UCSF

People

Principal investigator

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Who

Research interests

DeGrado

William DeGrado, PhD
Professor and Principal Investigator

[email protected]

UCSF profile

De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design

Senior scientists

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Who

Research interests

Jo

Hyunil Jo, PhD
Assistant Adjunct Professor

[email protected]

Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life

Wu

Yibing Wu, PhD
Assistant Adjunct Professor

[email protected]

Structure and dynamics of proteins using multidimensional NMR spectroscopy; protein modelling and drug docking.

Postdoctoral scholars

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Who

Research interests

Belsare

Ketaki Belsare, PhD
Postdoctoral Scholar

[email protected]

Design, characterization and evolution of de novo proteins for small molecule biocatalysis

Matthew Chalkley, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo metalloproteins for better understanding of structure-function relationships in enzymatic reactions.

Hyun Jun Yang, PhD
Postdoctoral Scholar

[email protected]

Molecular fingerprinting of prion strains in vivo and in vitro
Kratochvil

Huong Tran Kratochvil, PhD
Postdoctoral Scholar

[email protected]

Influenza A and B matrix protein structure and mechanism

Lam-Kiu Fong Eiranova, PhD
Postdoctoral Scholar

[email protected]

Structure and dynamics of membrane protein receptors, molecular dynamics simulations
Mann

Samuel Mann, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins to bind non-biological, inorganic cofactors; development of structure-function relationships for artificial metalloenzyme catalysis

Greg Merz, PhD
Postdoctoral Scholar

[email protected]

Structure of amyloid filaments involved in neurodegeration, cryo-electron microscopy
Newberry.

Robert Newberry, PhD
Postdoctoral Scholar

[email protected]

Exploring molecular determinants of protein folding, misfolding, and amyloid formation through chemical biology and biophysics

Polizzi.

Nicholas Polizzi, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins that selectively bind small molecules

Lee Schnaider, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins for biomedical applications

Sam Schneider, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins for enzymatic catalysis

Lei Lu, PhD
Postdoctoral Scholar

[email protected]

Study protein structures, PTMs and interactions using bioengineering, proteomics and design methods.
Mensa

Bruk Mensa
Postdoctoral Scholar

[email protected]

Structure and signal transduction mechanism of bacterial two component system histidine kinases; mechanism of action of antimicrobial peptide mimetics

Katie Hatstat
Postdoctoral Scholar

[email protected]

Design and characterization of transmembrane proteins and signaling mechanisms 

Nina Hentzen, PhD
Postdoctoral Scholar

[email protected]

de novo design of dynamic and stimuli-responsive proteins

Graduate students

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Who

Research interests

Tan

Sophia Tan
Bioinformatics (BMI) program (iPQB)

[email protected]

Automated de novo design of ligand-binding proteins using structural proteomics

Hailey Wallace
Biophysics (BP) program

[email protected]

Design and characterization of de novo proteins for investigating the amyloid fibril formation pathway 

Rian Kormos
Biophysics (BP) program

[email protected]

De novo design and single-molecule force spectroscopy of proteins with mechano-sensitive functions

Visiting scholar

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Who

Research interests

Julia Shifman
Professor
The Hebrew University of Jerusalem

[email protected]

Protein evolution and design, engineering of inhibitors of protein-protein interactions

Administrative staff

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WHO

What I do

Miranda Paulos
Administrative Analyst

[email protected]

Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars