Research laboratory of William DeGrado, PhD

People

Principal investigator

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Who

Research Interests

William DeGrado, PhD

William DeGrado, PhD
Professor and Principal Investigator
[email protected]

De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design

Senior scientists

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Who

Research Interests

Hyunil Jo, PhD

Hyunil Jo, PhD
Specialist, Lab Manager
[email protected]

Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life

Yibing Wu, PhD

Yibing Wu, PhD
NMR Specialist
[email protected]

Structure and dynamics of proteins using multidimensional NMR spectroscopy; structural studies of the M2 protein from influenza

Postdoctoral scholars

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Who

Research Interests

Bobo Dang

Bobo Dang, PhD
Postdoctoral Scholar
[email protected]

Protein/peptide therapeutics

Huong Tran Kratochvil   

 

Influenza A and B matrix protein structure and mechanism

Thomas Lemmin, PhD

Thomas Lemmin, PhD
Postdoctoral Scholar
[email protected]

Integrative molecular modeling of oligomeric proteins; structural refinement and dynamics using molecular dynamics simulations

Robert Newberry, PhD

Exploring molecular determinants of protein folding, misfolding, and amyloid formation through chemical biology and biophysics

Nicholas Polizzi, PhD

Design and characterization of de novo proteins that selectively bind small molecules

Nathan Schmidt, PhD

Nathan Schmidt, PhD
Postdoctoral Scholar
[email protected]

Bacterial systems which detect host defense antimicrobial peptides; role of bacterial response to antimicrobials in virulence and resistance; two-component system signaling in microbes

Gozde Ulas

Gözde Ulas, PhD
Postdoctoral Scholar
[email protected]

Accessing and modulating reactivity of de novo metalloproteins by protein design, biochemical, and biophysical methods

Haifan Wu

Haifan Wu, PhD
Postdoctoral Scholar
[email protected]

Stapled peptides targeting protein-nucleic acid interactions; specific imaging agents for integrin αvβ1

Shaoqing Zhang, PhD

Shao-Qing Zhang, PhD
Postdoctoral Scholar
[email protected]

Design de novo helix bundles, water soluble or membrane associated; build model systems for folding and/or functional studies; invent nanomaterials for biological applications

Graduate students

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Who

Research Interests

Bruk Mensa

Bruk Mensa
Chemistry and Chemical Biology (CCB) program
[email protected]

Structure and signal transduction mechanism of bacterial two component system histidine kinases; mechanism of action of antimicrobial peptide mimetics

Marco Mravic

Marco Mravic
Biophysics (BP) program (iPQB)
[email protected]

De novo design of functional membrane proteins; modeling and molecular dynamics simulations; protein-driven membrane distortions; protein evolution and machine learning

Sophia Tan
Bioinformatics (BMI) program (iPQB)
[email protected]

Automated de novo design of ligand-binding proteins using structural proteomics

Jessica Thomaston

Jessica Thomaston
Chemistry and Chemical Biology (CCB) program
[email protected]

Membrane protein structure using x-ray crystallography; influenza M2 proton channel structure, mechanism, and drug resistance

Visiting scholars

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Who

Research Interests

Sid Das

Sid Das, PhD
Visiting Professor
[email protected]

Making protein matrix for drug release

Administrative staff

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WHO

WHAT I DO

Lili Li

Lili Li
Administrative Analyst
[email protected]

Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars