Research laboratory of Charles S. Craik, PhD






Charles S. Craik, PhD
Principal Investigator
[email protected]

My research focuses on structure-function analysis of proteases and their inhibitors. In my lab we use a combination of genetic, biochemical, and biophysical methods, with particular emphasis on identifying the roles and regulating the activity of proteases associated with infectious diseases, cancer, and development.


Markus-Frederik Bohn
[email protected]

I performed my PhD research at UMass Medical School on structure and biochemistry of APOBEC3 enzymes in the lab of Celia Schiffer. Thematically, I am interested in identifying novel therapeutic targets for antiviral strategies at the host-pathogen interface. Methodologically, I work at the interface between structural biology and data analytics, establishing new models for structure-function relationships of enzymatic activity. With my research I hope to elevate molecules that serve analytical, diagnostic, and therapeutic purposes to the next level of precision-engineered tools.


Efrat Harel
[email protected]

I received my BSc in molecular biochemistry (2006, Technion Israel Institute of Technology) and PhD in pharmaceutical sciences (2013, The Hebrew University of Jerusalem) in the labs of Abraham Rubinstein and Boaz Tirosh. For my graduate research, I identified and targeted biomarkers in inflamed gut epithelial tissue with liposomal drug delivery systems. I am currently focusing on utilizing anti-urokinase plasminogen activator receptor (uPAR) antagonist antibodies in addition to developing new anti-uPAR constructs.


Kaitlin Hulce
[email protected]

I received my BS in chemistry and biology from Brandeis University. While there, I worked with Dr. Jason Pontrelloon the synthesis of polymeric glutamine displays to mediate huntingtin protein aggregation and study its role in Huntington’s disease progression. I later worked with Dr. Lizbeth Hedstrom on inhibitor-mediated protein degradation, specifically designing an arginine-linked methotrexate analogue to target dihydrofolate reductase for degradation. I am currently a PhD candidate, working in the Craik Lab to develop Cysteine-targeted inhibitors of herpes virus proteases. My interests are in studying the enzymology and structure-function of this dynamic class of enzymes, as well as in rational inhibitor design to disrupt the herpes viral lifecycle.


Sam Ivry
[email protected]

I received my BS in chemical engineering from the University of California, Santa Barbara in 2012. Following graduation, I remained in Santa Barbara where I worked with Patrick Daugherty designing protease-activated antibodies for breast cancer treatment. In the Craik Lab, I am interested in applying unbiased activity-based approaches to identify proteases involved in malignancy. My initial work has focused on using our recently developed MSP-MS assay to stratify pancreatic cysts by their potential for malignant transformation. Outside of lab, I enjoy surfing the breaks along the San Francisco Peninsula and spending time with my family in the East Bay.

Luiz Laurenco

André Luiz Laurenço
[email protected]

I received my BS in development biosciences and my Msc in pathology from the Fluminense Federal University (Rio de Janeiro, Brazil). During my PhD I focused on the development of Restricted-Interaction Peptides (RIPs) for the non-invasive imaging of threatening blood clots in vivo through near-infrared (NIR) fluorescence and positron-emission tomography (PET). My research interests lie in the understanding of disease-associated proteolysis, particularly in cardiovascular diseases and cancer, to proper optimize our RIP technology toward clinical translation.


Matt Ravalin
[email protected]

My research interests center on the interface of cellular proteolysis and proteostasis. In particular, I am interested in understanding the emergent properties of products of protease activity and how these neo-epitopes interact with cellular proteostasis networks. I am using global and candidate-based approaches to characterize nodes at which proteolysis and proteostasis intersect, and I am exploring this interplay in the context of neurodegenerative disease. Prior to coming to UCSF to begin my doctoral work, I spent five years working in industrial drug discovery in San Diego after receiving by BS from UC San Diego. I try to spend as much of my free time as possible fishing, hiking, and generally enjoying the outdoors.






JoAnne Williams
[email protected]


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