| Photo | Who | Research interests |
|---|---|---|
Principal investigator | ||
| Rada Savic, PhD Principal Investigator | I work on methodological advancement and application of systems pharmacology models to drug development and therapy optimization problems in tuberculosis (TB), HIV, oncology, and diabetes. |
Lab members | ||
| Belén Pérez Solans, PhD Postdoctoral Scholar | I work on computational methods to study the interplay between longitudinal dynamics of drug and biomarkers, and disease, with a focus on paediatric population PK and PD, and model-informed precision dosing for tuberculosis (TB) and oncology. |
| Agathe Béranger, MD, PhD Postdoctoral Scholar | I work in PICU and I have a real interest in PK. The two disciplines together allow us to understand the physiopathological changes occurring in critically ill children and their impact on the pharmacokinetics of anti-infectious drugs. The goal is to achieve optimal prescription in this vulnerable population. |
| Ségolène Siméon, PharmD, PhD Genentech Fellow | In order to determine the impact of human phenotype on recommended malaria treatments, I use computational models to optimize dosing regimens according to the patients and their physiological characteristics. |
| Pieter Van Brantegem, PharmD, PhD Postdoctoral Scholar | My research interests include PK and PD modeling of therapies to treat infectious diseases. Currently, I focus on improving combination drug regimens for tuberculosis with the aim to better understand optimal dosing strategies that provide high cure rates. |
| Rob Christiaan van Wijk, PhD Postdoctoral Scholar | I am passionate about translational pharmacology and how it enables us to predict unknown scenarios in preclinical and clinical contexts based on our understanding of the underlying quantitative relationship that drive therapeutic efficacy. It is a collaborative effort where all different expertises in experimental, clinical, and computational domains come together to answer the relevant questions in drug development and health care. |
| Marjorie Imperial, PhD Postdoctoral Scholar | I am developing computational models that investigate the variability observed in drug response. Ultimately, the goal is to apply these models to provide personalized medicine for improved diagnosis, therapies, and prognosis of diseases. |
| Ryo Miyakawa, MD, MPH Clinical Pharmacology Fellow | I am a pediatric pulmonologist, who is currently an infectious disease fellow. I am interested in how pharmacokinetics are affected by the gut microbiome and nutritional status in the treatment of chronic respiratory tract infections, such as tuberculosis. |
| Jordan Brooks, PharmD Clinical Pharmacology Fellow, Joint mentorship with Dr. Janel Long-Boyle | My interest is in PK/PD modeling of narrow therapeutic window medications utilized in pediatric bone marrow transplant and translating such models into clinically useful tools to enable model-informed dosing and help improve patient outcomes. |
| Erika Wallender, MD, MPH | I am interested in improving how antimalarials are used for malaria treatment and prevention in pregnant women and children by using PK/PD modeling to relate antimalarial drug exposure to toxicity, clinical and preventive efficacy, and drug resistance. Our clinical work is conducted in a collaboration between UCSF and the Infectious Diseases Research Collaboration in Kampala, Uganda. |
| Janice Goh Graduate Student | I am interested in the involvement of the microbiome in host gene expression and how these gene changes can affect host metabolism and clearance. I utilize a variety of experimental methods including microbiology, gnotobiotics and next generation sequencing as well as computational methods like PK modeling to answer this question. |
| Emma Hughes Graduate Student | I am developing computational models to investigate the effects of patient and disease characteristics on malaria prevention and treatment strategies. Our target populations are young children and pregnant women given their vulnerability to malaria. Ultimately, our goal is to provide optimized dosing recommendations to inform clinical practice and policies. |
| Jackie Ernest Graduate Student | I am developing translational tools to better predict clinical outcomes using preclinical data. Currently, I am using a rabbit model of tuberculosis to rank drugs and optimize dose for lesion-centric efficacy and sterilization. |
| Vincent Chang Graduate Student | I am using computational methods to investigate novel tuberculosis biomarkers or combinations of biomarkers that can adequately monitor disease progression, follow early treatment response, and predict long term clinical outcomes. |
| Anu Patel, PharmD Graduate Student
| I am interested in informing and advancing the development of safe and effective therapies for patients with tuberculosis globally, through PK/PD modeling and clinical trial design of novel drug combination regimens. Through these efforts, I hope to work towards ensuring that each patient receives the optimal treatment for curing their disease. |
| Hoang-Anh Vu Graduate Student | I am researching translational methods to accelerate development of therapeutics across the drug development pipelines. Currently, I am working on PKPD modeling of drug delivery for optimization of TB lesion-specific dosage. |
| Ava Xu, PharmD Graduate Student | I am interested in developing methodology that incorporates pharmacogenomics data to better predict PKPD parameters. Ultimately, the goal is to use such models to provide personalized recommendations for patients and to guide clinical trial designs. |
| Connie Silva Graduate Student | I’m interested in translating complex biology into quantitative/mathematical models to answer key drug development questions that can influence dosing or help predict drug-drug interaction. The goal is to harness the predictive power of these models to shape the development of effective drug therapies and ensure that the right drug reaches the right patients. |
| Eunsol Yang, PharmD, PhD Postdoctoral Scholar | My research interests lie in translational sciences based on pharmacometrics and clinical pharmacology. Currently, I work on computational modeling to quantify dose-exposure-response relationship and explore factors affecting PK or PD, with a focus on tuberculosis. This work can bridge the knowledge gap in drug development and clinical application, ultimately contributing to optimized pharmacotherapy and global health. |
| Annamarie Bustion, PhD Postdoctoral Scholar | Previously I researched the ability of bacteria in the human gut microbiome to break down therapeutics intended for their human host. As a post-doc in the Savic lab, I am currently researching spatio-temporal modeling methods that reflect drug penetration into caseum (hard-to-reach lung lesions that allow M. tuberculosis to persist in its host) |
Staff | ||
| Craig Shaffer Director, Research Strategy & Operations | I am a dedicated and experienced problem-solver passionate about providing global-health and infectious-disease insight, innovation, and impact through data-driven modeling and decision analytics. |
| Alexander "Sandy" Floren Research Data Analyst | My research interests lie in the development and application of computational methods for the improvement of human health and longevity, particularly in vulnerable populations. Currently I am using simulation-based approaches to investigate the impact of malnutrition on HIV and TB drug exposure in young children. |
Former lab members
| Who | Formerly | Now |
|---|---|---|
| Alfonz Suguitan | Project Policy Analyst | UC Davis |
| Lorenzo Flori, MS, PharmD | Visiting Scholar | PhD Student at Università di Pisa |
| Mikhail (Michael) Zastrozhin, PhD | Postdoctoral Scholar | Cofounder of PharmacoGenomeX2 |
| Anna Fochesato, MS | Visiting Scholar | PhD Student at The University of Trento (COSBI) |
| Erwin Dreesen, PhD | Visiting Scholar | Assistant Professor of Pharmacometrics at KU Leuven |
| Natasha Strydom, PhD | Postdoctoral Scholar | Senior Scientist, Amgen |
| Kendra Radtke, PharmD | Graduate Student | Clinical Pharmacology and Therapeutics Fellow in the Butte Lab at UC San Francisco |
| Hwi-yeol (Thomas) Yun, PhD | Visiting Scholar | Associate Professor, College of Pharmacy, Chungnam National University |
| Huy Ngo, PharmD, PhD | Postdoctoral Scholar | Genentech-CERSI Clinical Pharmacology Fellow |
| Maria Garcia-Cremades Mira, PhD | Postdoctoral Scholar | Assistant Professor in the School of Pharmacy in la Universidad Complutense de Madrid |
| Isaac Cohen, PharmD | T32 Clinical Pharmacology Fellow | Clinical Pharmacologist at Denali Therapeutics |
| Leah Gonzalez Jarlsberg | Research Data Analyst | Research Analyst at UCSF Pulmonary & Critical Care Division |
| Veronika Westergren | Visiting Scholar | Graduate student at Uppsala University |
| Nan Zhang, PhD | Academic Coordinator | Senior Clinical Pharmacokineticist at AstraZeneca |
| Priya Jayachandran, PharmD, MS | Clinical Pharmacology Fellow | Pharmacometrician at Pfizer |
| Peter Lu | Administrative Analyst | Research Data Analyst at UCSF |
| Amelia Deitchman, PharmD, PhD | Clinical Pharmacology Fellow | T32 Clinical Pharmacology Fellow at UCSF |
| Daniel Chan, PhD | Postdoctoral Scholar | Scientist at BioMarin Pharmaceutical Inc |
| William Fox, MS | Research Data Analyst | Computer Vision Engineer at Presto |
| Sarah Shaffer, MA | Writer | Web & Content Editor at The Wonder Kid |
| Katarina Vucicevic, PhD | Visiting Scholar | Assistant Professor at University of Belgrade |
| Michael Martin, PhD | Postdoctoral Scholar | Associate at Prescient Healthcare Group |
| Ron Keizer, PhD | Postdoctoral Scholar and Research Scientist | CSO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing |
| Sirj Goswami, PhD | PhD student in Pharmaceutical Sciences and Pharmacogenomics | CEO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing |
| Jennifer Hibma, PharmD | Postdoctoral Scholar | Quantitative clinical pharmacologist at Pfizer |
| Yookhwan Noh, PhD | Postdoctoral Scholar | Assistant professor at Ulsan University Hospital |
| Sneha Gupta, PhD | Clinical Pharmacology Fellow | Clinical pharmacologist at Gilead Sciences, Inc. |
| Jodi Parikh, PhD | Visiting Scholar | Postdoc at Rutgers New Jersey Medical School |
| Allison Komirenko | Visiting Scholar | Biotech Clinical Research Fellow at Achaogen |
| Viktoria Grahnen, MSc | Junior Specialist | Labeling Strategist Manager at AbbVie |
| Malte Larsen, MSc | Junior Specialist | PhD Student at University of Copenhagen |
| John Fors, MS, NP-C | Specialist | Nurse Practitioner at Stanford Health Care |
| Desiree Legetth, MSc | Junior Specialist | Quality Assurance Officer at AstraZeneca |
| Niels Erik Olesen, PhD | Junior Specialist | Postdoc at Center for Research, University of Copenhagen |
| Ana Kalezic, MSc | Junior Specialist | PhD student at Uppsala University |
| Benjamin Guiastrennec, PharmD, MS | Visiting Graduate Student | PhD Student at Uppsala University |
| Yusi Chen | Visiting Graduate Student | Graduate Student at Tsinghua University |
| Imke Bartelink, PhD | Clinical Pharmacology Fellow | Senior Pharmacometrician at MedImmune |
| Daniel Chan, PhD | Postdoctoral Scholar | Scientist at BioMarin Pharmaceutical Inc |
| Andrew Gewitz, PhD | Postdoctoral Scholar | Clinical Pharmacologist at Regeneron |
| Stella Belonwu, BS | Graduate Student | Graduate Student at UCSF |