Research laboratory of William DeGrado, PhD

People

Principal investigator

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Who

Research Interests

William DeGrado, PhD

William DeGrado, PhD
Professor and Principal Investigator
william.degrado@ucsf.edu

De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design

Senior scientists

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Who

Research Interests

Hyunil Jo, PhD

Hyunil Jo, PhD
Specialist, Lab Manager
hyunil.jo@ucsf.edu

Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life

Yibing Wu, PhD

Yibing Wu, PhD
NMR Specialist
ybwu01@gmail.com

Structure and dynamics of proteins using multidimensional NMR spectroscopy; structural studies of the M2 protein from influenza

Postdoctoral scholars

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Who

Research Interests

Manasi Bhate

Manasi Bhate, PhD
Postdoctoral Scholar
manasi.bhate@ucsf.edu
Website

Mechanistic basis of transmembrane signal transduction by protein design, NMR spectroscopy, and biophysics; structure and dynamics of histidine kinases

Bobo Dang

Bobo Dang, PhD
Postdoctoral Scholar
bobo.dang@ucsf.edu

Protein/peptide therapeutics

Thomas Lemmin, PhD

Thomas Lemmin, PhD
Postdoctoral Scholar
thomas.lemmin@ucsf.edu

Integrative molecular modeling of oligomeric proteins; structural refinement and dynamics using molecular dynamics simulations

Michelle McCully, PhD

Michelle McCully, PhD
Postdoctoral Scholar
michelle.mccully@ucsf.edu
Website

Computational and experimental biophysical techniques to elucidate the structure and dynamics of the HIV gp41 protein, design an HIV vaccine, and investigate HIV fusion

Kathleen Molnar, PhD

Kathleen Molnar, PhD
Postdoctoral Scholar
kathleen.molnar@ucsf.edu

Dynamics of membrane protein signaling; specifically the structural changes that occur in bacterial histidine kinases, such as PhoQ

Mimi Nick, PhD

Mimi Nick, PhD
Postdoctoral Scholar
mimi.nick@ucsf.edu

Amyloidogenesis; structure of amyloid fibril strains; dynamics of Aβ oligomers associated with Alzheimer’s disease

Nathan Schmidt, PhD

Nathan Schmidt, PhD
Postdoctoral Scholar
nathan.schmidt@ucsf.edu

Bacterial systems which detect host defense antimicrobial peptides; role of bacterial response to antimicrobials in virulence and resistance; two-component system signaling in microbes

Gozde Ulas

Gözde Ulas, PhD
Postdoctoral Scholar
gozde.ulas@ucsf.edu

Accessing and modulating reactivity of de novo metalloproteins by protein design, biochemical, and biophysical methods

Haifan Wu

Haifan Wu, PhD
Postdoctoral Scholar
haifan.wu@ucsf.edu

Stapled peptides targeting protein-nucleic acid interactions; specific imaging agents for integrin αvβ1

Shaoqing Zhang, PhD

Shao-Qing Zhang, PhD
Postdoctoral Scholar
zhangsh@sas.upenn.edu

Design de novo helix bundles, water soluble or membrane associated; build model systems for folding and/or functional studies; invent nanomaterials for biological applications

Graduate students

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Who

Research Interests

Leo Gendelev

Leo Gendelev
Biophysics (BP) program
leo.gendelev@ucsf.edu

Designed proteins that can modulate protein-protein interactions; computational methods and directed evolution techniques; mining the protein data bank for interaction motifs

Bruk Mensa

Bruk Mensa
Chemistry and Chemical Biology (CCB) program
bruk.mensa@ucsf.edu

Structure and signal transduction mechanism of bacterial two component system histidine kinases; mechanism of action of antimicrobial peptide mimetics

Marco Mravic

Marco Mravic
Biophysics (BP) program (iPQB)
marco.mravic@ucsf.edu

Data driven protein engineering; de novo membrane protein and enzyme design; protein evolution; catalysis; microfluidic directed evolution; machine learning

Jessica Thomaston

Jessica Thomaston
Chemistry and Chemical Biology (CCB) program
jessica.thomaston@ucsf.edu

Membrane protein structure using x-ray crystallography; influenza M2 proton channel structure, mechanism, and drug resistance

Visiting scholars

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Who

Research Interests

Sid Das

Sid Das, PhD
Visiting Professor
siddhartha.das@ucsf.edu

Making protein matrix for drug release

Hailin Hu

Hailin Hu
Undergraduate Student
Tsinghua University, Bejing, China
hailin.hu@ucsf.edu

Exploring folding determinants of membrane proteins using designed, helix-bundle model systems; design and engineering of metalloproteins as catalysts

Kazutoshi Takahashi, PhD

Kazutoshi Takahashi, PhD
Researcher
Ajinomoto Co. Inc., Kawasaki, Japan
kazutoshi.takahashi@ucsf.edu

De novo design of proteins using both computational and experimental methods

Administrative staff

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WHO

WHAT I DO

Lili Li

Lili Li
Administrative Analyst
lili.li@ucsf.edu

Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars