Experts in identifying promising drug candidates
Facilities & Instrumentation
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Facility
The SMDC maintains a suite of modern robotic instrumentation that permits high-throughput biochemical and cell-based screening of our compound collections. Labs are also fully equipped for biochemistry, cell biology, and medicinal chemistry. To include SMDC facilities in NIH grants, see:
Facilities (Microsoft Word document, 1 page, 24 KB)- Major Equipment (Microsoft Word document, 2 pages, 222 KB)
High-throughput screening (HTS) instrumentation
Our HTS instrumentation is designed for 384-well formats, and most instruments are amenable to 1536-well format.
A robotic arm (1) links instrumentation for HTS automation. Instruments include Beckman Coulter barcode Print and Apply (2), BioTek EL406 and Multidrop (3, 4, 5), plate sealer (6), Cytomat plate hotel (7) Cytomat (8) and LiCONiC (9) incubated plate hotels, PerkinElmer EnVision Xcite (10), Beckman Coulter Biomek FXP liquid handler (11), and GE Healthcare Life Sciences IN Cell Analyzer 2500 LED (12).
Modular/walk-up instrumentation
We also have additional modular instrumentation for walk-up use in assay development and compound-validation experiments:
|
Instrument |
Purpose |
|---|---|
|
FlexStation 3 multimode microplate reader |
assay development and validation |
|
Biotek EL406 plate washer/dispenser |
reagent dispensing, IF, ELISA |
|
Biacore 4000 high-throughput surface plasmon resonance (SPR) instrument |
fragment-based discovery, protein-protein interactions, hit validation |
|
Xevo TQ-XS mass spectrometer |
protein characterization, disulfide trapping/tethering |
FlexStation 3
Biotek EL406
Biacore 4000
Xevo TQ-XS