DeGrado Lab

Our research focuses on small molecule and protein design as an approach to understanding macromolecule structure and function.

News

  • SLAC protein illustration

    Fraser, DeGrado Pioneer Method to Rapidly Design Proteins

    A UCSF research team led by Department of Bioengineering and Therapeutic Sciences Chair and Professor James Fraser, PhD and Department of Pharmaceutical Chemistry Professor William DeGrado, PhD, has pioneered a breakthrough approach to designing proteins with targeted functions, which could lead to simpler ways to improve enzymes and medications, among other uses, according to a new study published in Nature Chemistry. 

  • protein ribbon structure

    Suzan Revah

    Reprogramming Nature: UCSF Leads AI-Driven Protein Design Initiative

    Professors William DeGrado, PhD, and Tanja Kortemme, PhD, have landed three out of five inaugural awards given by the U.S. National Science Foundation (NSF) that aim to strengthen the bioeconomy by translating advances in AI into real-world biotechnologies that support domestic manufacturing, sustainable materials, and resilient supply chains.