People
Principal investigator
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Who |
Research Interests |
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William DeGrado, PhD |
De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design |
Senior scientists
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Who |
Research Interests |
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Hyunil Jo, PhD |
Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life |
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Yibing Wu, PhD |
Structure and dynamics of proteins using multidimensional NMR spectroscopy; protein modelling and drug docking. |
Postdoctoral scholars
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Who |
Research Interests |
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Ketaki Belsare, PhD |
Design, characterization and evolution of de novo proteins for small molecule biocatalysis |
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Bobo Dang, PhD |
Protein/peptide therapeutics |
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Huong Tran Kratochvil Postdoctoral Scholar [email protected]
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Influenza A and B matrix protein structure and mechanism |
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Samuel Mann, PhD |
Design and characterization of de novo proteins to bind non-biological, inorganic cofactors; development of structure-function relationships for artificial metalloenzyme catalysis |
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Robert Newberry, PhD |
Exploring molecular determinants of protein folding, misfolding, and amyloid formation through chemical biology and biophysics |
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Sungkyu Park, PhD |
Computational drug design, Integrin inhibitors |
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Nicholas Polizzi, PhD |
Design and characterization of de novo proteins that selectively bind small molecules |
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Nathan Schmidt, PhD |
Bacterial systems which detect host defense antimicrobial peptides; role of bacterial response to antimicrobials in virulence and resistance; two-component system signaling in microbes |
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Haifan Wu, PhD |
Stapled peptides targeting protein-nucleic acid interactions; specific imaging agents for integrin αvβ1 |
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Kui Zhang, PhD |
Medicinal chemistry; applying de novo designed proteins for biocatalysis |
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Shao-Qing Zhang, PhD |
Design de novo helix bundles, water soluble or membrane associated; build model systems for folding and/or functional studies; invent nanomaterials for biological applications |
Graduate students
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Who |
Research Interests |
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Alison Maxwell |
Amyloid structure and neuropathological heterogeneity in Alzheimer’s disease |
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Bruk Mensa |
Structure and signal transduction mechanism of bacterial two component system histidine kinases; mechanism of action of antimicrobial peptide mimetics |
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Marco Mravic |
De novo design of functional membrane proteins; modeling and molecular dynamics simulations; protein-driven membrane distortions; protein evolution and machine learning |
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Sophia Tan |
Automated de novo design of ligand-binding proteins using structural proteomics |
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Jessica Thomaston |
Membrane protein structure using x-ray crystallography; influenza M2 proton channel structure, mechanism, and drug resistance |
Visiting scholars
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Who |
Research Interests |
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None Currently... |
Administrative staff
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PHOTO |
WHO |
WHAT I DO |
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Lili Li |
Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars |