We use experimental methods to expand our understanding of the function of mutant kinases with the overall goal of improving targeted kinase therapies in cancer and other diseases.
Models comparing the P-loop conformation of KIT D816V/T670I (red) to the P-loop of KIT D816V (green) and the double mutants, D816V/V654A (orange), D816V/N655K (teal), and D816V/D677N (magenta). The pocket where the fluorophenyl moiety of avapritinib binds in the docked model is shown as a purple circle. From our 2019 Cancer Research paper.
Winger Lab Welcome Lunch! From Left: Beth Apsel Winger, Lisa Pulianmackal, Emma Gunderson, Trang Dao-Pick
