UCSF

People

Principal investigator

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Who

Research interests

Giacomini

Kathleen M. Giacomini, PhD

Professor and Principal Investigator

[email protected]

Understanding the roles of membrane transporters in drug absorption, disposition, targeting, and in clinical drug response. Discovering natural variants in transporter genes in ethnically diverse human populations that associate with variation in drug response

Administration

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Who

 
Ilona Paredes

Ilona Paredes

Administrative Analyst

[email protected]

 

Senior researchers

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Who

Research interests

Yee

Sook Wah Yee, PhD

Assistant Adjunct Professor

[email protected]

 

  • Investigating the discovery of transporters as drug targets
  • Utilizing genomewide data to identify transporter endogenous role and drug pharmacological action

Staff

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Who

Responsibilities

Lin

Lawrence Lin, PhD

Project Director

[email protected]

 

Srinivasan

Shylaja Srinivasan

Clinical Instructor

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  • Clinical Instructor in Pediatric Endocrinology

Postdocs

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Who

Research interests

Cheung

Kathy Cheung

Postdoctoral Scholar

[email protected]

  • Understanding the ontogenic changes in human renal transporters to better predict drug exposure in special populations
Chien

James Huan-Chieh Chien, PhD

Postdoctoral Scholar

[email protected]

 

  • Understanding the role of organic cation transporter 1 (OCT1) and its-mediated drug-drug interactions
  • Pharmacogenomics studies of SLC2A2 and metformin
Ennis

Elizabeth Ennis

Postdoctoral Scholar

[email protected]

  • Understanding the genetic determinates of metformin response through the use of GWAS, clinical studies, and cellular-based approaches
Zou

Ling Zou, PhD

Postdoctoral Scholar

[email protected]

 

  • Understanding species difference in renal transporters to better predict dosing and prevent drug-induced nephrotoxicity in humans
  • Examining interactions of excipients with intestinal influx transporters which may affect drug bioavailability and bioequivalence
Stecula

Adrian Stecula, PhD

Postdoctoral Scholar

[email protected]

 

  • Structure determination of human SLC transporters; design of novel ligands using structure-based approaches
  • Understanding the function and regulation of the human SLC28 family on the structural level

Graduate students

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Who

Research interests

Brackman

Deanna Brackman

Graduate Student Researcher, Pharmaceutical Sciences and Pharmacogenomics

[email protected]

 

  • Discovery of genetic factors that contribute to variability in allopurinol response to create a genetic risk model for more precise prescription of uric-acid-lowering medications
Enogieru

Jessica Enogieru, PharmD, BCPS

Graduate Student, Pharamceutical Sciences and Pharmacogenomics

[email protected]

 

  • Discovery, analysis, and functional characterization of genetic factors that influence anti-hyperglycemic drug response to metformin
Chang

Yu-Chuan (Chester) Chang

Exchange Student

y[email protected]

  • Discovering Alzheimer's Disease-related or drug response-related epistasis by machine learning
Tung

Yi-An Tung

Exchange Student

[email protected]

 

  • Using deep learning to predict cross-cell type enhancer activities with genomic and non-genomic features
  • Discover genetic variations in metformin extreme response cohort