UCSF

Tsinghua Faculty

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Research description

Potential UCSF collaborators

Jijie Chai, PhD

Professor

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The Chai laboratory is focused on structural and functional studies of biologically and medically important macromolecules, mainly through protein crystallography, in couple with biochemical, biological and other approaches, to gain insights into the structure-function relationship of these macromolecules.

Tanja Kortemme

Zhijie Chang, PhD

Professor

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The Chang laboratory studies signalling pathways, including the regulation of TGF-B signalling and differentiation of osteoblasts, the role of the JAK-STAT pathway in tumorigenesis and novel genes involved in Wnt signalling.

 

Chao Chen, PhD

Associate Professor

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The Chao laboratory is interested in organo-element chemistry and organic synthesis.

 

Ligong Chen, PhD

Principal Investigator

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The Chen laboratory studies the molecular pharmacology and physiology of SLC transporters using mouse models and various genomic and other -omics approaches.

Nadav Ahituv
Kathy Giacomini
Rada Savic

YongXiang Chen, PhD

Associate Professor

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The Chen laboratory develops methods for protein immobilization and labeling to elucidate the regulation of protein post-translational modifications on proteins function, localization and trafficking.

Lei Wang
William Degrado

Sheng Ding, PhD

Professor

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The Ding laboratory develops and applies innovative chemical approaches to stem cell biology and regeneration, with a focus on discovering and characterizing novel small molecules that can control cell fate and function of various cell types, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.

Su Guo
Tejal Desai
Hao Li
Charly Craik

Chen Dong, PhD

Professor

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The Dong laboratory is interested in studying the cellular and molecular mechanisms underlying immune responses with the goal of identifying new approaches of modulating the immune system in a variety of immune diseases and cancers.

Lei Wang

 

Liang Ge, PhD

Assistant Professor

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The Ge laboratory employs cutting edge techniques of cell biology and chemistry to study autophagy, including the mechanism of autophagic membrane formation, its role in degrading toxic protein aggregates and unconventional secretion.

 
 

Yan He, PhD

Professor

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The He laboratory is interested in non-fluorescence plasmonic imaging and the temporal-spatial behaviors of single nanoparticle probes in complex environments.

 

Zeping Hu, PhD

Principal Investigator

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The Hu laboratory using a variety of precise metabolic analytical techniques such as mass spectrometry to identify the metabolic disturbances in diseases, understand the underlying molecular mechanisms, and design optimal therapeutic strategies.

 

KehKooi Kee, PhD

Professor

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The Kee laboratory focuses on understanding reproductive biology, especially germ cell formation, initiation of meiosis, and impacts of germ cells on early human embryo development.

 

Haitao Li, PhD

Principal Investigator

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The Li laboratory uses mainly structural biology approaches blended with other biochemical, chemical biological, and cell biology techniques to study key molecular recognition and catalysis events involved in epigenetic regulation.

Tanja Kortemme

 

Jinghong Li, PhD

Professor

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The Li laboratory is interested in electroanalytical chemistry and bioanalysis, nanoanalysis and biosensing, physical electrochemistry and interfacial electrochemistry, material electrochemistry and nanoscopic electrochemistry, and energy conversion and storage.

Tejal Desai

Yanmei Li, PhD

Professor

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The Li laboratory studies bioorganic chemistry, biotransformation reactions and biological membranes and proteins.

William Degrado

Xueming Li, PhD

Principal Investigator

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The Li laboratory focuses on the theoretical and methodological development of cryo electron microscopy (CryoEM) and its applications in structural biology to address important biological questions.

Yifan Cheng
William Degrado

Xin Liang, PhD

Principal Investigator

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The Liang laboratory is interested in the molecular basis of fly mechanosensory transduction, morphological control of fly sensory neurons and microtubule instability.

Deanna Kroetz

Gang Liu, PhD

Professor

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The Liu laboratory performs phenotype screening with small molecule libraries to identify novel treatments for cancers and infectious diseases.

Su Guo
Rada Savic

Lei Liu, PhD

Professor

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The Liu laboratory is interested in synthetic bioorganic chemistry involving chemical synthesis and modification of proteins and catalytic synthesis of bioactive small molecules.

Lei Wang

Zhi John Lu, PhD

Associate Professor

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The Lu laboratory is interested in post-transcriptional regulation of coding and noncoding RNAs, characterization of novel RNA biomarkers in cancer, and developing cutting-edge machine learning methods of the analysis of genomic data.

Nadav Ahituv

 

Jie Na, PhD

Principal Investigator

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The Na laboratory is interested in the molecular mechanism of human pluripotent stem cell differentiation, genetic instability in early mammalian embryos and cardiovascular tissue engineering and 3D bioprinting.

Tejal Desai

Feng Qian, PhD

Principal Investigator

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The Qian laboratory seeks to address drug delivery problems, including enhancing the solubility of small molecules using amorphous or nano-crystalline technologies, understanding the physical interactions of protein-based therapeutics, and developing novel drug delivery systems to manipulate the tumor microenvironment.

Tejal Desai

Yefeng Tang, PhD

Principal Investigator

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The Tang laboratory seeks to discover and develop new chemical reactions and strategies that enable the rapid production of biologically important molecules.

 

Dong Wang, PhD

Principal Investigator

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The Wang laboratory is trying to understand the mechanisms underlying regulated gene expression and transcriptional programming/reprogramming in cancer cells during tumorigenesis by utilizing combined genomic, epigenomic and chemical genomic approaches.

 

Hong-Wei Wang, PhD

Professor

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The Wang laboratory is devoted elucidating the architecture and mechanism of macromolecular complexes and assemblies with cryo-electron microscopy.

Alan Frankel
Yifan Cheng

Jianbin Wang, PhD

Assistant Professor

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The Wang laboratory focuses on the development of novel genomic technologies and their application on biomedical research, including microfluidics and high-throughput sequencing.

Nadav Ahituv
Alan Frankel

Zhao Wang, MD, PhD

Professor

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The Wang laboratory maintains an interest in neuropharmacology and metabolic pharmacology, especially as it comes to the aging process.

Hao Li

Bailong Xiao, PhD

Principal Investigator

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The Xiao laboratory studies sensory ion channels to understand the molecular and cellular mechanisms behind the sense of touch and pain.

Deanna Kroetz
Lei Wang

Lin Xin, PhD

Professor

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The Xin lab is focused on basic biology and the clinical application of the immune system to cancer. The goal is to determine the molecular mechanisms by which NF-kB is activated by various signaling pathways, and to investigate the mechanism by which NF-kB is linked to T lymphocyte activation, inflammation and its contribution to the malignancy of various cancers.

Alan Frankel

Huaping Xu, PhD

Professor

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The Xu laboratory conducts research on selenium-containing polymers.

 

Yong-Bin Yan, PhD

Principal Investigator

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The Yan laboratory studies the structure, components, folding, assembly, physiological and pathological roles of cellular bodies including aggresomes/inclusion bodies and RNA granules via biophysical, biochemical and cellular methods.

 

Hang Yin, PhD

Professor

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The Yin laboratory develops drug candidates that can improve opioid-based pain management therapies using structure-based drug design, cell signaling biochemistry, biotechnology development, and membrane protein simulations.

 

Michael Qiwei Zhang, PhD

Professor

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The Zhang laboratory uses high-throughput techniques and high-performance computer simulations to study cell development, differentiation, apoptosis, gene regulation and metabolic networks.

Hao Li

Qiangfeng Cliff Zhang, PhD

Principal Investigator

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The Zhang laboratory develops novel enabling techniques that use computation and high throughput experimentation for the study of structural systems biology.

Nadav Ahituv
Tanja Kortemme

Wei Zhang, PhD

Principal Investigator

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The Zhang laboratory characterizes the mechanosensitive channels and neural circuits underlying hearing, somatosensation and other mechanosensory modalities.

Su Guo
Deanna Kroetz