People
Principal investigator
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Who |
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William DeGrado, PhD |
De novo protein design; membrane proteins; small molecule drug discovery for antimicrobials, influenza A virus, antifibrotics, and neurodegeneration; chemical biology; peptide design |
Senior scientists
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Who |
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Hyunil Jo, PhD |
Medicinal chemistry to fight against unconquered human diseases; chemical biology to understand the fundamental processes in life |
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Yibing Wu, PhD |
Structure and dynamics of proteins using multidimensional NMR spectroscopy; protein modelling and drug docking. |
Postdoctoral scholars
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Who |
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Ketaki Belsare, PhD |
Design, characterization and evolution of de novo proteins for small molecule biocatalysis |
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Matthew Chalkley, PhD Postdoctoral Scholar [email protected] |
Design and characterization of de novo metalloproteins for better understanding of structure-function relationships in enzymatic reactions. |
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Yang Hyun Jun, PhD Postdoctoral Scholar [email protected] |
Molecular fingerprinting of prion strains in vivo and in vitro |
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Huong Tran Kratochvil, PhD |
Influenza A and B matrix protein structure and mechanism |
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Lam-Kiu Fong Eiranova, PhD Postdoctoral Scholar [email protected] |
Structure and dynamics of membrane protein receptors, molecular dynamics simulations |
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Samuel Mann, PhD |
Design and characterization of de novo proteins to bind non-biological, inorganic cofactors; development of structure-function relationships for artificial metalloenzyme catalysis |
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Greg Merz, PhD Postdoctoral Scholar [email protected] |
Structure of amyloid filaments involved in neurodegeration, cryo-electron microscopy |
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Robert Newberry, PhD |
Exploring molecular determinants of protein folding, misfolding, and amyloid formation through chemical biology and biophysics |
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Nicholas Polizzi, PhD |
Design and characterization of de novo proteins that selectively bind small molecules |
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Lee Schnaider, PhD Postdoctoral Scholar [email protected] |
Design and characterization of de novo proteins for biomedical applications |
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Haifan Wu, PhD |
Stapled peptides targeting protein-nucleic acid interactions; specific imaging agents for integrin αvβ1 |
Graduate students
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Who |
Research interests |
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Alison Maxwell |
Amyloid structure and neuropathological heterogeneity in Alzheimer’s disease |
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Bruk Mensa |
Structure and signal transduction mechanism of bacterial two component system histidine kinases; mechanism of action of antimicrobial peptide mimetics |
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Marco Mravic |
De novo design of functional membrane proteins, chemical biology tools targeting membrane-spanning domains, bioinformatics, molecular dynamics simulations |
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Sophia Tan |
Automated de novo design of ligand-binding proteins using structural proteomics |
Visiting scholars
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Who |
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Jia Jin, PhD |
Administrative staff
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WHO |
What I do |
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Miranda Paulos |
Serve as point of contact for administrative inquiries; support administrative needs; coordinate visits from guest speakers; manage calendars |