1. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates

    Journal of the American Chemical Society

    Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB

  2. Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients


    Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS

  3. Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity

    Biochimica et biophysica acta. Proteins and proteomics

    Sevillano N, Bohn MF, Zimanyi M, Chen Y, Petzold C, Gupta S, Ralston CY, Craik CS

  4. An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans


    Lohse MB, Brenes LR, Ziv N, Winter MB, Craik CS, Johnson AD

  5. An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers

    Molecular imaging and biology

    Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ

  6. Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction

    Journal of the American Chemical Society

    Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C

  7. Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization

    bioRxiv : the preprint server for biology

    Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, Hanson BJ, Rosa-Calatrava M, Manglik A, Cheng Y, Craik CS, Wang CI

  8. Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms

    Frontiers in microbiology

    Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ

  9. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing


    Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ

  10. Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes

    Scientific reports

    Vasiljeva O, Menendez E, Nguyen M, Craik CS, Michael Kavanaugh W

  11. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

    bioRxiv : the preprint server for biology

    Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ

  12. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin

    Frontiers in cellular and infection microbiology

    Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L

  13. Further Evidence that the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes


    Harel E, Shoji J, Abraham V, Miller L, Laszik ZG, King A, Dobi D, Szabo G, Hann B, Sarwal MM, Craik CS, Vincenti F

  14. The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts

    Biological chemistry

    Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS

  15. End-Binding E3 Ubiquitin Ligases Enable Protease Signaling

    ACS chemical biology

    Ravalin M, Basu K, Gestwicki JE, Craik CS

  16. Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer

    Antibodies (Basel, Switzerland)

    Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS

  17. KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment

    The American journal of pathology

    Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ

  18. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases

    Nature chemical biology

    Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE

  19. Why recombinant antibodies - benefits and applications

    Current opinion in biotechnology

    Basu K, Green EM, Cheng Y, Craik CS

  20. Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation

    Clinical transplantation

    Harel E, Shoji J, Abraham V, Miller L, Laszik Z, Thurison T, King A, Olshen A, Leung J, Szabo G, Hann B, Høyer-Hansen G, Craik CS, Vincenti F

  21. Progranulin Stimulates the in vitro Maturation of pro-Cathepsin D at Acidic pH

    Journal of molecular biology

    Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW

  22. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology

    Journal of medicinal chemistry

    Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant S, Helander J, Klefström J, Craik CS, Janetka JW

  23. Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

    PloS one

    Schneidman-Duhovny D, Khuri N, Dong GQ, Winter MB, Shifrut E, Friedman N, Craik CS, Pratt KP, Paz P, Aswad F, Sali A

  24. Discovery and characterization of a thioesterase-specific monoclonal antibody that recognizes the 6-deoxyerythronolide B synthase


    Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C

  25. A preclinical assessment of 89Zr-atezolizumab identifies a requirement for carrier added formulations not observed with 89Zr-C4

    Bioconjugate chemistry

    Moroz A, Lee CY, Wang YH, Hsiao JC, Sevillano N, Truillet C, Craik CS, Fong L, Wang CI, Evans MJ

  26. Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin

    Scientific reports

    Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P

  27. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module

    Journal of the American Chemical Society

    Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C

  28. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

    PLoS neglected tropical diseases

    Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M

  29. Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

    Frontiers in molecular biosciences

    Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF

  30. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

    PLoS pathogens

    Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD

  31. Cryo-EM structures of the TMEM16A calcium-activated chloride channel


    Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY

  32. Global substrate specificity profiling of post-translational modifying enzymes

    Protein science : a publication of the Protein Society

    Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS

  33. Immunoproteasome functions explained by divergence in cleavage specificity and regulation


    Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS

  34. Imaging PD-L1 Expression with ImmunoPET

    Bioconjugate chemistry

    Truillet C, Oh HLJ, Yeo SP, Lee CY, Huynh LT, Wei J, Parker MFL, Blakely C, Sevillano N, Wang YH, Shen YS, Olivas V, Jami KM, Moroz A, Jego B, Jaumain E, Fong L, Craik CS, Chang AJ, Bivona TG, Wang CI, Evans MJ

  35. Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2

    Journal of molecular biology

    Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ

  36. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases

    Journal of the American Chemical Society

    Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS

  37. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates

    Thrombosis and haemostasis

    Kara E, Manna D, Løset GÅ, Schneider EL, Craik CS, Kanse S

  38. Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms

    Arthritis & rheumatology (Hoboken, N.J.)

    Wilkinson DJ, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD

  39. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria

    ACS chemical biology

    Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW

  40. Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts

    Clinical cancer research : an official journal of the American Association for Cancer Research

    Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS

  41. Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents

    European journal of medicinal chemistry

    Lourenço AL, Salvador RRS, Silva LA, Saito MS, Mello JFR, Cabral LM, Rodrigues CR, Vera MAF, Muri EMF, de Souza AMT, Craik CS, Dias LRS, Castro HC, Sathler PC

  42. Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs

    Analytical chemistry

    Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS

  43. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases


    Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA

  44. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

    PLoS pathogens

    Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS

  45. Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23

    BMC bioinformatics

    Barkan DT, Cheng XL, Celino H, Tran TT, Bhandari A, Craik CS, Sali A, Smythe ML

  46. Global Identification of Biofilm-Specific Proteolysis in Candida albicans


    Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ

  47. Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors

    Biological chemistry

    O'Donoghue AJ, Ivry SL, Chaudhury C, Hostetter DR, Hanahan D, Craik CS

  48. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria

    PLoS neglected tropical diseases

    Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH

  49. Label-Free Electrical Detection of Enzymatic Reactions in Nanochannels

    ACS nano

    Duan C, Alibakhshi MA, Kim DK, Brown CM, Craik CS, Majumdar A

  50. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis

    ACS infectious diseases

    Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M

  51. Intracellular Action of a Secreted Peptide Required for Fungal Virulence

    Cell host & microbe

    Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik CS, Madhani HD

  52. Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling


    Le Gall SM, Szabo R, Lee M, Kirchhofer D, Craik CS, Bugge TH, Camerer E

  53. Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase

    ACS chemical biology

    Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ

  54. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

    Proceedings of the National Academy of Sciences of the United States of America

    Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA

  55. Structure- and function-based design of Plasmodium-selective proteasome inhibitors


    Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M

  56. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease


    Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS

  57. Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion

    Marine biotechnology (New York, N.Y.)

    Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F

  58. Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity


    Jones SK, Clarke SC, Craik CS, Bennett RJ

  59. In vivo imaging of protease activity by Probody therapeutic activation


    Wong KR, Menendez E, Craik CS, Kavanaugh WM, Vasiljeva O

  60. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography

    Nature communications

    Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS

  61. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles


    Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ

  62. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome

    Proceedings of the National Academy of Sciences of the United States of America

    O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ

  63. Ecotin: Exploring a feasible antithrombotic profile

    International journal of biological macromolecules

    Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB

  64. Imaging active urokinase plasminogen activator in prostate cancer

    Cancer research

    LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF

  65. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

    The Biochemical journal

    Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D

  66. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter


    Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y

  67. Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity

    The Journal of biological chemistry

    Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P

  68. Cullin E3 ligases and their rewiring by viral factors


    Mahon C, Krogan NJ, Craik CS, Pick E

  69. Current and potential treatments for ubiquitous but neglected herpesvirus infections

    Chemical reviews

    Gable JE, Acker TM, Craik CS

  70. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia

    ACS nano

    Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS

  71. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis

    Cancer discovery

    Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, Simon JA, Bedalov A, Nelson PS

  72. Broad-spectrum allosteric inhibition of herpesvirus proteases


    Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS

  73. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts

    The Journal of biological chemistry

    Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA

  74. Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance


    LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF

  75. Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology

    Methods in enzymology

    Tajon C, Jun YW, Craik CS

  76. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction

    Cancer discovery

    Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP

  77. Elastin degradation by cathepsin V requires two exosites

    The Journal of biological chemistry

    Du X, Chen NL, Wong A, Craik CS, Brömme D

  78. Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase

    PloS one

    O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW

  79. Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica

    PLoS neglected tropical diseases

    Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF

  80. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis

    The Journal of biological chemistry

    Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S

  81. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors

    The Journal of biological chemistry

    Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH

  82. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer

    Cancer research

    LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS

  83. Imaging a functional tumorigenic biomarker in the transformed epithelium

    Proceedings of the National Academy of Sciences of the United States of America

    LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS

  84. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy


    Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS

  85. Global identification of peptidase specificity by multiplex substrate profiling

    Nature methods

    O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS

  86. Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells

    American journal of physiology. Lung cellular and molecular physiology

    Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH

  87. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1)

    The Journal of biological chemistry

    Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P

  88. Fabs enable single particle cryoEM studies of small proteins

    Structure (London, England : 1993)

    Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y

  89. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni

    PLoS neglected tropical diseases

    Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH

  90. Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference


    Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV, Smooker PM

  91. A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor

    Methods in molecular biology (Clifton, N.J.)

    Craik CS, Shahian T

  92. Global landscape of HIV-human protein complexes


    Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ

  93. Vif hijacks CBF-ß to degrade APOBEC3G and promote HIV-1 infection


    Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, Sali A, Craik CS, Harris RS, Gross JD, Krogan NJ

  94. A reverse binding motif that contributes to specific protease inhibition by antibodies

    Journal of molecular biology

    Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS

  95. Rapid identification of recombinant Fabs that bind to membrane proteins

    Methods (San Diego, Calif.)

    Kim J, Stroud RM, Craik CS

  96. Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis

    The Prostate

    Ray M, Hostetter DR, Loeb CR, Simko J, Craik CS

  97. Human and mouse granzyme M display divergent and species-specific substrate specificities

    The Biochemical journal

    de Poot SA, Westgeest M, Hostetter DR, Van Damme P, Plasman K, Demeyer K, Broekhuizen R, Gevaert K, Craik CS, Bovenschen N

  98. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay

    Antiviral research

    Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G

  99. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus

    International journal for parasitology

    Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P

  100. GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data

    BMC bioinformatics

    Fahey ME, Bennett MJ, Mahon C, Jäger S, Pache L, Kumar D, Shapiro A, Rao K, Chanda SK, Craik CS, Frankel AD, Krogan NJ

  101. Enzyme inhibition by allosteric capture of an inactive conformation

    Journal of molecular biology

    Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS

  102. Proteases as therapeutics

    The Biochemical journal

    Craik CS, Page MJ, Madison EL

  103. Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors

    Chemistry & biology

    Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS

  104. Mechanisms of macromolecular protease inhibitors

    Chembiochem : a European journal of chemical biology

    Farady CJ, Craik CS

  105. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion

    The Journal of biological chemistry

    Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH

  106. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4

    PLoS neglected tropical diseases

    Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y

  107. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution

    Journal of immunology (Baltimore, Md. : 1950)

    Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH

  108. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides

    Parasites & vectors

    Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S

  109. Prediction of protease substrates using sequence and structure features

    Bioinformatics (Oxford, England)

    Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A

  110. Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration

    The Journal of biological chemistry

    Duriseti S, Goetz DH, Hostetter DR, LeBeau AM, Wei Y, Craik CS

  111. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target

    The Journal of biological chemistry

    He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL

  112. Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation

    Biological chemistry

    Stoop AA, Joshi RV, Eggers CT, Craik CS

  113. Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer

    Biological chemistry

    LeBeau AM, Kostova M, Craik CS, Denmeade SR

  114. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence

    Cell host & microbe

    Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS

  115. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors

    ACS nano

    Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X

  116. Tumor detection by imaging proteolytic activity

    Cancer research

    Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS

  117. Local protease signaling contributes to neural tube closure in the mouse embryo

    Developmental cell

    Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR

  118. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level

    Proceedings of the National Academy of Sciences of the United States of America

    Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP

  119. Engineering ecotin for identifying proteins with a trypsin fold

    Applied biochemistry and biotechnology

    Sathler PC, Craik CS, Takeuchi T, Zingali RB, Castro HC

  120. Inhibition of a viral enzyme by a small-molecule dimer disruptor

    Nature chemical biology

    Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS

  121. Vinyl sulfones as antiparasitic agents and a structural basis for drug design

    The Journal of biological chemistry

    Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS

  122. Two approaches to discovering and developing new drugs for Chagas disease

    Memorias do Instituto Oswaldo Cruz

    McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS

  123. Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii

    Microbiology (Reading, England)

    Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG

  124. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni

    PLoS neglected tropical diseases

    Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR

  125. Improving the species cross-reactivity of an antibody using computational design

    Bioorganic & medicinal chemistry letters

    Farady CJ, Sellers BD, Jacobson MP, Craik CS

  126. Substrate specificity of transthyretin: identification of natural substrates in the nervous system

    The Biochemical journal

    Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM

  127. Trapping moving targets with small molecules

    Science (New York, N.Y.)

    Lee GM, Craik CS

  128. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3

    PloS one

    Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ

  129. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution

    The Journal of biological chemistry

    Lilla JN, Joshi RV, Craik CS, Werb Z

  130. Positional scanning synthetic combinatorial libraries for substrate profiling

    Methods in molecular biology (Clifton, N.J.)

    Schneider EL, Craik CS

  131. Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array

    Nano letters

    Raorane DA, Lim MD, Chen FF, Craik CS, Majumdar A

  132. A parasite cysteine protease is key to host protein degradation and iron acquisition

    The Journal of biological chemistry

    O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH

  133. Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii

    The Journal of biological chemistry

    O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG

  134. The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti

    International journal for parasitology

    Dolecková K, Kasný M, Mikes L, Cartwright J, Jedelský P, Schneider EL, Dvorák J, Mountford AP, Craik CS, Horák P

  135. Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis

    Archives of biochemistry and biophysics

    Lucas JJ, Hayes GR, Kalsi HK, Gilbert RO, Choe Y, Craik CS, Singh BN

  136. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7

    Biological chemistry

    Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P

  137. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition

    Journal of molecular biology

    Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS

  138. Identification of the major cysteine protease of Giardia and its role in encystation

    The Journal of biological chemistry

    DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M

  139. Using specificity to strategically target proteases

    Bioorganic & medicinal chemistry

    Lim MD, Craik CS

  140. MT-SP1 proteolysis and regulation of cell-microenvironment interactions

    Frontiers in bioscience : a journal and virtual library

    Darragh MR, Bhatt AS, Craik CS

  141. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica

    The Journal of biological chemistry

    Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP

  142. Substrate modulation of enzyme activity in the herpesvirus protease family

    Journal of molecular biology

    Lazic A, Goetz DH, Nomura AM, Marnett AB, Craik CS

  143. Hip is a pro-survival substrate of granzyme B

    The Journal of biological chemistry

    Hostetter DR, Loeb CR, Chu F, Craik CS

  144. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus


    Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS

  145. Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity

    Journal of nanoscience and nanotechnology

    Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP

  146. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model

    Eukaryotic cell

    Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL

  147. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1)

    Journal of molecular biology

    Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS

  148. Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway

    Proceedings of the National Academy of Sciences of the United States of America

    Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS

  149. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus

    International journal for parasitology

    Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P

  150. Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces

    Journal of the American Chemical Society

    Chu F, Mahrus S, Craik CS, Burlingame AL

  151. Expression and characterization of constitutively active human caspase-14

    Biochemical and biophysical research communications

    Park K, Kuechle MK, Choe Y, Craik CS, Lawrence OT, Presland RB

  152. Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis

    The Journal of biological chemistry

    Loeb CR, Harris JL, Craik CS

  153. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice

    The EMBO journal

    Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J

  154. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences

    The Journal of biological chemistry

    Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P

  155. Ecotin modulates thrombin activity through exosite-2 interactions

    The international journal of biochemistry & cell biology

    Castro HC, Monteiro RQ, Assafim M, Loureiro NI, Craik C, Zingali RB

  156. Conversion of trypsin to a functional threonine protease

    Protein science : a publication of the Protein Society

    Baird TT, Wright WD, Craik CS

  157. One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease


    Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS

  158. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

    The Journal of biological chemistry

    Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS

  159. Induced structure of a helical switch as a mechanism to regulate enzymatic activity

    Nature structural & molecular biology

    Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS

  160. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

    The Biochemical journal

    Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ

  161. Adhesion signaling by a novel mitotic substrate of src kinases


    Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM

  162. Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells

    Chemistry & biology

    Mahrus S, Craik CS

  163. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease

    Bioorganic & medicinal chemistry

    Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS

  164. Papa's got a brand new tag: advances in identification of proteases and their substrates

    Trends in biotechnology

    Marnett AB, Craik CS

  165. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries

    The Prostate

    Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS

  166. Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B

    The Journal of biological chemistry

    Mahrus S, Kisiel W, Craik CS

  167. Optimization of 13C direct detection NMR methods

    Journal of biomolecular NMR

    Shimba N, Kovacs H, Stern AS, Nomura AM, Shimada I, Hoch JC, Craik CS, Dötsch V

  168. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms

    The Journal of biological chemistry

    Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A

  169. Methyl groups as probes for proteins and complexes in in-cell NMR experiments

    Journal of the American Chemical Society

    Serber Z, Straub W, Corsini L, Nomura AM, Shimba N, Craik CS, Ortiz de Montellano P, Dötsch V

  170. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity

    The Journal of biological chemistry

    Ruggles SW, Fletterick RJ, Craik CS

  171. Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor

    Proceedings of the National Academy of Sciences of the United States of America

    Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS

  172. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase

    The Biochemical journal

    Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS

  173. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax

    The Biochemical journal

    Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ

  174. Untitled Publication

    Brachyurins. Tsu, C., and Craik, C.S. Handbook of Proteolytic Enzymes

  175. Untitled Publication

    Shimba, N. Nomura, A.M., Marnett, A.B. and Craik, C.S. Herpesvirus Protease Inhibition by Dimer Disruption. J. Virol

  176. Engineering of a macromolecular scaffold to develop specific protease inhibitors

    Nature biotechnology

    Stoop AA, Craik CS

  177. Quantitative identification of the protonation state of histidines in vitro and in vivo


    Shimba N, Serber Z, Ledwidge R, Miller SM, Craik CS, Dötsch V

  178. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity

    Nature structural biology

    Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS

  179. Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site

    The Journal of biological chemistry

    Raymond WW, Ruggles SW, Craik CS, Caughey GH

  180. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII

    The Biochemical journal

    Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA

  181. The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors

    Proceedings of the National Academy of Sciences of the United States of America

    Mackewicz CE, Craik CS, Levy JA

  182. Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction

    Journal of the American Chemical Society

    Shimba N, Stern AS, Craik CS, Hoch JC, Dötsch V

  183. Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies


    Sun J, Pons J, Craik CS

  184. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells

    Biological chemistry

    Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS

  185. Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence

    Bioorganic & medicinal chemistry letters

    Barrios AM, Craik CS

  186. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites

    The Biochemical journal

    Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ

  187. Design and synthesis of novel inhibitors of gelatinase B

    Bioorganic & medicinal chemistry letters

    Wang X, Choe Y, Craik CS, Ellman JA

  188. Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity


    Lecaille F, Choe Y, Brandt W, Li Z, Craik CS, Brömme D

  189. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes

    The Journal of biological chemistry

    Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH

  190. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries

    Molecular and biochemical parasitology

    Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH

  191. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition

    The Journal of biological chemistry

    Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS

  192. Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure


    Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM

  193. Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction


    Wang B, Brown KC, Lodder M, Craik CS, Hecht SM

  194. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore

    The Journal of organic chemistry

    Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA

  195. Conformational change coupling the dimerization and activation of KSHV protease


    Pray TR, Reiling KK, Demirjian BG, Craik CS

  196. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease

    Journal of virology

    Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS

  197. Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer

    Protein science : a publication of the Protein Society

    Person MD, Brown KC, Mahrus S, Craik CS, Burlingame AL

  198. Definition of the extended substrate specificity determinants for beta-tryptases I and II

    The Journal of biological chemistry

    Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS

  199. Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform?

    Biochimica et biophysica acta

    Castro HC, Silva DM, Craik C, Zingali RB

  200. The role of ecotin dimerization in protease inhibition

    Journal of molecular biology

    Eggers CT, Wang SX, Fletterick RJ, Craik CS

  201. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation

    Nature cell biology

    Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z

  202. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus

    Journal of virology

    Nealon K, Newcomb WW, Pray TR, Craik CS, Brown JC, Kedes DH

  203. Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements


    Reiling KK, Pray TR, Craik CS, Stroud RM

  204. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity

    Nature structural biology

    Waugh SM, Harris JL, Fletterick R, Craik CS

  205. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates

    The Journal of biological chemistry

    Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS

  206. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

    Proceedings of the National Academy of Sciences of the United States of America

    Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS

  207. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases

    Journal of molecular biology

    Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ

  208. Cathepsin G activates protease-activated receptor-4 in human platelets

    The Journal of biological chemistry

    Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR

  209. Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers

    The Journal of biological chemistry

    Rozzelle JE, Dauber DS, Todd S, Kelley R, Craik CS

  210. HIV protease as a target for retrovirus vector-mediated gene therapy

    Biochimica et biophysica acta

    Todd S, Anderson C, Jolly DJ, Craik CS

  211. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

    Nature biotechnology

    Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA

  212. Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants

    Analytical biochemistry

    Todd S, Laboissière MC, Craik CS

  213. J. Am. Chem. Soc

    Chemically Mediated Site-Specific Cleavage of Proteins

    B. Wang, M. Lodder, J. Zhou, T.T. Baird, Jr., K.C. Brown, C.S. Craik, S.M. Hecht

  214. Untitled Publication

    K.K. Reiling, T.R. Pray, C.S. Craik, R.M. Stroud. Structure: Regulation of Activity and Dimerization by Conserved Structural Elements. Biochemistry

  215. Untitled Publication

    T.T. Baird Jr., B. Wang, M. Lodder, S.M. Hecht and C.S. Craik. Generation of Active Trypsin by Chemical Cleavage. Tetrahedron Letters

  216. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

    Proceedings of the National Academy of Sciences of the United States of America

    Takeuchi T, Shuman MA, Craik CS

  217. Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease

    Journal of molecular biology

    Pray TR, Nomura AM, Pennington MW, Craik CS

  218. Definition and redesign of the extended substrate specificity of granzyme B

    The Journal of biological chemistry

    Harris JL, Peterson EP, Hudig D, Thornberry NA, Craik CS

  219. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites

    Journal of molecular biology

    Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS

  220. Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator

    Journal of molecular biology

    Yang SQ, Craik CS

  221. Determining protein-protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein


    Brown KC, Yu Z, Burlingame AL, Craik CS

  222. Domain flexibility in retroviral proteases: structural implications for drug resistant mutations


    Rose RB, Craik CS, Stroud RM

  223. Engineering enzyme specificity

    Current opinion in chemical biology

    Harris JL, Craik CS

  224. Engineering catalytically defective forms of HIV protease to modulate its activity

    Advances in experimental medicine and biology

    Craik CS, Babé LM, Dauber D, McPhee F, Rosé J, Unal A

  225. Optimization of a macromolecular inhibitor of HIV-1 protease

    Advances in experimental medicine and biology

    Dauber DS, McPhee F, Unal A, Craik CS

  226. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

    The Journal of biological chemistry

    Perona JJ, Craik CS

  227. Viral proteases: evolution of diverse structural motifs to optimize function


    Babé LM, Craik CS

  228. Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor

    Bioorganic & medicinal chemistry

    Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR

  229. The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8)

    Journal of virology

    Unal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS

  230. Structural determinants of specificity in the cysteine protease cruzain

    Protein science : a publication of the Protein Society

    Gillmor SA, Craik CS, Fletterick RJ

  231. The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease

    Bioorganic & medicinal chemistry

    Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR

  232. P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes

    Journal of immunology (Baltimore, Md. : 1950)

    Ewoldt GR, Smyth MJ, Darcy PK, Harris JL, Craik CS, Horowitz B, Woodard SL, Powers JC, Hudig D

  233. Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix


    Perona JJ, Tsu CA, Craik CS, Fletterick RJ

  234. Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1


    Tsu CA, Perona JJ, Fletterick RJ, Craik CS

  235. Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    Babé LM, Unal A, Craik CS

  236. Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity

    Pharmaceutical research

    Kågedahl M, Swaan PW, Redemann CT, Tang M, Craik CS, Szoka FC, Oie S

  237. Untitled Publication

    C.S. Craik & R.J. Fletterick. The Marriage of Protein Structure and Pharmaceutical Discovery. Biotech. & Appl. Biochem. 26

  238. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro

    The Biochemical journal

    McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS

  239. Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines

    Journal of virology

    Junker U, Escaich S, Plavec I, Baker J, McPhee F, Rose JR, Craik CS, Böhnlein E

  240. Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation

    Proceedings of the National Academy of Sciences of the United States of America

    McPhee F, Good AC, Kuntz ID, Craik CS

  241. Three-dimensional structures of HIV-1 and SIV protease product complexes


    Rose RB, Craik CS, Douglas NL, Stroud RM

  242. X-ray structures of a designed binding site in trypsin show metal-dependent geometry


    Brinen LS, Willett WS, Craik CS, Fletterick RJ

  243. Substrate recognition by recombinant serine collagenase 1 from Uca pugilator

    The Journal of biological chemistry

    Tsu CA, Craik CS

  244. Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases

    Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

    Gudmundsdóttir E, Spilliaert R, Yang Q, Craik CS, Bjarnason JB, Gudmundsdóttir A

  245. Phage display of proteases and macromolecular inhibitors

    Methods in enzymology

    Wang CI, Yang Q, Craik CS

  246. Untitled Publication

    E.E. Rutenber, F. McPhee, A.P. Kaplan, S.L. Gallion, J.C. Hogan Jr., C.S. Craik & R.M. Stroud. A New Class of HIV1 Protease Inhibitor: The Crystallographic Structure, Inhibition and Chemical Synthesis of an Aminimide Peptide Isostere. Bioorg.& Med. Chem. 4

  247. Untitled Publication

    R. Li, X. Chen, B. Gong, Z. Li, E. Davidson, G. Kurzban, R.E. Miller, E.O. Nuzman, J.H. McKerrow, R.J. Fletterick, S.A. Gillmore, C.S. Craik, I.D. Kuntz, F.E. Cohen & G.L. Kenyon. Structure-based Design of Parasitic Protease Inhibitors. Bioorg. & Med. Chem. 4

  248. Untitled Publication

    S. Halfon & C.S. Craik. Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding Loops. J. Am. Chem. Soc. 118

  249. Untitled Publication

    W.S. Willett, L.S. Brinen, R.J. Fletterick & C.S. Craik. Delocalizing Trypsin Specificity with Metal-Activation. Biochem; 35

  250. Untitled Publication

    Z. Yu, P. Caldera, F. McPhee, J. DeVoss, P.R. Jones, A. Burlingame, I. Kuntz, C.S. Craik & P.R. Ortiz de Montellano. Irreversible Inhibition of the HIV-1 Protease: Targeting Alkylating Agents to the Catalytic Aspartate Groups. J. Amer. Chem. Soc. 118

  251. Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation

    Proceedings of the National Academy of Sciences of the United States of America

    Babé LM, Rosé J, Craik CS

  252. Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs


    Liu SH, Wong ML, Craik CS, Brodsky FM

  253. Trypsin specificity increased through substrate-assisted catalysis


    Corey DR, Willett WS, Coombs GS, Craik CS

  254. Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin

    The Journal of biological chemistry

    Wang CI, Yang Q, Craik CS

  255. Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

    Journal of virology

    Rosé JR, Babé LM, Craik CS

  256. The crystal structure of cruzain: a therapeutic target for Chagas' disease

    Journal of molecular biology

    McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ

  257. Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity

    Protein engineering

    Sloane DL, Leung R, Barnett J, Craik CS, Sigal E

  258. Structural basis of substrate specificity in the serine proteases

    Protein science : a publication of the Protein Society

    Perona JJ, Craik CS

  259. Engineered metal regulation of trypsin specificity


    Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS

  260. Untitled Publication

    A.E. Eakin, J.H. McKerrow & C.S.Craik. A Cysteine Protease is a Target for the Enzyme Structure-based Design of Antiparasitic Drugs. Drug Information Journal 29

  261. Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors

    American journal of respiratory and critical care medicine

    Rosé JR, Craik CS

  262. Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation

    Antimicrobial agents and chemotherapy

    Babé LM, Craik CS

  263. Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen

    Biochimica et biophysica acta

    Guthmundsdóttir A, Oskarsson S, Eakin AE, Craik CS, Bjarnason JB

  264. The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites

    The Journal of biological chemistry

    Tsu CA, Perona JJ, Schellenberger V, Turck CW, Craik CS

  265. Can small cyclic peptides have the activity and specificity of proteolytic enzymes?

    Proceedings of the National Academy of Sciences of the United States of America

    Matthews BW, Craik CS, Neurath H

  266. In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases

    The Journal of biological chemistry

    Salto R, Babé LM, Li J, Rosé JR, Yu Z, Burlingame A, De Voss JJ, Sui Z, Ortiz de Montellano P, Craik CS

  267. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser


    Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ

  268. Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases

    Journal of medicinal chemistry

    De Voss JJ, Sui Z, DeCamp DL, Salto R, Babé LM, Craik CS, Ortiz de Montellano PR

  269. Untitled Publication

    K.L. Lee, F. McPhee, J.J. DeVoss, C.S. Craik & P. Ortiz de Montellano. Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the two Aryl Rings of Haloperidol. J. of Organic Chemistry 59

  270. A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin


    Perona JJ, Evnin LB, Craik CS

  271. Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor


    Rose RB, Rosé JR, Salto R, Craik CS, Stroud RM

  272. Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen

    European journal of biochemistry

    Gudmundsdóttir A, Gudmundsdóttir E, Oskarsson S, Bjarnason JB, Eakin AK, Craik CS

  273. Locating the catalytic water molecule in serine proteases

    Science (New York, N.Y.)

    Perona JJ, Craik CS, Fletterick RJ

  274. Trypsin display on the surface of bacteriophage


    Corey DR, Shiau AK, Yang Q, Janowski BA, Craik CS

  275. Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions

    The Journal of biological chemistry

    Rosé JR, Salto R, Craik CS

  276. Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI

    Journal of molecular biology

    Perona JJ, Tsu CA, Craik CS, Fletterick RJ

  277. Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi

    The Journal of biological chemistry

    Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS

  278. Structure of an engineered, metal-actuated switch in trypsin


    McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ

  279. J. Bio. Chem

    Structure of a Non-Peptide Inhibitor Complexed with HIV-1 Protease: Developing a Cycle of Structure-Based Drug Design

    E. Rutenber, E.B. Fauman, R.J. Keenan, S. Fong, P.S. Furth, P.R. Ortiz de Montellano, E. Meng, I.D. Kuntz, D.L. DeCamp, R. Salto, J.R. Rosé, C.S. Craik, R.M. Stroud.

  280. Synthesis

    Synthesis of Haloperidol Ethanedithioketal HIV-1 Protease Inhibitors: Magnesium Chloride Facilitated Addition of Grignard Reagents

    Z. Sui, J. DeVoss, D. DeCamp, J. Li, C.S. Craik & P.R. Ortiz de Montellano

  281. Untitled Publication

    D.L. Decamp, S.B. Kahl & C.S. Craik. Boronated Porphyrins—A New Class of HIV Proteinase Inhibitors. Intl. Antiviral News 1

  282. Untitled Publication

    J.J. Perona, C.A. Tsu, M.E. McGrath, C.S. Craik & R.J. Fletterick. Relocating a Negative Charge in the Binding Pocket of Trypsin. J. Mol. Bio. 230

  283. Untitled Publication

    T.K. Sawyer, J.F. Fisher, J.B. Hester, C.W. Smith, A.G. Tomasselli, W.G. Tarpley, P.S. Burton, J.O. Hui T.J. McQuade, R.A. Conradi, V.S. Bradford, L. Liu, J.H. Kinner, J.Tustin,D.L. Alexander, A.W. Harrison, D.E. Emmert, D.J. Staples, L.I. Maggira, Y.Z. Zhang, R.A. Poorman, BM. Dunn, C. Rao, .E. Scarborough, W.T. Lowther, C.S. Craik, D. DeCamp, J.Moon, W.H. Howe & R.L. Heinrikson. Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease (HIV-PR): Design, Enzyme Binding and Selectivity, Antiviral Efficacy and Cell Permeability Properties. Bioorg. Med. Chem. Letts 3

  284. Untitled Publication

    Z. Sui, R. Salto, C.S. Craik, P. Ortiz de Montellano. Inhibition of the HIV1 and the HIV2 Proteases by Curcumin and Curcumin Boron Complexes. Bioorg. & Med. Chem. Let. 1

  285. Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases

    Protein science : a publication of the Protein Society

    Babé LM, Rosé J, Craik CS

  286. Specific inhibition of HIV-1 protease by boronated porphyrins

    Journal of medicinal chemistry

    DeCamp DL, Babé LM, Salto R, Lucich JL, Koo MS, Kahl SB, Craik CS

  287. The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi

    The Journal of biological chemistry

    Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS

  288. Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214


    McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ

  289. Engineered metalloregulation in enzymes

    Trends in biochemical sciences

    Higaki JN, Fletterick RJ, Craik CS

  290. Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin

    Journal of bacteriology

    Erpel T, Hwang P, Craik CS, Fletterick RJ, McGrath ME

  291. Int. J. Pep. Protein Res

    HIV Protease (HIV PR) Inhibitor Structure-Activity-Selectivity and Active Site Molecular Modeling of High Affinity Leu [CH(OH)CH2] Val Modified Viral and Nonviral Substrate Analogs

    T.K. Sawyer, D.J. Staples, L. Liu, A.G. Tomasselli, J.O. Hui, K. O’Connell, H. Schostarez, J.B. Hester, J. Moon, W.J. Howe, C.W. Smith, D. L. DeCamp, C.S. Craik, B.M. Dunn,W. T. Lowther, J. Harris, R.A. Poorman, A. Wlodawer, M. Jaskolski & R.L. Heinrikson.

  292. Untitled Publication

    D.R. Corey, M.E. McGrath, J.R. Vasquez, R.J. Fletterick & C.S. Craik. An Alternate Geometry for the Catalytic Triad of Serine Proteases. J. Amer. Chem. Soc. 114

  293. A primary determinant for lipoxygenase positional specificity


    Sloane DL, Leung R, Craik CS, Sigal E

  294. Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases

    Journal of molecular biology

    Wilke ME, Higaki JN, Craik CS, Fletterick RJ

  295. Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis

    Journal of molecular biology

    Wilke ME, Higaki JN, Craik CS, Fletterick RJ

  296. The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli

    The Journal of biological chemistry

    McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS

  297. Inhibition of HIV protease activity by heterodimer formation


    Babé LM, Pichuantes S, Craik CS

  298. 1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures


    Earnest T, Fauman E, Craik CS, Stroud R

  299. A Primary Determinant for Lipoxygenase Postional Specificity. Nature 354, 149-152

    A Primary Determinant for Lipoxygenase Postional Specificity. Nature 354, 149-152

    D.L. Sloane, R. Leung, C.S. Craik & E. Sigal

  300. Adv. Exptl. Med. Bio

    Structure-based inhibition of HIV-1 protease activity and viral infectivity

    D.L. DeCamp, L.M. Babé, P. Furth, P. Ortiz de Montellano, I.D. Kuntz & C.S. Craik

  301. Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2


    Tomasselli AG, Howe WJ, Hui JO, Sawyer TK, Reardon IM, DeCamp DL, Craik CS, Heinrikson RL

  302. Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems

    Advances in prostaglandin, thromboxane, and leukotriene research

    Sloane DL, Dixon RA, Craik CS, Sigal E

  303. Structure-based inhibition of HIV-1 protease activity and viral infectivity

    Advances in experimental medicine and biology

    DeCamp DL, Babé LM, Furth P, Ortiz de Montellano P, Kuntz ID, Craik CS

  304. Time dependent heterodimer formation leads to inhibition of HIV protease activity

    Advances in experimental medicine and biology

    Babé LM, Craik CS

  305. Untitled Publication

    C.S.Craik. Modus Operandi. Nature

  306. Regulation of serine protease activity by an engineered metal switch


    Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS

  307. Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast

    Biochemical and biophysical research communications

    Bathurst IC, Moen LK, Lujan MA, Gibson HL, Feucht PH, Pichuantes S, Craik CS, Santi DV, Barr PJ

  308. Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal

    Proceedings of the National Academy of Sciences of the United States of America

    Hall MN, Craik C, Hiraoka Y

  309. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease

    Proceedings of the National Academy of Sciences of the United States of America

    DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babé LM, Craik CS

  310. Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro

    The Journal of biological chemistry

    Pichuantes S, Babé LM, Barr PJ, DeCamp DL, Craik CS

  311. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family

    Proceedings of the National Academy of Sciences of the United States of America

    Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH

  312. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter

    American journal of human genetics

    Stewart EA, Craik CS, Hake L, Bowcock AM

  313. Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related

    The Journal of biological chemistry

    Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS

  314. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites

    Molecular and biochemical parasitology

    Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH

  315. The expression of active human reticulocyte 15-lipoxygenase in bacteria

    Biomedica biochimica acta

    Sloane DL, Craik CS, Sigal E

  316. Untitled Publication

    L. Evnin, J. Vasquez & C.S. Craik. Proc. Substrate Specificity of Trypsin Investigated Using a Genetic Selection. Natl. Acad. Sci. USA 87

  317. Untitled Publication

    A.L. Ferris, A. Hizi, S.D. Showalter, S. Pichuantes, L. Babé & C.S. Craik. Immunologic and Proteolytic Analysis of HIV-2 Reverse Transcriptase Structure. Virology 175

  318. Untitled Publication

    E. Stewart, C.S. Craik, L. Hake & A. Bowcock. Human CPA Identifies a BglII RFLP and Maps to 7q31-qter. Amer. J. Hum. Gen. 46, 795 -800

  319. Untitled Publication

    M. Obukowicz, M. Gustafson, K. Junger, R. Leimgruber, A. Wittwer, T-C. Wun, T. Warren, B. Bishop, K. Mathis, D. McPherson, N. Siegel, M. Jennings, B. Brightwell, J. Diaz-Collier, L. Bell, C.S. Craik & W. Tacon. Secretion of Active Kringle 2-Serine Protease in E. coli. J. Bio. Chem. 29, 9737-9745

  320. Untitled Publication

    S. Pichuantes, L. Babé, P. Barr, D. DeCamp & C.S. Craik. Recombinant HIV 2 Protease Processes HIV 1 Pr53gag and Analogous Junction Peptides In Vitro. J. Bio. Chem. 265, 13890-13898

  321. Crystal structures of two engineered thiol trypsins


    McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ

  322. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes

    Proceedings of the National Academy of Sciences of the United States of America

    Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH

  323. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation


    Vanderslice P, Craik CS, Nadel JA, Caughey GH

  324. An expression system for trypsin

    Journal of cellular biochemistry

    Vasquez JR, Evnin LB, Higaki JN, Craik CS

  325. Rapid preparation of proteins for crystallization trials


    McGrath ME, Fletterick RJ, Craik CS

  326. [A case of aseptic meningoencephalitis with recurrent abnormal behavior, status epilepticus and aphthous stomatitis, improved by acyclovir]

    Rinsho shinkeigaku = Clinical neurology

    Shimada K, Koh CS, Hashimoto T, Shoji S, Yanagisawa N

  327. Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases

    Advances in prostaglandin, thromboxane, and leukotriene research

    Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA

  328. Cloning and expression of human arachidonate 15-lipoxygenase

    Transactions of the Association of American Physicians

    Sigal E, Craik CS, Dixon RA, Nadel JA

  329. Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein


    Pichuantes S, Babé LM, Barr PJ, Craik CS

  330. Untitled Publication

    A. Eakin, J.N. Higaki, J.H. McKerrow & C.S. Craik. Cysteine or Serine Proteinase. Nature 342,132

  331. Untitled Publication

    J. Higaki L.B. Evnin & C.S. Craik. Introduction of a Cysteine Protease Active Site into Trypsin. Biochem. 28, 9256-9263

  332. Molecular cloning and primary structure of human 15-lipoxygenase

    Biochemical and biophysical research communications

    Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA

  333. Structural and functional integrity of specificity and catalytic sites of trypsin

    International journal of peptide and protein research

    Gráf L, Hegyi G, Likó I, Hepp J, Medzihradszky K, Craik CS, Rutter WJ

  334. A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family

    The Journal of biological chemistry

    Gardell SJ, Craik CS, Clauser E, Goldsmith EJ, Stewart CB, Graf M, Rutter WJ

  335. Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family

    The Journal of biological chemistry

    Clauser E, Gardell SJ, Craik CS, MacDonald RJ, Rutter WJ

  336. Efficient targeting to storage granules of human proinsulins with altered propeptide domain

    The Journal of cell biology

    Powell SK, Orci L, Craik CS, Moore HP

  337. Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases

    The Journal of biological chemistry

    Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA

  338. Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties

    Biochemical and biophysical research communications

    Sigal E, Grunberger D, Cashman JR, Craik CS, Caughey GH, Nadel JA

  339. Development of an efficient method for generating and screening active trypsin and trypsin variants

    Annals of the New York Academy of Sciences

    Evnin LB, Craik CS

  340. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants

    Critical reviews in biotechnology

    Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS

  341. The catalytic role of the active site aspartic acid in serine proteases

    Science (New York, N.Y.)

    Craik CS, Roczniak S, Largman C, Rutter WJ

  342. The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis

    Science (New York, N.Y.)

    Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS

  343. Isolation and characterization of a cDNA encoding rat cationic trypsinogen


    Fletcher TS, Alhadeff M, Craik CS, Largman C

  344. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin


    Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ

  345. Redesigning trypsin via genetic engineering

    Journal of cellular biochemistry

    Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W

  346. Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

    Proceedings of the National Academy of Sciences of the United States of America

    Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ

  347. Evolution of catalysis in the serine proteases

    Cold Spring Harbor symposia on quantitative biology

    Higaki JN, Gibson BW, Craik CS

  348. Untitled Publication

    C.S. Craik, S. Roczniak, S. Sprang, R.J. Fletterick & W.J. Rutter. Edited by D. Cunningham and G. Long. New York: Alan R Liss, Inc. Redesigning Trypsin via Genetic Engineering. In: Proteases in Biological Control and Biotechnology

  349. Untitled Publication

    C.S. Craik. Edited by D. Oxender. New York: Alan R. Liss, Inc. Expression and Overproduction of Proteins. In: Protein Structure, Folding and Design 2, pp. 467-476.

  350. Untitled Publication

    T.L. Burgess, C.S. Craik, L. Matsuuchi & R.B. Kelly. In Vitro Mutagenesis of Trypsinogen: The Role of the N-Terminus in Intracellular Protein Targeting to Secretory Granules. J. Cell Bio. 105, 659-668

  351. Untitled Publication

    W.J. Rutter, S.J. Gardell, S. Roczniak, D. Hilvert, S. Sprang, R.J. Fletterick & C.S. Craik. Edited by D. Oxender and C.F. Fox. New York: Alan R. Liss, Inc. Redesigning Proteins via Genetic Engineering. In: Protein Modification and Design, pp. 257-267

  352. Genetic analysis of cystic fibrosis: linkage of DNA and classical markers in multiplex families

    American journal of human genetics

    Bowcock AM, Crandall J, Daneshvar L, Lee GM, Young B, Zunzunegui V, Craik C, Cavalli-Sforza LL, King MC

  353. Untitled Publication

    S. Gardell, C.S. Craik, D. Hilvert, M. Urdea & W. Rutter. Edited by I. Bertini, C. Luchinat, W. Maret, and M. Zeppezauer. Boston, Massachusetts: Birkhäuser. Probing the Role of Tyrosine 248 in Carboxypeptidase A with Site-Directed Mutagenesis. In: Comparative Analysis of Catalytic Mechanisms of Zinc Enzymes.

  354. Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis


    Gardell SJ, Craik CS, Hilvert D, Urdea MS, Rutter WJ

  355. The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer

    The Journal of cell biology

    Burgess TL, Craik CS, Kelly RB

  356. Redesigning trypsin: alteration of substrate specificity

    Science (New York, N.Y.)

    Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ

  357. Biotechniques

    Use of Oligonucleotides for Site-Specific Mutagenesis

    C.S. Craik

  358. Isolation and sequence of a rat chymotrypsin B gene

    The Journal of biological chemistry

    Bell GI, Quinto C, Quiroga M, Valenzuela P, Craik CS, Rutter WJ

  359. Structure of the two related elastase genes expressed in the rat pancreas

    The Journal of biological chemistry

    Swift GH, Craik CS, Stary SJ, Quinto C, Lahaie RG, Rutter WJ, MacDonald RJ

  360. Structure of two related rat pancreatic trypsin genes

    The Journal of biological chemistry

    Craik CS, Choo QL, Swift GH, Quinto C, MacDonald RJ, Rutter WJ

  361. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse

    Somatic cell and molecular genetics

    Honey NK, Sakaguchi AY, Lalley PA, Quinto C, MacDonald RJ, Craik C, Bell GI, Rutter WJ, Naylor SL

  362. Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase

    Somatic cell and molecular genetics

    Honey NK, Sakaguchi AY, Quinto C, MacDonald RJ, Bell GI, Craik C, Rutter WJ, Naylor SL

  363. Splice junctions: association with variation in protein structure

    Science (New York, N.Y.)

    Craik CS, Rutter WJ, Fletterick R

  364. Intron-exon splice junctions map at protein surfaces


    Craik CS, Sprang S, Fletterick R, Rutter WJ

  365. Untitled Publication

    C.S. Craik & S. Beychok. Edited by C. Ho. In: Interaction Between Iron Proteins in Oxygen and Electron Transport, Elsevier North Holland Biomedical Press

  366. O2 binding properties of the product of the central exon of beta-globin gene


    Craik CS, Buchman SR, Beychok S

  367. Refolding defects in hemoglobin Rothschild

    The Journal of biological chemistry

    Craik CS, Vallette I, Beychok S, Waks M

  368. Characterization of globin domains: heme binding to the central exon product

    Proceedings of the National Academy of Sciences of the United States of America

    Craik CS, Buchman SR, Beychok S