Craik Lab Overview
We explore the roles and mechanisms of enzymes, receptors, and membrane proteins in complex biological processes using a vast, cross-disciplinary toolset, and we develop technologies to facilitate these studies.
We are looking to expand the lab! If you are a graduate student, postdoc, or technician interested in the Craik Lab, check out some of our recent papers below and send us an email.
- High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions
- A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy
- Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine
- In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET
- A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells
- Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes
- Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer