People
Principal investigator
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Who |
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William DeGrado, PhD |
De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design |
Senior scientists
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Who |
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Hyunil Jo, PhD |
Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life |
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Yibing Wu, PhD |
Structure and dynamics of proteins using multidimensional NMR spectroscopy; protein modelling and drug docking. |
Postdoctoral scholars
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Who |
Research interests |
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Ketaki Belsare, PhD |
Design, characterization and evolution of de novo proteins for small molecule biocatalysis |
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Matthew Chalkley, PhD |
Design and characterization of de novo metalloproteins for better understanding of structure-function relationships in enzymatic reactions. |
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Hyun Jun Yang, PhD |
Molecular fingerprinting of prion strains in vivo and in vitro |
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Huong Tran Kratochvil, PhD |
Influenza A and B matrix protein structure and mechanism; de novo design of ion channels |
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Lam-Kiu Fong Eiranova, PhD |
Structure and dynamics of membrane protein receptors, molecular dynamics simulations |
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Samuel Mann, PhD |
Design and characterization of de novo proteins to bind non-biological, inorganic cofactors; development of structure-function relationships for artificial metalloenzyme catalysis |
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Kehan Chen, PhD |
De novo design and characterization of membrane proteins, especially transporters and channels |
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Nicholas Polizzi, PhD |
Design and characterization of de novo proteins that selectively bind small molecules |
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Lee Schnaider, PhD |
Design and characterization of de novo proteins for biomedical applications |
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Sam Schneider, PhD |
Design and characterization of de novo proteins for enzymatic catalysis |
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Lei Lu, PhD |
Study protein structures, PTMs and interactions using bioengineering, proteomics and design methods. |
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Bruk Mensa |
Structure and signal transduction mechanism of bacterial two component system histidine kinases; mechanism of action of antimicrobial peptide mimetics |
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Katie Hatstat |
Design and characterization of transmembrane proteins and signaling mechanisms |
Graduate students
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Who |
Research interests |
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Sophia Tan |
Automated de novo design of ligand-binding proteins using structural proteomics |
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Hailey Wallace |
Design and characterization of de novo proteins for investigating the amyloid fibril formation pathway |
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Rian Kormos |
De novo design and single-molecule force spectroscopy of proteins with mechano-sensitive functions |
Co-mentored graduate students and postdoctoral scholars
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Who |
Research interests |
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Jonathan Boyce, PhD |
Development of improved protease-activated antibiotics |
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Ethel Tackie-Yarboi, PhD |
Synthesis and functional characterization of AND-gated cancer therapeutics |
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Leo Chen |
Development of protease-activated tumor imaging agents and cancer therapeutics |
Visiting scholars
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Who |
Research interests |
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Julia Shifman |
Protein evolution and design, engineering of inhibitors of protein-protein interactions |
Current & Recent undergraduates and high school students
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Who |
Research interests |
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Junyi Xu |
Protein design |
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Jiage Song |
Protein design |
Administrative staff
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WHO |
What I do |
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Angie Galvis |
Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars |