UCSF

People

Principal investigator

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Who

Research interests

DeGrado

William DeGrado, PhD
Professor and Principal Investigator

[email protected]

UCSF profile

De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design

Senior scientists

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Who

Research interests

Jo

Hyunil Jo, PhD
Assistant Adjunct Professor

[email protected]

Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life

Postdoctoral scholars

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Who

Research interests

Matthew Chalkley, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo metalloproteins for better understanding of structure-function relationships in enzymatic reactions.

Hyun Jun Yang, PhD
Postdoctoral Scholar

[email protected]

Molecular fingerprinting of prion strains in vivo and in vitro

Huong Tran Kratochvil, PhD
Postdoctoral Scholar

[email protected]

Influenza A and B matrix protein structure and mechanism; de novo design of ion channels

Lam-Kiu Fong Eiranova, PhD
Postdoctoral Scholar

[email protected]

Structure and dynamics of membrane protein receptors, molecular dynamics simulations
Mann

Samuel Mann, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins to bind non-biological, inorganic cofactors; development of structure-function relationships for artificial metalloenzyme catalysis

Kehan Chen, PhD
Postdoctoral Scholar

[email protected]

De novo design and characterization of membrane proteins, especially transporters and channels

Lee Schnaider, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins for biomedical applications

Sam Schneider, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins for enzymatic catalysis

Lei Lu, PhD
Postdoctoral Scholar

[email protected]

Study protein structures, PTMs and interactions using bioengineering, proteomics and design methods.

Ethel Tackie-Yarboi, PhD
Postdoctoral Scholar

[email protected]

Synthesis and functional characterization of AND-gated cancer therapeutics

Katie Hatstat
Postdoctoral Scholar

[email protected]

Design and characterization of transmembrane proteins and signaling mechanisms 

Graduate students

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Who

Research interests

Sophia Tan
Biophysics (BP) program

[email protected]

Automated de novo design of ligand-binding proteins using structural proteomics

Hailey Wallace
Biophysics (BP) program

[email protected]

Design and characterization of de novo proteins for investigating the amyloid fibril formation pathway 

Rian Kormos
Biophysics (BP) program

[email protected]

De novo design and single-molecule force spectroscopy of proteins with mechano-sensitive functions

Rose Yang
Chemistry and Chemical Biology (CCB) program

[email protected]

Design and characterization of de novo peptides for targeting tau polymorphs present in Alzheimer's disease 
 

Stephanie Ouchida
Chemistry and Chemical Biology (CCB) program

[email protected]

 

Co-mentored graduate students and postdoctoral scholars

Postdoctoral scholars

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Who

Research interests

Jonathan Boyce, PhD
Postdoctoral Scholar

[email protected]

Development of improved protease-activated antibiotics

Leo Chen
Chemistry and Chemical Biology (CCB) program

[email protected]

Development of protease-activated tumor imaging agents and cancer therapeutics

Visiting scholars

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Who

Research interests

Julia Shifman
Professor
The Hebrew University of Jerusalem

[email protected]

Protein evolution and design, engineering of inhibitors of protein-protein interactions

Ismael Mingarro
Professor
University of Valencia

[email protected]

Membrane protein insertion and assembly; apoptosis; viral membrane proteins

Current & Recent undergraduates and high school students

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Who

Research interests

Junyi Xu
Undergraduate student
University of California, Berkeley

[email protected]

Protein design

Jiage Song
Undergraduate student
University of California, Berkeley

[email protected]

Protein design
 

Gabrielle Kroepfl 
Undergraduate student
Scripps college

[email protected]

Amyloid

Associated adjunct faculty

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Who

Research interests

Yibing Wu, PhD
Assistant Adjunct Professor

[email protected]

Structure and dynamics of proteins using multidimensional NMR spectroscopy
protein modelling and drug docking
deep learning-based protein design and drug discovery

Administrative staffs

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WHO

What I do

Kazuko Olson
Administrative Assistant

[email protected]

Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars