Research laboratory of Pamela M. England, PhD
Chemical Biology and Drug Development Laboratory


  1. Chambers, J. J.; Gouda, H.; Young, D. M.; Kuntz, I.; England, P. M. J. Am. Chem Soc. 2004, 126, 13886-7. Photochemically knocking out glutamate receptors in vivo. PMID: 15506725. Note: This article was highlighted in Nat. Methods 2004, 1, 185.
  2. Chen, X.; Ye, H.; Kuruvilla, R.; Ramanan, N.; Scangos, K. W.; Zhang, C.; Johnson, N. M.; England, P. M.; Shokat, K. M.; Ginty, D. D. Neuron 2005, 46, 13-21. A chemical-genetic approach to studying neurotrophin signaling. PMID: 15820690
  3. Adesnik, H.; Nicoll, R. A.; England, P. M. Neuron 2006, 48, 977-85. Photoinactivation of native AMPA receptors reveals their real-time trafficking. PMID: 16364901. Note: This article was featured on the cover of Neuron
  4. Nilsen, A. and England, P. M. J. Am. Chem Soc. 2007, 129, 4902-3. A subtype-selective, use-dependent inhibitor of native AMPA receptors. PMID: 17391037. Note: This publication was highlighted in C&E News, 2007, April 12. Wasp Toxin Analog Expected to Clarify Role of Neuronal Receptors.
  5. Cruz, L.; Estebanez-Perpina, E.; Pfaff, S.; Borngraeber, S.; Bao, N.; Fletterick, R. J.; England, P. M. J. Med. Chem. 2008, 25, 5856-60. 6-azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) Forms an Irreversible Bond to the Active Site of the GluR2 AMPA Receptor. PMCID: PMC2945402
  6. Kaneko, M.; Hanover, J. L.; England, P. M.; Stryker, M. P. Nat. Neurosci. 2008, 4, 497-504. TrkB kinase is required for the recovery, but not loss, of cortical responses following monocular deprivation. PMCID: PMC2413329
  7. Wang, X.; Ratnam, J.; Zou, B.; England, P. M.; Basbaum, A. I. J. Neurosci 2009, 29, 5508-15. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. PMCID: PMC2720992
  8. Argilli, E.; Sibley, D. R.; Malenka, R. C.; England, P. M.; Bonci, A. J. Neurosci. 2009, 28, 9092-100. Mechanism and time-course of cocaine-induced LTP in the VTA. PMCID: PMC2586328
  9. Fleming, J. J. and England, P. M. Bioorg. Med. Chem. 2010, 18, 1381-7. Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. PMID: 20096591
  10. Fleming, J. J. and England, P. M. Nat. Chem. Biol. 2010, 6, 89-97. AMPA receptors and synaptic plasticity: a chemist’s perspective. PMID: 20081822
  11. England, P. M. Bridging the gaps between synapses, circuits, and behavior. Chem Biol 2010, 17, 607-15. PMID: 20609410.
  12. Aungst, S.; England, P.M.; Thompson, S.M. J. Neurophysiology 2013 109(3), 813-24. Critical role of trkB receptors in reactive axonal sprouting and hyperexcitability after traumatic axonal injury. PMCID: PMC3567381
  13. England PM. Developing a photoreactive antagonist. Methods Mol Biol. 2013 995, 121-9. PMID: 23494376.
  14. Harvey JH, Long DH, England PM, Whistler JL. ACS Med Chem Lett. 2012 3(8), 640-644. Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. PMCID: PMC3622216.
  15. England PM. Developing a photoreactive antagonist. Methods Mol Biol. 2013, 995, 121-9. PMID: 23494376