Optional Half-day Courses

diagram

The passage of drugs across membranes: without transport vs. by passive transport vs. by active transport.

Transporters in Drug Development

Membrane transporters are critical determinants of drug disposition, response, and toxicity. They are thus important in drug development as drug targets, as sites of clinical drug-drug interactions (DDIs) and, via genetic polymorphisms, as sources of inter-individual variation. This half-day workshop will, through lectures and interactive problem-solving, focus on transporters in the Solute Carrier and ATP Binding Cassette Superfamilies (Nature Reviews Drug Discovery 9, 215-236, 2010), including fundamentals of transport mechanisms and kinetics, in vitro methodology for studying those mechanisms, FDA decision trees for studies of transporter-mediated DDIs, and transporter polymorphisms with emphasis on methodology to predict when these might or might not be clinically significant. (Instructors: Kathy Giacomini, Les Benet and Deanna Kroetz)


diagram

A pharmacokinetic population model. Once established, models such as this can enable individualization of drug therapy for a specific patient to be more finely focused.

Introduction to Population Pharmacokinetics

Population Pharmacokinetics is the study of sources of variability in drug disposition and effects. It seeks to characterize quantitatively both the distribution of pharmacokinetic behaviors (and drug effects) throughout a population of subjects, and the separate contributions to that distribution by component subpopulations (see adjacent figure). It is an area of strong research interest, it is common practice in drug development, and it is often used in comprehensive PK/PD modeling, particularly to support simulations of future trials. This course will introduce participants to the concepts and important applications, provide an understanding of the components of population PK, and allow simple calculations that reinforce the concepts. It will also introduce participants to NONMEM® (Icon®), a widely used program for population PK. Due to time constraints, the latter aspect will be strictly didactic and NOT hands-on. (Instructor: Nancy Sambol)


Logistics for these optional courses

These courses will be held on the afternoon of February 16, 2017 immediately after the Pharmacokinetics for Pharmaceutical Scientists course. It is not possible to register for both the Transporters and the Population-PK courses together because they occur simultaneously with one another. The registration fee for either is $600 and includes also the syllabus and coffee during an afternoon break. It does not include other meals or accommodations. Enrollment is limited and no on-site registration is available. In the case of cancellations received in writing on or before January 15, 2018 the fee (less, as administrative expenses, $100 per cancelled enrollee) will be returned. There will be no refund on cancellations made after that date.

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