Our Research in the News

Detailed Structure Illuminates Brain-enhancing Drug’s Action:
It was great fun to collaborate again with members of the Walter and Frost labs in defining the molecular mechanism of ISRIB. Remarkable molecule and pharmacology.

Koda-Kimble Seed Award Fuels Eight Original Research Projects:
Cliff is awarded a seed grant for his proposal to synthesize water-soluble vitamin analogs as screening compounds for the SMDC.

Finding a New Target to Treat Old Pains:
Adam and Dan Minor are awarded a Trailblazer Award.

Zebrafish-to-Patient Approach Speeds Search for Childhood Epilepsy Treatments:
Priya’s work on clemilogs in collaboration with Aliesha Griffin in Scott Baraban’s lab is described in a UCSF feature article.

New Targeted Chemotherapy Technology Proves Effective in Mice:
Ben’s paper on ferrous iron targeted drug delivery in mouse xenograft models is described in a UCSF feature article.

Slowing Prions with Small Molecules:
C&EN feature article about antiprion compounds includes a discussion of IND24, first synthesized by Alejandra in our lab.

Drugs Designed to Target Specific Forms of Iron Might Become Disease Fighters:
PNAS blogs about Sumit and Edgar’s paper describing ferrous iron dependent drug delivery in mouse malaria models.

Prions May Develop Drug Resistance: The Implications for Mad Cow, Alzheimer’s and Parkinson’s:
Scientific American blogs about prion diseases and the small molecules IND24 and IND81, first synthesized in our lab.

Chemical Biology: Closing in on a new Treatment for Sleeping Sickness:
Jon and Mari’s paper on hypothemycin is featured in an eLife commentary.

Cell Biology: Less Translational Control, More Memory:
Paper describing ISRIB discovery and initial SAR is written up on eLife website.

Breaking Down the Barrier:
Alejandra’s paper describing 2-aminothiazole antiprion small molecules is covered in The Economist.