Publications

Independent career

  1. Sapiro, A.L.; Hayes, B.M.; Volk, R.F.; Zhang, J.Y.; Brooks, D.M.; Martyn, C.; Radkov, A,; Zhao, Z.; Kinnersley, M.; Secor, P.R.; Zaro, B.W.; Chou, S. Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorgeri during tick-borne transmission. In Revision. eLife Preprint: 10.1101/2022.11.09.515847
  2. Chen, Z.; Mondal, A.; Abderemane-Ali, F.; Montaño, J.L.; Zaro, B.W.; Minor, D.L. EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms. Accepted. Nature DOI: 10.1101/2022.10.03.510667
  3. Datta, R.; Gholampour, M.A.; Yand, C.D.; Volk, R.F.; Lin, S.; Podolsky, M.J.; Arnold, T.; Rieder, F.; Zaro, B.W.; Verzi, M.; Lehner, R.; Abumrad, N.; Lizama, C.O.; Atabai, K. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4g-dependent transcription of CES enzymes. Cell Rep (2023) 42(3):112249. PMID: 36924494
  4. Zhang, K.; Yao, E.; Chuang, E.; Chen, B.; Chuang, E.Y.; Volk. R.F.; Zaro, B.W.; Chuang, P.T. Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. PLOS Biol (2022) 20(8):e3001759. PMID: 36026468
  5. Dang, E.; Lei, S.; Radkov, A.; Volk, R.F.; Zaro, B.W.; Madhani, H. Secreted fungal effector triggers allergic inflammation via Toll-like receptor 4 to enable lethal infection. Nature (2022) 608: 161-7. PMID: 35896747
  6. Volk, R.F.; Montaño, J.L.; Warrington, S.E.; Hofmann, K.; Zaro, B.W. Proteomic Characterization of Phagocytic Primary Human Monocyte-Derived Macrophages. RSC Chem. Biol. (2022) 3(6): 783-793. PMID: 35755185
  7. Montaño, J.L., Wang, B.; Volk, R.F.; Garda, V.G.; Zaro, B.W. Improved Electrophile Design for Exquisite Covalent Molecule Selectivity. ACS Chem. Biol. (2022) 17(6), 1440-9. PMID: 35587148
  8. Pedowitz, N.J.; Zaro, B.W.; Pratt, M.R. Metabolic labeling for the visualization and identification of potentially O-GlcNAc modified proteins. Current Protocols in Chemical Biology. (2020) e81. PMID: 32289208
  9. Darabedian, N.; Yang, B.; Ding, R.; Zaro, B.W.; Woo, C.; Pratt, M.R. O-Acetylated chemical reporters of glycosylation can display metabolism-dependent background labeling of proteins but are generally reliable tools for the identification of glycoproteins. Frontiers in Chemistry. (2020), 8 (318). PMID: 32411667

Post-doctoral

  1. Zaro, B.W.*▵; Noh, J.J.*; Mascetti, V.L.; Demeter, J., George, B.M.; Zukowska, M.; Gulati, G.S.; Sinha, R.; Flynn, R.A.; Banuelos, A.; Zhang, A.; Wilkinson A.C.; Jackson P.K.; Weissman I.L.▵; Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells. eLife 2020;9:e62210. *Equal Contribution ▵Co-Corresponding PMID: 33236985
  2. Barkal, A.; Brewer, R.; Markovic, M.; Kowarsky, M.; Barkal, S.; Zaro, B. W.; Krishnan, V.; Hatakeyama, J.; Dorigo, O.; Barkal, L.; Weissman, I. L. CD24 signalling through macrophage Siglec-10 is a new target for cancer immunotherapy. Nature. (2019) 138(5), 286-5. PMID: 31367043
  3. Bouffard, E., Zaro, B. W., Dix, M. M., Cravatt, B. & Wong, C.-H. Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity. Tetrahedron Lett (2021) 74, 153178. PMID: 34764521
  4. Senkane, K.; Vinogradova, E.V.; Suciu, R.M.; Crowley, V.M.; Zaro, B.W.; Bradshaw J.M.; Brameld, K.A.; Cravatt, B.F. The Proteome-Wide Potential for Reversible Covalency at Cysteine. Angew. Chem. Int. Ed. (2019) 58(33), 11385-11389. PMID: 31222866
  5. Zaro, B. W.; Vinogradova, E.; Lazear, D.; Blewett, M. M.; Suciu, R.; Takaya, J.; Studer, S.; de la Torre, J. C.; Cravatt, B.F.; Teijaro, J. R. Dimethyl fumarate disrupts human innate immune signaling by targeting IRAK4-MyD88 complex. J. Immunol. (2019) 202(9), 2737-2746. PMID: 30885957
  6. Zaro, B. W.; Whitby, L. R.; Lum, K. M.; Cravatt, B. F. Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors. J. Am. Chem. Soc. (2016) 138 (49), 15841-4. PMID: 27960302
  7. Blewett, M. M.; Xie, J.; Zaro, B. W.; Backus, K. M.; Altman, A.; Teijaro, J. R.; Cravatt, B. F. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci. STKE. (2016) 9 (445), rs10. PMID: 27625306

Graduate school

  1. Walter, L. A.; Batt, A. R.; Darabedian, N.; Zaro, B. W.; Pratt, M. R. Azide- and alkyne-bearing metabolic chemical reporters of glycosylation show structure-dependent feedback inhibition of the hexosamine biosynthetic pathway. Chembiochem. (2018) 19(18), 1918-1921. PMID: 29979493
  2. Chuh, K. N.; Batt, A. R.; Zaro, B. W.; Darabedian, N.; Marotta, N. P.; Brennan, C. N.; Amirhekmat, A.; Pratt, M. R. The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8. J. Am. Chem. Soc. (2017) 139(23), 7872-7885. PMID: 28528544
  3. Batt, A. R.; Zaro, B. W.; Navarro, M.; Pratt, M. R. Metabolic chemical reporters of glycans exhibit cell-type selective metabolism and glycoprotein labeling. ChemBioChem. (2017) 12 (3), 787-794. PMID: 28231413
  4. Zaro, B. W.; Batt, A.; Chuh, K. N.; Navarro, M.; Pratt, M. R. The small molecule 2-azido-2-deoxy-glucose is a metabolic chemical reporter of O-GlcNAc modifications in mammalian cells, revealing an unexpected promiscuity of O-GlcNAc transferase. ACS Chem. Biol. (2017) 12 (3), 787-794. PMID: 28135057
  5. Marotta, N. M.; Lin, Y. H.; Lewis, Y. E.; Ambroso, M.; Zaro, B. W.; Roth, M. T.; Arnold, D. B.; Langen R.; Pratt, M. R. O-GlcNAc modification blocks the aggregation and toxicity of the Parkinson’s Disease associated protein α-synuclein. Nat. Chem. (2015) 7, 913-920. PMID: 26492012
  6. Chesarino, N. M.; Hach, J. C.; Chen, J. L.; Zaro, B.W.; Rajaram, M.; Turner, J.; Schlesinger, L. S.; Pratt, M.R.; Hang, H. C.; Yount, J. S. Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biology (2014), 12(1), 91. PMID: 25371237
  7. Zaro, B. W.; Chuh, K. N.; Pratt, M. R. Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification. ACS Chem. Biol. (2014), 9(9), 1991–1996. PMID: 25062036
  8. Chuh, K. N.*; Zaro, B. W.*; Piller F.; Piller V.; Pratt, M. R. Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification, J. Am. Chem. Soc. (2014) 136(35), 12283–12295. *equal contribution PMID: 25153642
  9. Gurel, Z.; Zaro, B. W.; Pratt, M. R.; Sheibani, N. Identification of O-GlcNAc Modification Targets in Retinal Pericytes, PLoS One (2014) 9, e95561. PMID: 24788674
  10. Zaro, B. W.; Hang, H. C.; Pratt, M. R. Incorporation of Unnatural Sugars for the Identification of Glycoproteins, Methods Mol. Biol. (2013), 951, 57-67. PMID: 23296524
  11. Bateman, L. A.; Zaro, B. W.; Miller, S.; Pratt, M. R. An Alkyne-Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells, J. Am. Chem. Soc. (2013), 135, 14568-14573. PMID: 23998633
  12. Bateman, L. A.; Zaro, B. W.; Chuh, K. N.; Pratt, M. R. N-Propargyloxycarbamate Monosaccharides as Metabolic Chemical Reporters of Carbohydrate Salvage Pathways and Protein Glycosylation, Chem. Comm. (2013), 49, 4328-4330. PMID: 23235740
  13. Zaro, B. W.; Bateman, L. A.; Pratt, M. R. Robust in-gel Fluorescence Detection of Mucin-type O-Linked Glycosylation, Bioorg. Med. Chem. Lett. (2011), 21, 5062-5066. PMID: 21531554
  14. Zaro, B. W.; Yang, Y. Y.; Hang, H. C.; Pratt, M. R. Chemical Reporters for Fluorescent Detection and Identification of O-GlcNAc Modified Proteins Reveal Glycosylation of the Ubiquitin Ligase NEDD4-1, Proc. Natl. Acad. Sci. USA (2011), 108, 8146-8151. PMID: 21540332
  15. Lau, H.D.; Yaegashi, J.; Zaro, B. W.; Pratt, M. R. Precise Control of Protein Concentration in Living Cells, Angew. Chem. Int. Ed. (2010), 49, 8458-8461. PMID: 20878685

Undergraduate

  1. Prakash, G. K. S.; Lau, H.; Panja, C.; Bychinskaya, I.; Ganesh, S. K.; Zaro, B. W.; Mathew, T.; Olah, G. A. Synthesis of Dihydropyrimidinones/thiopyrimidinones: Nafion-Ga, an Efficient ‘Green’ Lewis Acid Catalyst for the Biginelli Reaction, Catal. Lett. (2014) 144 (12) 2012-2020.