UCSF

Eligibility

Whom we seek

We seek people with these isolated limb malformations:

  • Arachnodactyly—Unusually long fingers compared to the length of the palm, also called achromachia.
  • Brachydactyly—Shortness of the fingers and/or toes relative to the length of other long bones.
  • Camptodactyly—A permanent flexion of one or more fingers.
  • Clinodactyly—A bend of the fifth finger (the pinky finger) towards the fourth finger.
  • Club foot—An inward twist and turn of the foot, also known as talipes equinovarus.
  • Congenital radial head dislocation—A dislocation of the elbow that may impede proper bending and flexing.
  • Congenital radioulnar synostosis—An abnormal development of the joints.
  • Isolated limb malformation—A limb malformation that occurs in the absence of any other clinical problem. It can also be referred to as a non-syndromic limb malformation.
  • Polydactyly—A presence of more than five fingers or toes on one hand or foot. The extra digit may consist of soft tissue, bone without joints, or a working digit.
  • Reduction anomalies—Less than five fingers or toes on one hand or foot.
  • Split hand and foot—An absence or one or more central digits of the hand or foot, also known as cleft hand or ectrodactyly.
  • Syndactyly—A fusion or webbing of digits. It can involve bones or only soft tissue.

You’re likely eligible to participate in our study if:

  • Your limb malformation is not associated with any other clinical problems, i.e., it is an isolated/non-syndromic limb malformation.
  • You have a family history of limb malformations.
  • Your mother had a normal pregnancy.
  • Your limb malformation is symmetrical (on both the right and left hands or feet).