The Small Molecule Discovery Center (SMDC) collaborates with academics, government labs, and biotechnology and pharmaceutical companies to develop unique chemical probes and drug leads that address unmet medical needs. Image credits: Elisabeth …
About The Small Molecule Discovery Center (SMDC) collaborates with academics, government labs, and pharmaceutical companies to develop unique chemical probes and drug leads that address unmet medical needs. The SMDC is also a core facility in the UCSF …
People Current members Photo Who Research interests Michelle Arkin, PhD , Executive Director Professor, Department of Pharmaceutical Chemistry [email protected] chemical biology, protein-protein interactions, screening, cancer, neurodegenerative …
Facilities & Instrumentation The SMDC has the instrumentation and automation and robotics to perform biochemical (fluorescence, absorbance, luminescence, polarization), biophysical (surface plasmon resonance (SPR), differential scanning fluorimetry (DSF), …
Contact Us The Small Molecule Discovery Center (SMDC) occupies custom-built laboratory space on the fifth floor of Byers Hall at UCSF’s Mission Bay campus. For help with Contact New projects Charles Hart iLab Jeff Neitz HiTS Amanda Paulson Instrumentation …
High-throughput Screening Steps 1. Consultation Potential users are invited to discuss a screening idea with any member of the SMDC team. Options around types of compounds (e.g. non-covalent vs. covalent, diversity vs. target class-focused) are discussed …
Assay Development Time ~3–6 months Process overview You submit an application to us. You develop a primary screen amenable to automation, with a secondary assay in place. You attempt miniaturization to 384 well format if the current assay is run in 96 …
Capabilities and Services The majority of active SMDC projects fall into the drug discovery stages between Target Validation and Hits-to-Leads. On this page Hit identification (Screening) High-throughput screening (HTS) Compound libraries Fragment …
How to Reserve Instruments and Register for SMDC Use All reservations for Small Molecule Discovery Center (SMDC) instrumentation, services, and training is done via iLab . Reserve equipment by logging in to UCSF MyAccess and finding iLab. Need to …