Areas of Focus

In order to make personalized medicine accessible, we must first understand its use and impact on clinical care, health economics, and health policy. TRANSPERS is at the leading edge of these fields, applying multidisciplinary approaches to collect and study real-world examples that can guide the future use of personalized medicine to improve health and healthcare. Our current research focuses on:

Real-world Evidence

Understanding how personalized medicine unfolds in the real world requires gathering real-world evidence. TRANSPERS is working with clinics and health plans to gather data that we can use to examine questions about utilization and costs of personalized medicine. Our ongoing work harnesses real-world evidence around several important technologies in personalized medicine for cancer and other major diseases.

Decision-making

How do key stakeholders make decisions about different types of personalized treatments? TRANSPERS is leading several research projects that address how patients, providers and healthcare payers make decisions. These studies range from qualitative interviews and focus groups to quantitative, population-based surveys. We focus on diverse populations, including oncology patients, family members of high-risk patients, and health care payers.

Value

Medical technologies have the potential to improve human health, but we also need to consider their value relative to their cost and how to reduce waste and inefficiency TRANSPERS brings together leaders from a wide array of fields, including economics, policy and clinical medicine, to apply methods that can help define the value of personalized medicine. Examples of these methods include:

  • Stated preferences techniques
  • Cost-effectiveness and cost-utility analysis
  • Evidence synthesis and technology evaluation

These diverse perspectives and approaches allow us to consider translation from multiple angles and pursue truly interdisciplinary research to advance our knowledge of personalized medicine.

Policy Impact

Policy decisions require a robust evidence-base to guide and inform them. TRANSPERS is building frameworks to develop and analyze the evidence needed to accelerate the translation of personalized medicine into policies that improve health outcomes. We focus on clinical application, economics, and reimbursement, and apply real-world examples to highlight current challenges and potential solutions. We are developing a general framework to assess the economic value of personalized medicine, and we continue to refine a framework that can be useful for policy decisions such as in reimbursement and coverage decision-making.