People

Principal investigator

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Who

Research interests, hobbies

DeGrado

William DeGrado, PhD
Professor and Principal Investigator

[email protected]

UCSF profile

De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design

Cycling, Music, Dance

Senior scientists

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Who

Research interests

Jo

Hyunil Jo, PhD
Assistant Adjunct Professor

[email protected]

Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life

Postdoctoral scholars

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Who

Research interests, hobbies

Hyunjun Yang, PhD
Postdoctoral Scholar

[email protected]

Molecular fingerprinting of prion strains in vivo and in vitro

Golf

Kehan Chen, PhD
Postdoctoral Scholar

[email protected]

De novo design and characterization of membrane proteins, especially transporters and channels

Mineralogy and linguistics

Lee Schnaider, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo proteins for biomedical applications

Redwood and mountain enthusiast. I love hiking, reading and live music.

Ethel Tackie-Yarboi, PhD
Postdoctoral Scholar

[email protected]

Synthesis and functional characterization of AND-gated cancer therapeutics

Reading, cooking, and spending time with family

Katie Hatstat, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of transmembrane proteins and signaling mechanisms

Running, soccer, making up recipes, and adventuring in the mountains with her dog

Yuda Chen, PhD
Postdoctoral Scholar

[email protected]

Protein design with chemical biology

Henry Pan, PhD
Postdoctoral Scholar

[email protected]

Amyloids, cryo-EM, fluorescence microscopy, and peptide design

Running, rugby, sailing, playing the piano, cooking plant-based recipes

Kaipeng Hou, PhD
Postdoctoral Scholar

[email protected]

De novo metalloprotein design

Sophia Tan, PhD
Postdoctoral Scholar

[email protected]

Automated de novo design of ligand-binding proteins using structural proteomics
Board games, rock climbing

Ian Bakanas, PhD
Postdoctoral Scholar

[email protected]

Design and characterization of de novo enzymes to catalyze new-to-nature transformations

Baking bread, watching basketball, and playing tennis poorly

Sagar Bhattacharya, PhD
Postdoctoral Scholar

[email protected]

De novo protein design for enzyme catalysis and drug delivery in vivo

Chess

Nam Hyeong Kim, PhD
Postdoctoral Scholar

[email protected]

Function-directed protein design for biomedical applications with a parametrized scaffold and protein structure prediction incorporating molecular dynamics
Drumming, watching football, and sitting in the park

Adam McConnell, PhD
Postdoctoral Scholar

[email protected]

De novo protein design towards pharmaceutical and biomedical applications
Watching stand-up comedy, drumming, reading scifi/fantasy novels, solving nonograms

Maggie Horst, PhD

Postdoctoral Scholar

[email protected]

De novo protein design and characterization
Reading groups, bird watching, and vegetarian cooking

Graduate students

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Who

Research interests, hobbies

Rian Kormos
Biophysics (BP) program

[email protected]

Development and validation of improved algorithms for de novo design of small molecule impermeable nanostructures

In my free time, I enjoy long walks around the city, backpacking, teaching myself the piano, and playing Dungeons & Dragons.

Rose Yang
Chemistry and Chemical Biology (CCB) program

[email protected]

Design and characterization of de novo peptides for targeting tau polymorphs present in Alzheimer's disease

Outside of the lab, I enjoy reading, cooking, and going on runs through Golden Gate Park.

Stephanie Ouchida
Chemistry and Chemical Biology (CCB) program

[email protected]

Design of de novo small molecule binding proteins for drug delivery

I enjoy rock climbing, playing basketball, going to the gym, playing video games, all things BTS, and drinking boba!

Henry Scott
Biophysics (BP) program

[email protected]

Design and characterization of bioorthogonal intercellular signaling systems.
Outside of lab I enjoy surfing, reading, playing chess, and searching for frog-themed memes.

Angelika Arada
Biophysics (BP) program

[email protected]

Design and characterization of de novo proteins for small molecule binding
Outside of lab, I like going to concerts, trying new restaurants, and playing video games.

Nicholas Freitas
Biophysics (BP) program

[email protected]

Development of Physics-based computational methods for de novo enzyme design.
Camping, hiking, photography, and astronomy

Giovanni Aviles
Biophysics (BP) program

[email protected]

Design and characterization of artificial metalloenzymes

Outside of lab, I enjoy climbing, traveling, and learning languages

Haoyu Fan
Chemistry and Chemical Biology (CCB) program

[email protected]

Deep learning applied to de novo design and biocatalysis
In my free time I like playing ultimate frisbee, badminton and video games like Valorant and Dota2

Adjunct Emeritus Professors

Photo Who Research interests, hobbies

William (Willi) Fish DeGrado, PsyD PhD

Emeritus Betta

Electron tomography of phase condensates, in vivo PyMOL palette visualization, isolation and characterization of aquatic natural products
Perching on his petri dish, hanging out in his coconut, providing emotional support for lab members

Visiting scholars

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Who

Research interests, hobbies

Associated adjunct faculty

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Who

Research interests

Yibing Wu, PhD
Assistant Adjunct Professor

[email protected]

Structure and dynamics of proteins using multidimensional NMR spectroscopy
protein modelling and drug docking
deep learning-based protein design and drug discovery

Administrative staff

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Who

What I do, hobbies

Nell John Layno
Administrative Assistant

[email protected]

Support administrative, organizational, and scheduling needs for the lab

Weightlifting, running, playing/watching sports, and concert-going