Optional Half-day Courses


The passage of drugs across membranes: without transport vs. by passive transport vs. by active transport.

Transporters in Drug Development

Half-Day Course: Friday, February 24, 2023, 12:30 to 5:00 pm

Membrane transporters are critical determinants of drug disposition, response, and toxicity, and increasingly are being targeted in drug discovery. This half-day workshop will, through lectures and interactive problem-solving, focus on transporters in the Solute Carrier and ATP Binding Cassette Superfamilies (Nature Reviews Drug Discovery 9, 215-236, 2010), including fundamentals of transport mechanisms and kinetics, in vitro methodology for studying those mechanisms, FDA guidances for studies of transporter-mediated DDIs, and transporter polymorphisms. The emphasis will be on emerging transporters, and case based problems. (Instructors: Kathy Giacomini (UCSF), Deanna Kroetz (UCSF), and Eugene Chen (Genentech)


A pharmacokinetic population model. Once established, models such as this can enable individualization of drug therapy for a specific patient to be more finely focused.

Introduction to Population Pharmacokinetics

Half-Day Course: Friday, February 24, 2023, 12:30 to 5:00 pm

Population Pharmacokinetics is the study of sources of variability in drug disposition and effects. It seeks to characterize quantitatively both the distribution of pharmacokinetic behaviors (and drug effects) throughout a population of subjects, and the separate contributions to that distribution by component subpopulations (see adjacent figure). It is an area of strong research interest, it is common practice in drug development, and it is often used in comprehensive PK/PD modeling, particularly to support simulations of future trials. This course will introduce participants to the concepts and important applications, provide an understanding of the components of population PK, and allow simple calculations that reinforce the concepts. It will also introduce participants to NONMEM® (Icon®), a widely used program for population PK. Due to time constraints, the latter aspect will be strictly didactic and NOT hands-on. (Instructor: Nancy Sambol)

Logistics for these optional courses

These courses will be held virtually on the afternoon of February 24, 2023 immediately after the Pharmacokinetics for Pharmaceutical Scientists course concludes. It is not possible to register for both the Transporters and the Population-PK courses together because they occur simultaneously with one another. The registration fee for either is $ TBA and includes the syllabus. Enrollment is limited and no on-site registration is available. In the case of cancellations received in writing on or before January 23, 2023 the fee (less, as administrative expenses, $100 per canceled enrollee) will be returned. There will be no refund on cancellations made after that date.  

Sign up for notifications for the 2023 course