Our lab regularly trains students from the UCSF Biophysics, Chemistry & Chemical Biology, and Tetrad graduate programs. Contact us if you’re interested in hearing more about our projects or rotating in the lab.
A post-doctoral position is available to study how molecular composition affects rates of enzyme-catalyzed reactions in biological condensates. Questions of ongoing interest are: 1-how does liquid-liquid phase separation repress enzyme activity, contrary to popular models of local concentration effects? 2- how do intrinsically disordered regions and their binding partners re-wire condensates from a repressed to an active state? 3-how are interactions that mediate condensate material properties on the mesoscale coupled to enzyme active site geometry at the Angstrom scale? 4-how does the transfer of short linear interaction motifs during evolution impact condensate function? The resolution of these questions will be enabled by tools and approaches we recently described for studies of the decapping enzyme complex, which can be applied to a variety of systems in RNA biology(Tibble et al, Nat Chem Biol, 2021). Candidates should have or expect a Ph.D. and should have demonstrated achievements in the biophysics of proteins and RNA. Expertise using NMR spectroscopy or related approaches to study the structure and dynamics of proteins or RNA is highly desirable.
Applications materials, including CV and contact information for three references, should be sent to:
jdgrosslab@gmail.com
with “post-doc position” written in subject line.