Research laboratory of Xin Chen, PhD
Liver Cancer Research

Publications

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2017

  • Cigliano A, Wang C, Pilo MG, Szydlowska M, Brozzetti S, Latte G, Pes GM, Pascale RM, Seddaiu MA, Vidili G, Ribback S, Donbrowski F, Evert M, Chen X#, and Calvisi DF# (#Co-corresponding authors).
    Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice
    Oncotarget, Epub Apr. 2017| PubMed Link | Link to the Journal
  • Oliveira DV, Zhang S, Chen X, Calvisi DF and Andersen JB.
    Molecular profiling of intrahepatic cholangiocarcinoma: the search for new therapeutic targets
    Expert Rev Gastroenterol Hepatol,Vol. 11(4), Apr. 2017, pp349-356 | PubMed Link | Link to the Journal
  • Cigliano A, Wang J, Chen X,and Calvisi DF.
    Role of Notch signaling in cholangiocarcinoma.
    Expert Opin Ther Targets, Vol. 21(5), May. 2017, pp471-483 | PubMed Link | Link to the Journal
  • Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo M, Cialiano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Downbrowski F, Ta J, Calvisi DF, Chen L and Chen X.
    A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis.
    Hepatology Epub Mar. 2017 | PubMed Link | Link to the Journal
  • Che L, Pilo MG, Cigliano A, Latte G, Simile MM, Ribback S, Dombrowski F, Evert M, Chen X# ,and Calvisi F# (#Co-corresponding authors).
    Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.
    Cell Cycle, Epub Jan. 2017 | PubMed Link | Link to the Journal

2016

  • Wu H, Zhang T, Pan F, Steer CJ, Li Z, Chen X, and Song G.
    MicroRNA-206 prevents hepatosteatosis and hyperglycermia by facilitating insulin signaling and impairing lipogenesis
    Journal of Hepatology, Epub Dec. 2016 | PubMed Link | Link to the Journal
  • Tao J, Zhang R, Singh S, Poddar M, Xu E, Oertel M, Chen X, Ganesh S, Abrams M and Monga SP.
    Targeting β-catenin in hepatocellular cancers induced by co-expression of mutant β-catenin and K-Ras in mice​
    Hepatology Epub Dec. 2016 | PubMed Link | Link to the Journal
  • Chen X,and Calvisi DF
    The dark side of the moon: AKT as a tumor suppressor in the liver
    Hepatology, Vol. 64(4), Oct. 2016, pp1358-1361 | PubMed Link | Link to the Journal
  • Che L, Fan B, Pilo MG, Xu Z, Liu Y, Cigliano A, Cossu A, Palmieri G, Pascale RM, Porcu A, Vidili G, Serra M, Downbrowski F, Ribback S, Calvisi DF and Chen X.
    Jagged 1 is a major Notch ligand alone cholangiocarcinoma development in mice and humans​
    Oncogenesis, Vol. 5(12), Dec. 2016, e274 | PubMed Link | Link to the Journal
  • Tao J, Xu E, Zhao Y, Singh S, Li X, Couchy G, Chen X, Zucman-Rossi J, Chikina M, Monga SP
    Modeling a human HCC subset in mice through co-expression of MET and point-mutant β-catenin​
    Hepatology, Epub Apr. 2016 | PubMed Link | Link to the Journal
  • Cao D, Song X, Che L, Li X, Pilo MG, Vidili G, Porcu A, Solinas A, Cigliano A, Ribback S, Dombrowski F, Chen X, Li L and Calvisi DF
    Both de novo synthetized and exogenous fatty acid support the growth of hepatocellular carcinoma cells
    Liver International, Epub Jun. 2016 | PubMed Link | Link to the Journal
  • Hale G, Liu X, Hu J, Xu Z, Che L, Solomon D, Tsokos C, Shafizadeh N, Chen X, Gill R and Kakar S
    Correlation of β-catenin exon 3 mutations with Glutamine Synthetase patterns in hepatocellular carcinoma and hepatocellular adenoma​
    Modern Pathology, Epub Jul. 2016 | PubMed Link | Link to the Journal
  • Samarin J, Laketa V, Malz M, Roessler S, Stein I, Horwitz E, Singer S, Dimou E, Cigliano A, Falk CS, Chen X,Dooley S, Pikarsky E, Calvisi DF, Schultz C, Schirmacher P and Breuhahn K.
    PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells
    Hepatology, Vol. 63(3), Mar. 2016, pp813-826 | PubMed Link | Link to the Journal

  • Li L, Che L, Tharp KM, Park HM, Pilo MG, Can D, Cigliano A, Latte G, Xu Z, Ribback S, Dombrowski F, Evert M, Gores GJ, Stahl A, Calvisi DF and Chen X.
    Differential requirement of de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans
    Hepatology, Epub Feb. 2016 | PubMed Link | Link to the Journal

  • Hu J, Che L, Li L, Pilo GM, Cigliano A, Ribback S, Latte G, Mela M, Evert M, Dombrowski F, Zheng G, Chen X# and Calvisi DF# (#Co-corresponding authors).
    Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via mTORC1/FASN pathway in mice
    Scientific Reports, Epub Feb. 2016 | PubMed Link | Link to the Journal

  • Ding N, Che L, Li X, Liu Y, Jiang L, Fan B, Tao J, Chen X and Ji JF.
    Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice
    World Journal of Gastroenterology, Vol. 22(6), Feb. 2016, pp2071-2080 | PubMed Link | Link to the Journal

2015

  • Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, Demartis MI, Tao J, Gui B, Birnbaum MJ, Ribback S, Sattu S, Utpatel K, Dombrowski, F, Evert M, Calvisi DF and Chen X.
    Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumor formation in mice via AKT2/mTORC1 cascade
    Liver International, Epub Dec. 2015 | PubMed Link | Link to the Journal

  • Juric V, Ruffell B, Evason K, Che L, Hu J, Che L, Wang L, Chen X and Bishop JM.
    Monocyte-dependent liver injury promotes carcinogenesis in an oncogene-specific manner
    Journal of Hepatology, Epub Nov. 2015 | PubMed Link | Link to the Journal

  • Li L, Che L, Wang C, Murphy ST, Blecha JE, Li X, VanBrocklin HV, Calvisi, DF, Puchowicz M, Chen X# and Seo Y#. (#Co-corresponding authors)
    11C-Acetate PET imaging is not associated with fatty acid synthase expression or de novo lipogenesis in hepatocellular carcinoma in mice
    Molecular Imaging and Biology, Epub Nov. 2015| PubMed Link | Link to the Journal

  • Li L, Pilo GM, Li XL, Latte G, Cigliano A, Che L, Mela M, Joseph C, Wang C, Jiang L, Simile MM, Ribback S, Pascale RM, Dombrowski F, Evert M, Semenkovick CF, Chen X and Calvisi DF
    Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans
    Journal of Hepatology, Epub Oct. 2015| PubMed Link | Link to the Journal

  • Wu H, Ng R, Chen X, Steer CJ and Song G.
    MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
    Gut, Epub Aug. 2015| PubMed Link | Link to the Journal

  • Li X, Tao J, Cigliano A, Sini M, Calderaro J, Aoulay D, Wang C, Liu Y, Jiang L, Evert K, Demartis MI, Ribback S, Dombrowski F, Evert M, Calvisi DF and Chen X
    Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver
    Oncotarget, Epub Mar., 2015| PubMed Link | Link to the Journal

  • Tao J, Ji J, Li X, Ning D, Wu H, Liu Y, Wang XW, Calvisi DF, Song G, and Chen X
    Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver Cancer
    Oncotarget. 2015 Mar 30;6(9):6977-88.| PubMed Link | Link to the Journal

  • Yamada D, Rizvi S, Razumilava N, Bronk SF, Davila JI, Champion MD, Board MJ, Bezerra JA, Chen X, and Gores GJ
    IL-33 facilitates oncogene induced cholangiocarcinoma in mice by an IL-6 sensitive mechanism.
    Hepatology. 2015 May;61(5):1627-42. doi: 10.1002/hep.27687| PubMed Link | Link to the Journal

2014

  • Delogu S, Wang C, Cigliano A, Utpatel K, Sini M, Longerich T, Waldburger N, Breuhahn K, Jiang L, Dombrowski F, Evert M, Chen X# and Calvisi DF# (#Co-corresponding authors)
    SKP2 cooperates with N-Ras or AKT to induce liver tumor development in the mouse
    Oncotarget, Epub Dec., 2014| PubMed Link | Link to the Journal

  • Huntzicker EG, Hotzel K, Choy L, Che L, Ross J, Pau G, Sharma N, Siebel CW, Chen X and French DM
    Differential effects of targeting Notch receptors in a mouse model of liver cancer.
    Hepatology, Epub October, 2014| PubMed Link | Link to the Journal

  • Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo MG, Liu Y, Gui B, Sini M, Smith JW, Dombrowski F, Calvisi DF, Evert M, Chen X.
    4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras protooncogenes.
    Hepatology. 2015 Jan;61(1):200-13| PubMed Link | Link to the Journal

  • Tao JY, Calvisi DF, Ranganathan S, Cigliano A, Zhaou L, Singh S, Jiang L, Fan B, Terracciano L, Armeanu-Ebinger S, Ribback S, Dombrowski F, Evert M, Chen X#, and Monga SP# (#Co-corresponding authors).
    Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice
    Gastroenterology. 2014 May 14.| PubMed Link | Link to the Journal

  • Ng R, Wu H, Xiao H,Chen X, Willenbring H, Steer CJ and Song G.
    Inhibition of miR-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia.
    Hepatology. 2014 Mar 28. doi: 10.1002/hep.27153. [Epub ahead of print]| PubMed Link | Link to the Journal

  • Chen X, Calvisi DF.
    Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research.
    Am J Pathol. 2014 Apr;184(4):912-23.| PubMed Link | Link to the Journal

2013

  • Pellegrino R, Calvisi DF, Neumann O, Kolluru V, Wesely J, Chen X, Wang C, Wuestefeld T, Ladu S, Elgohary N, Bermejo JL, Radlwimmer B, Zornig M, Zender L, Dombrowski F, Evert M, Schirmacher P, Longerich T
    EEF1A2 inactivates p53 via PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma.
    Hepatology. 2013 Nov 28| PubMed Link | Link to the Journal

  • Lim L, Balakrishnan A, Juskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, , Brown D, Chang AN and Goga A
    mir-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of MCC
    Hepatology, Epub Aug., 2013| PubMed Link | Link to the Journal

  • Li L, Wang C, Calvisi DF, Evert M, Pilo M, Jiang L, Yuneva M and Chen X.
    SCD1 expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice
    PLoS one, Vol. 8(9), 2013, e75104| PubMed Link | Link to the Journal

  • Wang C, Cigliano A, Delogu S, Armbruster J, Dombrowski F, Evert M, Chen X#, and Calvisi D#. (#Co-corresponding authors)
    Functional crosstalk between AKT/mTOR and Ras/MAPK pathways in hepatocarcinogenesis: Implications for the treatment of human liver cancer
    Cell Cycle, 2013 Jun 6;12(13)| PubMed Link | Link to the Journal

  • Tschaharganeh DF, Chen X, , Latzko P, Malz M, Gaida MM, Felix K, Ladu S, Singer S, Pinna F, Gretz N, Sticht C, Tomasi ML, Delogu S, Evert M, Fan B, Ribback S, Jiang L, Brozzetti S, Bergmann F, Dombrowski F, Schirmacher P, Calvisi DF, Breuhahn K.
    Yes-Associated Protein Upregulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma
    Gastroenterology. 2013 Feb 15 | PubMed Link | Link to the Journal

  • Evert M, Dombrowski F, Biao F, Ribback S,Chen X, Calvisi DF.
    On the role of Notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development.
    Hepatology, 2012 Mar; 55(3):833-45 | PubMed Link | Link to the Journal

2012

  • Lingling Fan*, Chuanrui Xu*, Chunmei Wang, Junyan Tao, Coral Ho, Lijie Jiang, Bing Gui, Shiang Huang, Matthias Evert, Diego F. Calvisi, Chen X, .(*Co-first authors)
    Bmi1 Is Required for Hepatic Progenitor Cell Expansion and Liver Tumor Development.
    PLOS ONE. 2012 Sep 28.[Epub ahead of print] | PubMed Link | Link to the Journal

  • Fan B*, Malato Y*, Calvisi DF*, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X#, Willenbring H#.(*Co-first authors) (#Co-corresponding authors)
    Cholangiocarcinomas can originate from hepatocytes in mice.
    J Clin Invest. 2012 Jul 16. pii: 63212. doi: 10.1172/JCI63212. [Epub ahead of print] | PubMed Link | Link to the Journal

  • Chow EK, Fan LL, Chen X, Bishop JM
    Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells.
    Hepatology. 2012 Apr 13. doi: 10.1002/hep.25776. [Epub ahead of print] | PubMed Link | Link to the Journal

  • Wang CM*, Delogu S*, Ho C, Lee SA, Gui B, Jiang L, Ladu S, Cigliano A, Dombrowski F, Evert M, Calvisi DF#, Chen X#.(*Co-first authors) (#Co-corresponding authors)
    Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.
    J Hepatol. 2012 May 19. [Epub ahead of print] | PubMed Link | Link to the Journal

  • Fan B*, Dachrut S*, Coral H, Yuen ST, Chu KM, Law S, Zhang L, Ji J#, Leung SY#, Chen X#.(*Co-first authors) (#Co-corresponding authors)
    Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer.
    PLoS One. 2012;7(4):e29824. Epub 2012 Apr 23. | PubMed Link | Link to the Journal

  • Ho C*, Wang CM*, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X#, Calvisi DF#. (*Co-first authors) (#Co-corresponding authors)
    AKT and N-Ras co-activation in the mouse liver promotes rapid carcinogenesis via mTORC1, FOXM1/SKP2, and c-Myc pathways.
    Hepatology, 2012 Mar; 55(3):833-45 | PubMed Link | Link to the Journal

  • Yuneva MO, Fan TW, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Matés JM, Alonso FJ, Wang CM, Seo Y, Chen X, Bishop JM.
    The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
    Cell Metab. 2012 Feb 8; 15(2):157-70. | PubMed Link | Link to the Journal

2011

  • Calvisi DF#, Wang CM, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericssion J, Brizzetti, Staniscia T, Chen X#, Dombrowski F and Evert M . (#Co-corresponding authors)
    Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma
    Gastroenterology, Vol. 140, Mar. 2011, pp1071-1083 | PubMed Link | Link to the Journal

  • Powell DW, Pinchuk IV, Saada JI, Chen X and Mifflin RC
    Mesnechymal cells of the intestinal lamina propria
    Annual Review of Physiology, Vol. 73, Mar. 2011, pp213-237 | PubMed Link | Link to the Journal

  • Xu C, Lee SA and Chen X
    RNA Interference as Therapeutics for Hepatocellular Carcinoma
    Recent Patents on Anti-Cancer Drug Discovery, Vol. 6(1), Jan. 2011, pp106-115| PubMed Link | Link to the Journal

2010

  • Kosinski C, Strange DE, Xu C, Chan AS, Ho C, Yuen ST, Mifflin RC, Powell DW, Clevers H, Leung SY, Chen X
    Indian Hedgehog Regulates Intestinal Stem Cell Fate through Epithelial-Mesenchymal Interactions During Development.
    Gastroenterology, Epub Jun 10, 2010 | PubMed Link | Link to the Journal

  • Wei W, Li B, Hanes MA, Kakar S,Chen X and Liu L
    S-Nitrosylation from GSNOR Deficiency Impairs DNA repair and promotes hepatocarcinogenesis
    Science Translational Medicine, Epub Feb. 17, 2010 | PubMed Link | Link to the Journal

  • Lee SA, Ladu S, Evert M, Dombrowski F, Chen X# and Calvisin DF# (#Co-corresponding authors)
    Synergistic role of Spry2 inactivation and c-Met upregulation in mouse and human hepatocarcinogenesis
    Hepatology,2010 Aug;52(2):506-17 | PubMed Link | Link to the Journal

2009

  • Xu CR, Lee SA, Ho C, Huang SA, Cheung ST and Chen X,
    Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis
    Molecular Cancer Research, Vol. 7, Dec. 2009, pp1937-1945| PubMed Link | Link to the Journal

  • Chen X, Jorgenson E, Cheung ST
    New tools for functional genomic analysis
    Drug Discovery Today, Vol. 14, Aug. 2009, pp754-760| PubMed Link | Link to the Journal

  • Li VSW, Yuen ST, Cah TL, Chan ASY, Yan HHN, Law WL, Yeung BHY, Chan ASY, Tsui WY, So S, Chen X and Leung SY .
    Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms
    Gastroenterology, Vol. 137 (1), Jul. 2009, pp176-187 , | PubMed Link | Link to the Journal

  • Kakar S, Chen X, Ho C, Burgart LJ, Sahai V, Dachrut S, Yabes A, Jain D and Ferrell LD
    Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization
    Modern Pathology. 2001 Vol. 22(1), Jan. 2009, pp134-141| PubMed Link | Link to the Journal

  • Patil MA, Lee SA, Macias E, Lam ET, Xu C, Jones K, Ho C, Puebla M and Chen X
    Role of Cyclin D1 as a mediator of c-Met and β-Catenin induced hepatocarcinogenesis
    Cancer Research,. Vol. 69(1), Jan. 2009, pp253-261 | PubMed Link | Link to the Journal

  • Kakar S, Chen X, Ho C, Burgart L, Adeyi O, Jain D, Sahai V, Ferrell LD.
    Chromosomal abnormalities determined by comparative genomic hybridization are helpfully in the diagnosis of atypical hepatocellular neoplasms
    Histopathology , in press. | PubMed Link | Link to the Journal

2008

  • Lee SA, Ho C, Roy R, Kosinski C, Patil M, Tward A, Fridlyand J and Chen X.
    Integration of genomic analysis and in vivo transfection to identify Sprouty 2 as a candidate tumor suppressor.
    Hepatology,. Vol. 47(4), Apr. 2008, pp1200-1210| PubMed Link | Link to the Journal

2007

  • Chen D, Lewis R, Daigh C, Wang P, Kendziorski C, Ho C, Chen X, Thomson JA and Kendziorski C
    A microarray analysis of the emergence of embryonic definitive hematopoiesis
    Experimental Hematology ,Vol . 35, Aug. 2007, pp1344-1357 | PubMed Link | Link to the Journal

  • Saaf A, Halbleib JM, Chen X, Yuen ST, Leung SY, Nelson WJ and Brown PO
    Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal and colon cancer
    Mol. Biol. Cell , Epub Aug. 2007 | PubMed Link | Link to the Journal

  • Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R and Bishop JM
    Distinct cooperating mutations determine the outcome of tumorigenesis in mouse liver
    Proce Natl Acd Sci U S A , Epub Sept. 2007 | PubMed Link | Link to the Journal

  • Kosinski C, Li VSW, Chan ASY, Zhang J, Ho C, Tsui WY, Chan TL, Mifflin RC, Powell DW, Yuen ST, Leung SY and Chen X
    Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
    Proce Natl Acd Sci U S A , Epub Sept. 2007 | PubMed Link | Link to the Journal

  • Lowe AW, Olsen M, Hao Y, LeeSP, Taek K, Chen X van de Rijn M and Brown PO
    Gene expression patterns in pancreatic tumors, cells and tissues
    PLoS One , Vol (2), March 2007, E323 | PubMed Link | Link to the Journal

  • Segal E, Sirlin CB, Ooi C, Adler AD, Gollub J, Chen X, Chan BK, Matcuck GR, Barry CT, Chang HY, and Kuo MD
    Decoding global gene expression programs in liver cancer by noninvasive imaging
    Nature Biotechnology ,Vol 25(6), Jun. 2007, pp675-680 | PubMed Link | Link to the Journal

  • Berg JP, Zhou Q, Breuhahn K, Schirmacher P, Chen X, Patil MA, Schafer N, Bogdanow M, Buttner R and Gutgemann I
    Inverse expression of Jun Activation Domain Binding Protein 1 and cell cycle inhibitor p27Kip1: influence on proliferation in hepatocellular carcinoma
    Human Pathology , Epub July, 2007 | PubMed Link | Link to the Journal

  • Pankratz MT, Li XJ, Lyons EA, Chen X and Zhang SC
    Directed neural differentiation of hESCs via an obligated primitive anterior stage
    Stem Cells , Vol. 25(6), Jun. 2007, pp1511-1520 | PubMed Link | Link to the Journal

  • Ney JE, Zhou H, Sipos B, Kalthoff H, Buttner R, Chen X and Gutgemann I, Lippard SJ, Giacomin KM and Fan ST.
    PODXL-1 expression in pancreatic ductal adenocarcinoma is useful in the differentiation diagnosis of adenocarcinoms from the gastrointestinal and hepatobiliary tract
    Human Pathology , Vol. 38(2), Feb. 2007, pp359-364 | PubMed Link | Link to the Journal

2006

  • Zhang S, Lovejoy K, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Gray JW, Chen X , Lippard SJ, Giacomin KM and Fan ST.
    Organic cation transporters are determinants of oxaliplatin cytotoxicity
    Cancer Research , Vol. 66(17), Sept., 2006, pp8847-8857 | PubMed Link | Link to the Journal

  • Heukamp LC, Fisher HP, Schirmacher P, Chen X , Breuhahn K, Nicolay C, Buttner R and Gutgemann I.
    Podocalyxin-like protein 1 expression in primary human hepatic tumors and tumor like lesions
    Histophathology , Vol. 49, Jun. 2006, pp242-247 | PubMed Link | Link to the Journal

  • Ho JC, Cheung ST, Patil M,Chen X and Fan ST.
    Increased expression of GPI anchor attachment protein (GPAA1) is associated with gene amplification in hepatocellular carcinoma
    International Journal of Cancer , Vol. 119(6), Sept. 2006, pp1330-1337 | PubMed Link | Link to the Journal

  • Leung SY, Ho C, Tu IP, Li LY, Li R, So S, Chu KM, Yuen ST and Chen X.
    Comprehensive analysis of 19q12 amplicon in human gastric cancers.
    Modern Pathology , Vol 19(6), Jun. 2006, pp654-863. | PubMed Link | Link to the Journal

  • Patil MA, Zhang J, Ho C, Cheung ST, Fan ST and Chen X.
    Hedgehog signaling in human hepatocellular carcinoma.
    Cancer Biology and Therapy , Vol. 5(1), Jan. 2006, pp111-117. | PubMed Link | Link to the Journal

  • Aggarwal A, Guo DL, Hoshida Y, Yuen ST, Chu KM, So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY and Tan P
    Topological and functional discovery in a gene co-expression meta-network of gastric cancer.
    Cancer Research , Vol. 66(1), Jan. 2006, pp232-241.| PubMed Link | Link to the Journal |

2005

  • Wang YC, Juri D, Francisco B, Yu RX, Duran G, Chen K, Chen X and Sikic BI
    Regional activation of chromosome 7q with and without gene amplification in taxane-selected human ovarian carcinoma cell lines.
    Genes, Chromosomes and Cancer , Epub Dec. 2005. | PubMed Link | Link to the Journal

  • Patil MA, Gutgemann I, Zhang J, Ho C, Cheung ST, Gindinger D, Li R, Dykema KJ, So S, Fan ST, Kakar S, Furge KA, Buttner R and Chen X.
    Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as potential target for 8q gain in hepatocellular carcinoma.

    Carcinogenesis , Vol. 26, Dec. 2005, pp2050-2057. | PubMed Link | Link to the Journal |
  • Guo DL, Zhang J, Yuen ST, Tsui WY, Chan ASY, Ho C, Ji J, Leung SY and Chen X.
    Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumors.

    Carcinogenesis, Epub Nov. 2005. | PubMed Link | Link to the Journal

  • Giacomini C, Leung SY, Chen X, Yuen ST, KimY, Bair E, Tibshirani R, Pollack JR.
    A legacy gene-expression signature of genetic instability in colon cancer.

    Cancer Research , Vol. 65, Oct. 2005, pp9200-9205. | PubMed Link | Link to the Journal

  • Li VSW, Wong CW, Chan TL, Chan ASW, Zhao W, Chu KM, So S, Chen X, Yuen ST and Leung SY.
    Mutations of PIK3CA in gastric adenocarcinoma.
    BMC Cancer , Vol. 5(1), Mar. 2005: 29. | PubMed Link | Link to the Journal

  • Aavik E, Mahapatra A, Boldrick J, Chen X, Barry C, DuToit D, Sarwal M and Hayry P.
    Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury .
    FASEB Journal , Vol. 19(1), Jan. 2005, pp130-132. | PubMed Link | Link to the Journal

  • Lamba JK, Chen X, Lan KB, Kim JW, Relling MV, Kazuto Y, Watkins PB, Strom S, Sun D, Schuetz JD and Schuetz EG:
    Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.
    Pharmacogenetics , Vol. 16(6), Jun, 2005, pp415-427 | PubMed Link | Link to the Journal

  • Furge KA, Dykema KJ, Ho C, Chen X.
    Comparsion of array-based Comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma .
    BMC Genomics , Vol. 6(1), May 2005: 67. | PubMed Link | Link to the Journal |

  • Patil MA, Chua MS, Pan KH, Lin R, Lih CJ, Cheung ST, Ho C, Li R, Fan ST, Cohen SN, Chen X, So S.
    An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma.
    Oncogene. 2005 May 26;24(23):3737-47. | PubMed Link | Link to the Journal |

  • Cheung ST, Ho JC, Leung KL, Chen X, Fong DY, So S, Fan ST.
    Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy.
    Neoplasia. 2005 Feb;7(2):91-8. | PubMed Link | Link to the Journal |

  • Cheung ST, Leung KL, Ip YC, Chen X, Fong DY, Ng IO, Fan ST, So S
    Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma.
    Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):551-6. | PubMed Link | Link to the Journal |

2004

  • Cheung ST, Wong SY, Leung KL, Chen X, So S, Ng IO, Fan ST
    Granulin-Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma.
    Clin Cancer Res. 2004 Nov 15;10(22):7629-36.| PubMed Link | Link to the Journal

  • Leung SY, Yuen ST, Chu KM, Mathy JA, Li R, Chan AS, Law S, Wong J, Chen X, So S.
    Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer.
    Gastroenterology. 2004 Aug;127(2):457-69. | PubMed Link | Link to the Journal

  • West RB, Corless CL, Chen X, Rubin B, Subramanian S, Montgomery K, Zhu S, Ball CA, Mielsen TO, Patel R, Boldblum JR, Heinrich MC, van de Rijn M.
    The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status.
    Am J Pathol. 2004 Jul;165(1):107-13. | PubMed Link | Link to the Journal

  • Chen X , Higgins J, Cheung ST , Li R, Mason V, Montgomery K, Fan ST, van de Rijn M, and So S.
    Novel endothelial cell markers in hepatocellular carcinoma.
    Mod Pathol. 2004 May 21. | PubMed Link | Link to the Journal

  • Cui K, Tailor P, Liu H, Chen X, Ozato K and Zhao K.
    The chromatin-remodeling BAF complex mediates cellular antiviral activities by promoter priming.
    Mol Cell Biol. 2004 May;24(10):4476-86. | PubMed Link | Link to the Journal

2003

2002

  • Leung SY, Chen X, Chu KM, Yuen SY, Mathy J, Ji J, Chan A, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D and Brown PO.
    Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
    Proc Natl Acad Sci USA. 2002 Dec 10;99(25):16203-8. Epub 2002 Nov 27. | PubMed Link | Link to the Journal

  • Xu RH, Chen X, Chen DL, Li R, Addicks GC and Thomson JA.
    BMP4 initiates human embryonic stem cell differentiation to trophoblast.

    Nat Biotechnol. 2002 Dec;20(12):1261-4. Epub 2002 Nov 11. | PubMed Link | Link to the Journal

  • Ji J, Chen X, Leung SY, Chi J, Chu KM, Yuen SY, Li R, Chan A, Li J, Dunphy N and So S.
    Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines.

    Oncogene. 2002 Sep 19;21(42):6549-56. | PubMed Link | Link to the Journal

  • Liu H, Kan H, Liu R, Chen X and Zhao K.
    Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex.

    Mol Cell Biol. 2002 Sep;22(18):6471-9. | PubMed Link | Link to the Journal

  • Cheung ST, Chen X, Guan XY, Wong SY, Tai LS, Ng IO, So SK and Fan ST.
    Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumor.

    Cancer Res. 2002 Aug 15;62(16):4711-21. | PubMed Link | Link to the Journal

  • Chen X , Cheng ST , So SK, Fang ST, Barry C, Higgins J, Lai K, Ji J, Dudoit S, Ng I, vandeRijn M, Botstein D and Brown PO.
    Gene expression patterns in human liver cancers.

    Mol Biol Cell. 2002 Jun;13(6):1929-39. | PubMed Link | Link to the Journal

2001

  • Liu R, Liu H, Chen X, Martha K, Brown PO and Zhao K.
    Regulation of CSF1 promoter by the SWI/SNF-like BAF complex.
    Cell. 2001 Aug 10;106(3):309-18. | PubMed Link | Link to the Journal

  • Sarwal M, Chang S, Barry C, Chen X, Alizadeh A, Salvatierra O and Brown PO.
    Genomic analysis of renal allograft dysfunction using cDNA microarrays .
    Transplantation Proceedings , Vol. 33, Issues 1-2, 2001, pp297-298. | PubMed Link | Link to the Journal