We use experimental and computational methods to expand our understanding of the function of mutant kinases with the overall goal of improving targeted kinase therapies in cancer and other diseases.

We are looking for a lab manager! If you are interested, please apply to this UCSF job posting.

Models comparing the P-loop conformation of KIT D816V/T670I to the P-loop of KIT D816V and the double mutants, D816V/V654A, D816V/N655K, and D816V/D677N. The pocket where the fluorophenyl moiety of avapritinib binds
Models comparing the P-loop conformation of KIT D816V/T670I (red) to the P-loop of KIT D816V (green) and the double mutants, D816V/V654A (orange), D816V/N655K (teal), and D816V/D677N (magenta). The pocket where the fluorophenyl moiety of avapritinib binds in the docked model is shown as a purple circle. From our 2019 Cancer Research paper.