogr. 1984 Mar 9; 306:315-21. PMID: 6715469.
    View in: PubMed

  77. Meister W, Benowitz NL, Benet LZ. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology. 1984; 28(2):90-4. PMID: 6709691.
    View in: PubMed

  78. Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies. Pharmacology. 1984; 28(4):181-7. PMID: 6728896.
    View in: PubMed

  79. Benet LZ. Pharmacokinetic parameters: which are necessary to define a drug substance? Eur J Respir Dis Suppl. 1984; 134:45-61. PMID: 6586486.
    View in: PubMed

  80. Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J. Oral bioavailability and intravenous pharmacokinetics of amrinone in humans. J Pharm Sci. 1983 Jul; 72(7):817-9. PMID: 6886991.
    View in: PubMed

  81. Baughman RA, Sorgel F, Mico BA, Benet LZ. Dose-dependent bioavailability of prazosin in beagle dogs. J Cardiovasc Pharmacol. 1983 Jul-Aug; 5(4):613-7. PMID: 6193359.
    View in: PubMed

  82. Lozada F, Frey FJ, Benet LZ. Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases. J Dent Res. 1983 May; 62(5):575-7. PMID: 6573375.
    View in: PubMed

  83. Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG. Furosemide assays and disposition in healthy volunteers and renal transplant patients. Fed Proc. 1983 Apr; 42(6):1695-8. PMID: 6339277.
    View in: PubMed

  84. Baughman RA, Mico BA, Benet LZ. The bioavailability and disposition of tiodazosin levulinate in beagle dogs with a comparison to prazosin hydrochloride. Drug Metab Dispos. 1983 Mar-Apr; 11(2):143-6. PMID: 6133719.
    View in: PubMed

  85. Smith DE, Benet LZ. Biotransformation of furosemide in kidney transplant patients. Eur J Clin Pharmacol. 1983; 24(6):787-90. PMID: 6350024.
    View in: PubMed

  86. Smith DE, Benet LZ. Plasma protein binding of furosemide in kidney transplant patients. J Pharmacokinet Biopharm. 1982 Dec; 10(6):663-74. PMID: 6763626.
    View in: PubMed

  87. Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM. Endogenous and exogenous glucocorticoids in cushingoid patients. Drug Intell Clin Pharm. 1982 Nov; 16(11):863-8. PMID: 6756849.
    View in: PubMed

  88. Legler UF, Frey FJ, Benet LZ. Prednisolone clearance at steady state in man. J Clin Endocrinol Metab. 1982 Oct; 55(4):762-7. PMID: 7107818.
    View in: PubMed

  89. O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ. Disposition of zomepirac sodium in man. J Clin Pharmacol. 1982 Oct; 22(10):470-6. PMID: 7174855.
    View in: PubMed

  90. Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ. Pharmacokinetics of triamterene and its metabolite in man. J Pharmacokinet Biopharm. 1982 Oct; 10(5):507-23. PMID: 7166735.
    View in: PubMed

  91. Hasegawa J, Smith PC, Benet LZ. Apparent intramolecular acyl migration of zomepirac glucuronide. Drug Metab Dispos. 1982 Sep-Oct; 10(5):469-73. PMID: 6128195.
    View in: PubMed

  92. Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ. Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography. J Chromatogr. 1982 Jul 9; 230(2):454-60. PMID: 6213630.
    View in: PubMed

  93. Mico BA, Baughman RA, Benet LZ. Determination of tiodazosin in plasma and whole blood by high-performance liquid chromatography. J Chromatogr. 1982 Jun 11; 230(1):203-6. PMID: 7107763.
    View in: PubMed

  94. Frey BM, Frey FJ, Holford NH, Lozada F, Benet LZ. Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction. Transplantation. 1982 Jun; 33(6):578-84. PMID: 6213074.
    View in: PubMed

  95. Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. J Pharm Sci. 1982 May; 71(5):533-5. PMID: 7097499.
    View in: PubMed

  96. Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ. Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. Eur J Clin Pharmacol. 1982; 23(1):65-74. PMID: 6751835.
    View in: PubMed

  97. Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. J Clin Pharmacol. 1982 Jan; 22(1):32-41. PMID: 7061724.
    View in: PubMed

  98. Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. J Clin Pharmacol. 1981 Nov-Dec; 21(11-12 Pt 1):493-500. PMID: 7037867.
    View in: PubMed

  99. Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ. Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone. J Clin Endocrinol Metab. 1981 Nov; 53(5):1076-80. PMID: 7026594.
    View in: PubMed

  100. Mamelok RD, Macrae DR, Benet LZ, Prusiner SB. Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica. J Neurochem. 1981 Sep; 37(3):768-74. PMID: 6115891.
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  101. Gustafson JH, Benet LZ. Saturable kinetics of intravenous chlorothiazide in the rhesus monkey. J Pharmacokinet Biopharm. 1981 Aug; 9(4):461-76. PMID: 7310644.
    View in: PubMed

  102. Smith DE, Gambertoglio JG, Vincenti F, Benet LZ. Furosemide kinetics and dynamics after kidney transplant. Clin Pharmacol Ther. 1981 Jul; 30(1):105-13. PMID: 7016396.
    View in: PubMed

  103. Sheiner LB, Benet LZ, Pagliaro LA. A standard approach to compiling clinical pharmacokinetic data. J Pharmacokinet Biopharm. 1981 Feb; 9(1):59-127. PMID: 7014827.
    View in: PubMed

  104. Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys-intravenous bolus studies. Pharmacology. 1981; 23(6):326-36. PMID: 7312942.
    View in: PubMed

  105. Frey FJ, Amend WJ, Lozada F, Frey BM, Holford NH, Benet LZ. Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients. Eur J Clin Pharmacol. 1981; 21(3):235-42. PMID: 7032949.
    View in: PubMed

1971–1980

  1. Frey BM, Frey FJ, Cochrum KC, Benet LZ. Induction kinetics of human suppressor cells in the mixed lymphocyte reaction and influence of prednisolone on their genesis. Cell Immunol. 1980 Nov; 56(1):225-34. PMID: 6448699.
    View in: PubMed

  2. Frey FJ, Frey BM, Greither A, Benet LZ. Prednisolone clearance at steady state in dogs. J Pharmacol Exp Ther. 1980 Nov; 215(2):287-91. PMID: 7441495.
    View in: PubMed

  3. Brater DC, Kaojarern S, Benet LZ, Lin ET, Lockwood T, Morris RC, McSherry EJ, Melmon KL. Renal excretion of pseudoephedrine. Clin Pharmacol Ther. 1980 Nov; 28(5):690-4. PMID: 7438686.
    View in: PubMed

  4. Lin ET, Baughman RA, Benet LZ. High-performance liquid chromatographic determination of prazosin in human plasma, whole blood and urine. J Chromatogr. 1980 Sep 12; 183(3):367-71. PMID: 7419656.
    View in: PubMed

  5. Smith DE, Lin ET, Benet LZ. Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay. Drug Metab Dispos. 1980 Sep-Oct; 8(5):337-42. PMID: 6107232.
    View in: PubMed

  6. Lee CS, Brater DC, Gambertoglio JG, Benet LZ. Disposition kinetics of ethambutol in man. J Pharmacokinet Biopharm. 1980 Aug; 8(4):335-46. PMID: 7431225.
    View in: PubMed

  7. Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL. Altered prazosin pharmacokinetics in congestive heart failure. Eur J Clin Pharmacol. 1980 Jun; 17(6):425-8. PMID: 7398734.
    View in: PubMed

  8. Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ. Preliminary evaluation of furosemide-probenecid interaction in humans. J Pharm Sci. 1980 May; 69(5):571-5. PMID: 7381747.
    View in: PubMed

  9. Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH. Inhibition by indomethacin of the glycemic response to arginine in man. Proc Soc Exp Biol Med. 1980 Feb; 163(2):237-9. PMID: 6987677.
    View in: PubMed

  10. Lee CS, Marbury TC, Benet LZ. Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol. J Pharmacokinet Biopharm. 1980 Feb; 8(1):69-81. PMID: 7381692.
    View in: PubMed

  11. Gambertoglio JG, Amend WJ, Benet LZ. Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review. J Pharmacokinet Biopharm. 1980 Feb; 8(1):1-52. PMID: 6991663.
    View in: PubMed

  12. Williams RL, Benet LZ. Drug pharmacokinetics in cardiac and hepatic disease. Annu Rev Pharmacol Toxicol. 1980; 20:389-413. PMID: 6992701.
    View in: PubMed

  13. Till AE, Benet LZ. Renal excretion of pseudoephedrine in the rat. J Pharmacol Exp Ther. 1979 Dec; 211(3):555-60. PMID: 41938.
    View in: PubMed

  14. Ding TL, Benet LZ. Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug Metab Dispos. 1979 Nov-Dec; 7(6):373-7. PMID: 43222.
    View in: PubMed

  15. Frey FJ, Frey BM, Benet LZ. Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma. Clin Chem. 1979 Nov; 25(11):1944-7. PMID: 498504.
    View in: PubMed

  16. Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ. Cefamandole kinetics in uremic patients undergoing hemodialysis. Clin Pharmacol Ther. 1979 Nov; 26(5):592-9. PMID: 498702.
    View in: PubMed

  17. Arnold SB, Williams RL, Ports TA, Baughman RA, Benet LZ, Parmley WW, Chatterjee K. Attenuation of prazosin effect on cardiac output in chronic heart failure. Ann Intern Med. 1979 Sep; 91(3):345-9. PMID: 475164.
    View in: PubMed

  18. Benet LZ, Galeazzi RL. Noncompartmental determination of the steady-state volume of distribution. J Pharm Sci. 1979 Aug; 68(8):1071-4. PMID: 480170.
    View in: PubMed

  19. Lin ET, Smith DE, Benet LZ, Hoener BA. High-performance liquid chromatographic assays for furosemide in plasma and urine. J Chromatogr. 1979 Jul 21; 163(3):315-21. PMID: 541387.
    View in: PubMed

  20. Ding TL, Benet LZ. Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography. J Chromatogr. 1979 Jul 21; 163(3):281-8. PMID: 120373.
    View in: PubMed

  21. Smith DE, Brater DC, Lin ET, Benet LZ. Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation. J Pharmacokinet Biopharm. 1979 Jun; 7(3):265-74. PMID: 480148.
    View in: PubMed

  22. Benet LZ. Pharmacokinetics/pharmacodynamics of furosemide in man: a review. J Pharmacokinet Biopharm. 1979 Feb; 7(1):1-27. PMID: 458552.
    View in: PubMed

  23. Till AE, Benet LZ. Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique. Pharmacology. 1979; 18(6):306-10. PMID: 493335.
    View in: PubMed

  24. Smith DE, Benet LZ. Relationship between urinary excretion rate, steady-state plasma levels and diuretic response of furosemide in the rat. Pharmacology. 1979; 19(6):301-6. PMID: 549032.
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  25. Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K. Pharmacokinetics of furosemide in patients with congestive heart failure. Pharmacology. 1979; 19(3):121-31. PMID: 523503.
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  26. Benet LZ. Effect of route of administration and distribution on drug action. J Pharmacokinet Biopharm. 1978 Dec; 6(6):559-85. PMID: 731418.
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  27. Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. Anesthesiology. 1978 Nov; 49(5):324-9. PMID: 736287.
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  28. Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. J Pharmacokinet Biopharm. 1978 Apr; 6(2):153-64. PMID: 671221.
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  29. Lee CS, Benet LZ. Micro and macro GLC determination of ethambutol in biological fluids. J Pharm Sci. 1978 Apr; 67(4):470-3. PMID: 641750.
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  30. Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ. Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):136-42. PMID: 624775.
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  31. Barnett G, Lockwood T, Arancibia A, Benet LZ. Ascorbate stimulation of salicylate absorption in isolated rat intestine. J Pharm Sci. 1978 Feb; 67(2):224-6. PMID: 621642.
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  32. García CR, Siqueiros A, Benet LZ. Oral controlled release preparations. Pharm Acta Helv. 1978; 53(3-4):99-109. PMID: 360228.
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  33. Ding TL, Lin ET, Benet LZ. The reversible biotransformation of N-acetylprocainamide in the rhesus monkey. Arzneimittelforschung. 1978; 28(2):281-3. PMID: 416831.
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  34. Peck CC, Benet LZ. General method for determining macrodissociation constants of polyprotic, amphoteric compounds from solubility measurements. J Pharm Sci. 1978 Jan; 67(1):12-6. PMID: 22738.
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  35. Lee CS, Gambertoglio JG, Brater DC, Benet LZ. Kinetics of oral ethambutol in the normal subject. Clin Pharmacol Ther. 1977 Nov; 22(5 Pt 1):615-21. PMID: 410579.
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  36. Lin ET, Brater DC, Benet LZ. Gas-liquid chromatographic determination of pseudoephedrine and norpseudoephedrine in human plasma and urine. J Chromatogr. 1977 Oct 21; 140(3):275-9. PMID: 914918.
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  37. Miller RD, Matteo RS, Benet LZ, Sohn YJ. The pharmacokinetics of d-tubocurarine in man with and without renal failure. J Pharmacol Exp Ther. 1977 Jul; 202(1):1-7. PMID: 195035.
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  38. Ronfeld RA, Benet LZ. Interpretation of plasma concentration-time curves after oral dosing. J Pharm Sci. 1977 Feb; 66(2):178-80. PMID: 839412.
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  39. Lee CS, Benet LZ. Gas-liquid chromatographic determination of ethambutol in plasma and urine of man and monkey. J Chromatogr. 1976 Nov 17; 128(1):188-92. PMID: 825525.
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  40. Galeazzi RL, Benet LZ, Sheiner LB. Relationship between the pharmacokinetics and pharmacodynamics of procainamide. Clin Pharmacol Ther. 1976 Sep; 20(3):278-89. PMID: 954350.
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  41. Galeazzi RL, Benet LZ. Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems. J Pharmacokinet Biopharm. 1976 Feb; 4(1):43-56. PMID: 1271239.
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  42. Gustafson JH, Schoenwald RD, Benet LZ. Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities. J Pharm Sci. 1976 Feb; 65(2):243-7. PMID: 1255456.
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  43. Galeazzi RL, Sheiner LB, Lockwood T, Benet LZ. The renal elimination of procainamide. Clin Pharmacol Ther. 1976 Jan; 19(1):55-62. PMID: 1171.
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  44. Pagliaro LA, Benet LZ. Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references. J Pharmacokinet Biopharm. 1975 Oct; 3(5):333-83. PMID: 1107513.
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  45. Orr JM, Benet LZ. The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies. Am J Dig Dis. 1975 Sep; 20(9):858-65. PMID: 1163521.
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  46. Till AE, Benet LZ, Kwan KC. An integrated approach to the pharmacokinetic analysis of drug absorption. J Pharmacokinet Biopharm. 1974 Dec; 2(6):525-44. PMID: 4461782.
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  47. Gustafson JH, Benet LZ. Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. J Pharm Pharmacol. 1974 Dec; 26(12):937-44. PMID: 4156858.
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  48. Nayak RK, Benet LZ. Use of the unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs. J Pharmacokinet Biopharm. 1974 Oct; 2(5):417-31. PMID: 4452944.
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  49. Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm. 1973 Apr; 1(2):123-36. PMID: 4764426.
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  50. Wolfe DL, Forland SC, Benet LZ. Drug transfer across intact rat intestinal mucosa following surgical removal of serosa and muscularis externa. J Pharm Sci. 1973 Feb; 62(2):200-5. PMID: 4686389.
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  51. Nelson JA, Moss AA, Goldberg HI, Benet LZ, Amberg J. Gastrointestinal absorption of iopanoic acid. Invest Radiol. 1973 Jan-Feb; 8(1):1-8. PMID: 4685376.
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  52. Benet LZ. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. J Pharm Sci. 1972 Apr; 61(4):536-41. PMID: 5014309.
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  53. Benet LZ, Turi JS. Use of general partial fraction theorem for obtaining inverse laplace transforms in pharmacokinetic analysis. J Pharm Sci. 1971 Oct; 60(10):1593-4. PMID: 5129385.
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  54. Nayak RK, Benet LZ. Drug transfer across rat intestinal musculature after edetic acid treatment. J Pharm Sci. 1971 Oct; 60(10):1508-11. PMID: 5001965.
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  55. Benet LZ, Orr JM, Turner RH, Webb HS. Effect of buffer constituents and time on drug transfer across in vitro rat intestine. J Pharm Sci. 1971 Feb; 60(2):234-8. PMID: 5572446.
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1965–1970

  1. Turner RH, Mehta CS, Benet LZ. Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies. J Pharm Sci. 1970 May; 59(5):590-5. PMID: 5446410.
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  2. Rowland M, Benet LZ, Riegelman S. Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics. J Pharm Sci. 1970 Mar; 59(3):364-7. PMID: 5416180.
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  3. Benet LZ, Ronfeld RA. Volume terms in pharmacokinetics. J Pharm Sci. 1969 May; 58(5):639-41. PMID: 5796463.
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  4. Benet LZ, Goyan JE. Potentiometric determination of dissociation constants. J Pharm Sci. 1967 Jun; 56(6):665-80. PMID: 5340617.
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  5. Benet LZ, Goyan JE. Thermodynamics of chelation by tetracyclines. J Pharm Sci. 1966 Nov; 55(11):1184-90. PMID: 4961420.
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  6. Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN. Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. J Pharm Sci. 1966 Jan; 55(1):63-8. PMID: 5918653.
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  7. Benet LZ, Goyan JE. Nonlogarithmic titration curves for the determination of dissociation constants and purity. J Pharm Sci. 1965 Aug; 54(8):1179-82. PMID: 4956613.
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  8. Benet LZ, Goyan JE. Determination of the stability constants of tetracycline complexes. J Pharm Sci. 1965 Jul; 54(7):983-7. PMID: 5862536.
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