UCSF

Exciting Winter-Spring Quarter in the DeGrado Lab

We've had a busy winter and spring. This is a quick update of the lab fun, science adventures, and research highlights since then.

 

Lab hang-outs:

Lili and Bill on Administrator Appreciation Day 2019, also DGL Waffle Wednesday

 

Mid-day break for birthday pastries

Another DGL birthday celebration

 

Francis Arnold, 2019 Nobel winner visits UCSF & DeGrado Lab

 

 

Bill headlines International Peptide Society meeting in Kyoto + Lab hang-outs abroad

Bill giving his keynote lecture near Kyoto University

   photo

 

We also published a bunch of exciting articles! Here are a few highlights

 

Membrane protein design:  

Mravic et al 2019, Science.

"Packing of apolar side chains enables accurate design of highly stable membrane proteins" in Science. (2019) 363(6434):1418-23.

 

Peptide Chemistry:

Sequence specific peptide bond cleavage induced by nickle

"SNAC-tag for sequence-specific chemical protein cleavage" in Nature Methods. (2019) 16(4):319-322.  Led by DGL post-doc Bobo Dang.

 

Molecular tools for Neuroscience:

Custom infrared probe for amyloid fiber formation

"Glutamine side chain 13C= 18O as a non-perturbative IR probe of amyloid fibril hydration and assembly" in JACS. (2019). Led by DGL post-doc Haifan Wu and in collaboration with UCSF Sali lab.