People
Principal investigator
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Photo |
Who |
Research interests |
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Leslie Benet, PhD |
Drug development and regulatory sciences, pharmacokinetics, pharmacodynamics, pharmacogenomics, drug transporters, drug metabolism, drug-drug interactions, biopharmaceutics, drug delivery, enzymes and transporters, Biopharmaceutics Classification System (BCS), Biopharmaceutics Drug Disposition Classification System (BDDCS) |
Specialists
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Photo |
Who |
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Hideaki Okochi, PhD
Assistant Professional Researcher; Director, UCSF-Hair Analytical Lab (HAL)
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Alan R. Wolfe |
Graduate students
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Photo |
Who |
Research interests |
|---|---|---|
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Christine Bowman |
Improvements for the In Vitro to In Vivo Extrapolation of Hepatic Clearance Hypothesis: that considering a transporter-induced plasma protein binding shift as well as other physicochemical parameters will lead to more accurate predictions of intracellular unbound drug concentrations and IVIVE of hepatic clearance |
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Rosa Chan |
Evaluating the application of the BDDCS to assess the risk of skin and liver toxicity potential in small molecules using in vitro and human clinical data |
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Shufang Liu |
Rifampin may induce and/or inhibit hepatic uptake and efflux transporters when administered in different dosing regimens. In vivo and ex vivo studies are run to observe effects of oral doses of rifampin on intestinal transporters in the absorption of BDDCS class III drugs. |
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Jasleen Sodhi |
Drug Discovery: Volume in Predicting Distribution |
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Hsin-Fang Wu |
Two arm, randomized, cross-over clinical trials were designed and conducted in Taiwan and the US to investigate the basic mechanism of drug transporters and genetic polymorphism on the statin pharmacokinetics between Asians and Caucasians. |
Staff
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Photo |
Who |
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Frances Peterson |