UCSF

UCSF Faculty

Photo

Who

Research description

Potential Tsinghua collaborators

Nadav Ahituv, PhD

Professor

Email

The Ahituv laboratory is focused on understanding the role of regulatory sequences in human biology and disease. Through a combination of comparative genomic strategies, biochemical assays, regulatory element analysis, human patient samples, mouse and fish genetic engineering technologies, and massively parallel reporter assays they are working to elucidate mechanisms whereby genetic variation within these sequences lead to changes in human phenotypes.

Ligong Chen
Qiangfeng Cliff Zhang
Jianbin Wang
Zhi John Lu

Michelle Arkin, PhD

Professor

Email

The Arkin laboratory develops innovative approaches to screen for chemical tools and drug leads, using biophysical approaches like fragment-based drug discovery and biological approaches including high-content imaging with primary cells and organisms.

 

Leslie Benet, PhD

Professor

Email

The Benet laboratory performs research on the correlation of pharmacokinetics and pharmacodynamics for drugs in various patient populations, with emphasis on the relevance of specific metabolic enzymes and drug transporters.

Ligong Chen

Yifan Cheng, PhD

Professor

Email

The Cheng laboratory is interested in studying the three-dimensional structures of macromolecular complexes: their structural architectures, the regulation of their function and the dynamic processes of their assembly and disassembly, by molecular electron microscopy (cryoEM).

Hongwei Wang
Xueming Li

Charles Craik, PhD

Professor

Email

The Craik laboratory uses a combination of genetic, biochemical, and biophysical methods, with particular emphasis on identifying the roles and regulating the activity of proteases associated with infectious diseases, cancer, and development.

Sheng Ding

William Degrado, PhD

Professor

Email

The Degrado laboratory focuses on small molecule and protein design as an approach to understanding macromolecule structure and function.

Xueming Li
Yanmei Li
YongXiang Chen

Tejal Desai, PhD

Professor

Email

The Desai laboratory brings together advanced micro and nanotechnologies, fundamental insight into cellular behavior in engineered environments, and novel pharmacologic delivery approaches to address disease treatment and clinical translation.

Feng Qian
Sheng Ding
Jie Na
Jinghong Li

Alan Frankel, PhD

Professor

Email

The Frankel laboratory focuses on RNA-protein recognition and the assembly of RNA-based regulatory complexes.

Hongwei Wang
Jianbin Wang
Lin Xin

Zev Gartner, PhD

Associate Professor

Email

The Gartner laboratory uses a synthetic approach to understand tissue structure form and function by building human tissues from the bottom-up. This approach allows the group to measure and perturb the molecular and physical properties of individual cells, reconstitute them into living tissue, then observe their interactions to reveal the underlying "rules" guiding their collective behavior.

 

The Giacomini laboratory focuses on expanding our understanding of membrane transporters. Membrane transporters are of great pharmacological importance, as they play a major role in drug efficacy by regulating drug disposition and distribution.

Ligong Chen

Su Guo, PhD

Professor

Email

The Guo laboratory aims to fundamentally understand how the brain works, which is key to treating developmental, degenerative, and psychiatric neurological disorders.

Gang Liu
Wei Zhang
Sheng Ding

Michael Keiser, PhD

Assistant Professor

Email

The Keiser laboratory combines machine learning and chemical biology methods to investigate how small molecules perturb entire protein networks to achieve their therapeutic effects

 

Tanja Kortemme, PhD

Professor

Email

The Kortemme laboratory aims to invent approaches to engineer new molecules that operate as predicted in biological contexts, and to utilize prediction and engineering to address fundamental questions on the relationship of molecular characteristics, cellular function and organismal fitness.

Jijie Chai
Qiangfeng Cliff Zhang
Haitao Li

Deanna Kroetz, PhD

Professor

Email

The Kroetz laboratory investigates genetic differences in drug response and searches for new drug targets to treat kidney disease.

Bailong Xiao
Wei Zhang
Xin Liang

Hao Li, PhD

Professor

Email

The Li laboratory works on developing novel algorithms for analyzing the regulatory regions of genomes and transcriptional regulation on a genomic scale, developing tools for analyzing gene regulatory networks using gene expression and protein-protein interaction data, and protein sequence and structure analysis.

Sheng Ding
Zhao Wang
Michael Zhang

Andrej Sali, PhD

Professor

Email

The Sali laboratory aims to develop and apply computational methods for integrative determination of the structures and dynamics of macromolecular assemblies, in turn informing the function and evolution of these systems as well as how to modulate them.

 

Rada Savic, PhD

Associate Professor

Email

The Savic laboratory uses computational methods to study the dynamic interplay between disease progression, drug and biomarker response across relevant scales (molecule, cell, tissue, organ & whole body) in order to determine causal links underlying variability in (safety and efficacy) clinical outcomes.

Gang Liu
Ligong Chen

Lei Wang, PhD

Associate Professor

Email

The Wang laboratory focuses on expansion of the genetic code to incorporate unnatural amino acids into proteins; these new amino acids are designed and harnessed to understand protein and cellular function and to develop biotherapeutics.

Bailong Xiao
Tongxiang Chen
Lei Liu
Chen Dong