Research

CERSI Principal Investigator: Atul Butte, MD, PhD (UCSF)

FDA Collaborators: Barbee Whitaker, PhD (CBER/FDA), Steven Anderson, PhD, MPP (CBER/FDA), Artur Belov, PhD (CBER/FDA), Hui-Lee Wong, PhD (CBER/FDA)

Status: Active

Plain Language Summary

CERSI Principal Investigator: Utkan Demirci, PhD (Stanford)

FDA Collaborators: Indira Hewlett, PhD (CBER/FDA), Mohan Haleyurgirisetty, PhD (CBER/FDA), Jiangqin Zhao, PhD (CBER/FDA)

Status: Active

CERSI Principal Investigator: Ngan Huang, PhD (Stanford)

FDA Collaborators: Kyung Sung, PhD (CBER/FDA)

Status: Active

CERSI Principal Investigators: Vivek Rudrapatna, MD, PhD (UCSF), Atul Butte, MD, PhD (UCSF), Ludwig, Dana, MD (UCSF)

FDA Collaborators: Samer El-Kamary, MD, MPH (CDER/FDA), Jawahar Tiwari, PhD (CBER/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: James Zou, PhD (Stanford)

FDA Collaborators: Steven Anderson, PhD, MPP (CBER/FDA), Barbee Whitaker, PhD (CBER/FDA), Alan Williams, PhD (CBER/FDA), Gregory Pappas, MD, PhD (CBER/FDA), Angela Moy (CBER/FDA)

Status: Completed

CERSI Principal Investigator: Tina Hernandez-Boussard, PhD, MPH, MS (Stanford)

FDA Collaborators: Barbee Whitaker, PhD (CBER/FDA), Steven Anderson, PhD, MPP (CBER/FDA), Artur Belov, PhD (CBER/FDA), Hui-Lee Wong, PhD (CBER/FDA)

Status: Completed

CERSI Principal Investigator: Matthew Porteus, MD, PhD (Stanford)

FDA Collaborators: Zhaohui Ye, PhD (CBER/FDA)

Status: Completed

CERSI Principal Investigator: Eric Kool, PhD (Stanford)

FDA Collaborators: Jaroslav Vostal, MD, PhD (CBER/FDA), Chintamani Atreya,PhD (CBER/FDA)

Status: Completed

CERSI Principal Investigator: Sean Bendall, PhD (Stanford)

FDA Collaborators: Steven Bauer, PhD (CBER/FDA)

Status: Completed

CERSI Principal Investigators: Russ Altman (Stanford)

FDA Collaborators: Liang Zhao (OGD), Meng Hu (OGD)

Status: Active

CERSI Principal Investigators: Sook Wah Yee, PhD (UCSF), Deanna Kroetz, PhD (UCSF) (Co-PI)

FDA Collaborators: Liang Zhao, PhD (CDER/OGD/FDA), Lei Zhang, PhD (CDER/OGD/FDA), Khondoker Alam, PhD (CDER/OGD/FDA)

Status: Active

CERSI Principal Investigator: Katherine Yang, PharmD, MPH (UCSF)

FDA Collaborators: Lei Zhang, PhD (CDER/FDA), Eleftheria Tsakalozou, PhD (CDER/FDA)

Status: Active

CERSI Principal Investigator: Sook Wah Yee, PhD (UCSF)

FDA Collaborators: Shiew Mei Huang, PhD (CDER/FDA), Qi Liu, PhD (CDER/FDA), Lei Zhang, PhD (CDER/FDA)

Status: Active

CERSI Principal Investigator: Laura Esserman, MD, MBA (UCSF)

FDA Collaborators: Mitra Rocca, Dipl Inform Med (CDER/FDA), Jacqueline Corrigan-Curay, JD, MD (CDER/FDA), Dianne Paraoan (CDER/FDA), Frank Weichold, MD, PhD (ORSI/FDA), Paul Kluetz, MD (OCE/FDA), Gideon (Scott) Gordon, PhD (CDER/FDA)

Status: Active

CERSI Principal Investigator: Daniel Rubin, MD, MS (Stanford)

FDA Collaborators: Qi Liu, PhD, MStat, FCP (CDER/FDA), Yaning Wang, PhD, MStat (CDER/FDA), Hao Zhu, PhD, MStat (CDER/FDA), M. Khair ElZarrad PHD, MPH (CDER/FDA), Matthew Diamond, MD, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigators: Kevin Healy, PhD (UC Berkeley), Edward Hsiao, MD, PhD (UCSF)

FDA Collaborators: Alexandre Ribeiro, PhD (CDER/FDA), David Strauss, MD, PhD (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Ida Sim, MD, PhD (UCSF)

FDA Collaborators: Elaine Johanson (OHI/FDA), Ameeta Parekh, PhD (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Steve Goodman, MD, MHS, PhD (Stanford)

FDA Collaborators: Telba Irony, PhD (CBER/FDA), Tom Permutt, PhD (CDER/FDA), Estelle Russek-Cohen, PhD (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Peter Turnbaugh, PhD (UCSF)

FDA Collaborators: Roselie Bright, ScD, MS, PMP (OHI/FDA), Elaine Johanson (OHI/FDA)

Status: Completed

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Sonja Brajovic, MD (CDER/FDA), Todd Bridges, RPh (CDER/FDA), Carol Pamer, RPh, MPH (CDER/FDA), Jim Schlick, RPh, MBA (CDER/FDA), Jo Wyeth, PharmD (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Kathy Giacomini, PhD (UCSF)

FDA Collaborators: Andrew Babiskin, PhD (CDER/FDA), Sruthi King, PhD (CDER/FDA), Zhanglin Ni, PhD (CDER/FDA), Eleftheria Tsakalozou, PhD (CDER/FDA), Liang Zhao, PhD (CDER/FDA), Susan Zuk, MS (CDER/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Brian Shoichet, PhD (UCSF)

FDA Collaborators: Andrew Babiskin, PhD (CDER/FDA), Robert Dorsam, PhD (CDER/FDA), Victoria Keck, MHA (CDER/FDA), Zhanglin Ni, PhD (CDER/FDA), Eleftheria Tsakalozou, PhD (CDER/FDA), Liang Zhao, PhD (CDER/FDA), Susan Zuk, MS (CDER/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Laura Esserman, MD, MBA (UCSF)

FDA Collaborators: Mitra Rocca, Dipl Inform Med (CDER/FDA), Ronald Fitzmartin, PhD, MBA (CDER/FDA), Fatima Frye (CDER/FDA), MaryAnne Slack (CDER/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Nigam Shah, MBBS, PhD (Stanford)

FDA Collaborators: Ruth Barratt, PhD, DVM (CDER/FDA), Henry Francis, MD (CDER/FDA), Ana Szarfman, MD, PhD (CDER/FDA), Isaac Chang, MD, PhD (CDRH/FDA), Joseph Tonning, MD (CDER/FDA), Robert Ball, MD, MPH (CDER/FDA), Mitra Rocca, Dipl Inform Med (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Steve Anderson, PhD, MPP (CBER/FDA), Robert Ball, MD, MPH (CDER/FDA), Ruth Barratt, PhD, DVM (CDER/FDA), Mitra Rocca, Dipl Inform Med (CDER/FDA), Carol Pamer, RPh, MPH (CDER/FDA), Scott Proestel, MD (CDER/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Manisha Desai (Stanford)

FDA Collaborators: Maria Matilde Kam (CDER), Andrew Potter (CDER), Paul Schuette (CDER), Lili Garrard (CDER)

Status: Active

CERSI Principal Investigator: Christopher Almond (Stanford), Chandra Ramamoorthy (Stanford)

FDA Collaborators: Nilsa Loyo-Berrios, PhD (CDRH/FDA), Malvina Eydelman, MD (CDRH/FDA), Rebecca Torguson, MPH (CDRH/FDA), Christine Merenda (OMHHE/FDA), Allison O'Neill, PhD (CDRH/FDA), Gene Pennello, PhD (CDRH/FDA), Rebecca Ward, PhD (CDRH/FDA), Vasum Peiris, MD, (CDRH/FDA), Michelle Tarver, MD, PhD (CDRH/FDA), Damia Jackson (CDRH/FDA)

Status: Active

Plain Language Summary

CERSI Principal Investigator: Philip Bickler, MD (UCSF), Michael Lipnick, MD (UCSF)

FDA Collaborators: Nilsa Loyo-Berrios, PhD (CDRH/OPEQ/OCEA/FDA), Malvina Eydelman, MD (CDRH/OPEQ/OHT1/FDA), Rebecca Torguson, MPH (CDRH/OPEQ/OHT1/FDA), Christine Merenda (OMHHE/FDA)

Status: Active

Plain Language Summary

CERSI Principal Investigator: Andrew Auerbach, MD (UCSF)

FDA Collaborators: Leeda Rashid, MD, MPH (CDRH/FDA), Anindita Saha, (CDRH/FDA), Bakul Patel, MS, MBA (CDRH/FDA), Cathy Bahr (CDRH/FDA), Vinay Pai, PhD (CDRH/FDA), Arti Tandon, PhD (CDRH/FDA), JiPing Chen, MD, PhD (CDRH/FDA), Charles Yongpravat (CDRH/FDA), Aubrey Shick, MS (CDRH/FDA)

Status: Active

CERSI Principal Investigator: Jean Feng, PhD (UCSF)

FDA Collaborators: Berkman Sahiner, PhD (CDRH/FDA), Alexej Gossmann, PhD, CDRH/FDA)

Status: Active

CERSI Principal Investigator: Shuvo Roy, PhD (UCSF)

FDA Collaborators: Qijin Lu, PhD (CDRH/FDA), Megan Jamiolkowski, PhD (CDRH/FDA), Richard Malinauskas, PhD (CDRH/FDA)

Status: Active

CERSI Principal Investigator: Nigam Shah, MBBS, PhD (Stanford)

FDA Collaborators: Anindita Saha (CDRH/FDA), Bakul Patel, MS, MBA (CDRH/FDA), MiRa Jacobs, PhD (CDRH/FDA), Vinay Pai, PhD (CDRH/FDA), Aubrey Shick, MS (CDRH/FDA), Gloria Nyankima, PhD, (CDRH/FDA), Jessica Paulsen (CDRH/FDA), Kan Fang, MD (CDRH/FDA),,Charlie Yongpravat (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Sanket Dhruva, MD, MHS (UCSF)

FDA Collaborators: Hetal Odobasic, MS (CDRH/FDA), Li Wang, PhD, MBA, MS (CDRH/FDA), Jacqueline M. Major, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Jeffrey Lotz, PhD (UCSF)

FDA Collaborators: Anton Dmitriev, PhD (CDRH/FDA), Andrew Baumann, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Xiao Hu, PhD (UCSF)

FDA Collaborators: Christopher Scully, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Andrew Auerbach, MD (UCSF)

FDA Collaborators: Bakul Patel, MS, MBA (CDRH/FDA), Vinay Pai, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Jeffrey Lotz, PhD (UCSF)

FDA Collaborators: Anton Dmitriev, PhD (CDRH/FDA), Srinidhi Nagaraja, PhD (CDRH/FDA), Jonathan Peck, MS (CDRH/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Sean Mackey, MD, PhD (Stanford)

FDA Collaborators: Fraser Bocell, PhD (CDRH/OST/FDA), Michelle Tarver, MD, PhD (CDRH/FDA), Allen Chen, PhD (CDRH/FDA)

Status: Active

CERSI Principal Investigator: Sean Mackey, MD, PhD (Stanford)

FDA Collaborators: Michelle Tarver, MD, PhD (CDRH/FDA), Anindita Saha (CDRH/FDA), David Gebben, PhD (CDRH/FDA), Heather Benz, PhD (CDRH/FDA)

Status: Active

CERSI Principal Investigator: Christopher Almond, MD, MPH (Stanford)

FDA Collaborators: Fraser Bocell, PhD (CDRH/FDA), Vasum Peiris, MD, MPH (CDRH/FDA), Michelle Tarver, MD, PhD (CDRH/FDA), Brittany Caldwell, PhD (CDRH/FDA), Anindita Saha (CDRH/FDA), Martin Ho, MSc (CDRH/FDA)

Status: Active

CERSI Principal Investigator: Kuldev Singh, MD, MBA (Stanford)

FDA Collaborators: Malvina Eydelman, MD (CDRH/FDA) Michelle Tarver, MD, PhD (CDRH/FDA)

Status: Active

Plain Language Summary

CERSI Principal Investigator: Geoffrey Sonn, MD (Stanford)

FDA Collaborators: Charles Viviano, MD, PhD (CDRH/FDA), David Gebben, PhD (CDRH/FDA), Olufemi Babalola, MSc, MHS (CDRH/FDA)

Status: Complete

CERSI Principal Investigator: Courtney Lyles, PhD (UCSF), Urmimala Sarkar, MD, MPH (UCSF)

FDA Collaborators: Fraser Bocell, PhD (CDRH/FDA), Michelle Tarver, MD PhD (CDRH/FDA), Brittany Caldwell, PhD (CDRH/FDA), Annie Saha (CDRH/FDA), Martin Ho, MSc (CDRH/FDA)

Status: Complete

CERSI Principal Investigator: Korey Hood, PhD (Stanford)

FDA Collaborators: Heather Benz, PhD (CDRH/FDA), Martin Ho, MSc (CDRH/FDA), Vasum Peiris, MD, MPH (CDRH/FDA), Anindita Saha (CDRH/FDA)

Status: Complete

CERSI Principal Investigator: Leslie Wilson, PhD (UCSF)

FDA Collaborators: Eugene Civillico, PhD (CDRH/FDA), Telba Irony, PhD (CBER/FDA), Xuefeng Li, PhD (CDRH/FDA), Anindita Saha (CDRH/FDA)

Status: Complete

Plain Language Summary

CERSI Principal Investigator: Elad Ziv, MD (UCSF)

FDA Collaborators: Marc Theoret (OCE/FDA), Julie Schneider (OCE/FDA), Wenming Xiao (CDER/FDA), Maitreyee Hazarika (CDER/FDA)

Status: Active

CERSI Principal Investigator: Joseph Wu, MD, PhD (Stanford)

FDA Collaborators: Laleh Amiri-Kordestani (CDER/FDA), Kevin Ford (CDER/FDA), Margret Merino (CDER/FDA) , Julie Schneider (OCE/FDA)

Status: Active

CERSI Principal Investigator: Joseph Wu, MD, PhD (Stanford)

FDA Collaborators: David Strauss (CDER/FDA), Kevin Ford (CDER/FDA), Dylan Bruckner (CDER/FDA)

Status: Active

CERSI Principal Investigator: Joseph Wu, PhD (Stanford)

FDA Collaborators: David Strauss, MD, PhD (CDER/OTS/OCP/FDA), Alexandre Ribeiro, PhD (CDER/FDA), Rodney Rouse, DVM (CDER/OTS/OCP/FDA), Kevin Ford, PhD (CDER/FDA)

Status: Active

CERSI Principal Investigator: Joseph Wu, MD, PhD (Stanford)

FDA Collaborators: Bridget Nugent, PhD (OWH/FDA), Alexandre Ribeiro, PhD (CDER/DARS/FDA)

Status: Active

CERSI Principal Investigator: Charles Chiu, MD, PhD (UCSF)

FDA Collaborators: Indira Hewlett, PhD (CBER/FDA)

Status: Active

CERSI Principal Investigator: Snehit Prabhu, PhD (Stanford)

FDA Collaborators: Elaine Johanson (OHI/FDA), Zivana Tezak, PhD (CDRH/FDA), Richardae Araojo, PharmD (OMHHE/FDA), Christine Lee, PharmD, PhD (OMHHE/FDA)

Status: Active

CERSI Principal Investigator: Snehit Prabhu, PhD (Stanford)

FDA Collaborators: Elaine Johanson (OHI/FDA), Zivana Tezak, PhD (CDRH/FDA), Richardae Araojo, PharmD (OMHHE/FDA), Christine Lee, PharmD, PhD (OMHHE/FDA)

Status: Active

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Michael Pacanowski, PharmD, MPH (CDER/FDA), Oluseyi Adeniyi, PhD (CDER/FDA), Paula Hyland, PhD (CDER/FDA), Ellis Christopher, PhD (CDER/FDA), Rosane Charlab Orbach, PhD (CDER/FDA), Robert Schuck, PhD (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Michael Pacanowski, PharmD, MPH (CDER/FDA), Anuradha Ramamoorthy, PhD (CDER/FDA), Oluseyi Adeniyi, PhD (CDER/FDA)

Status: Completed

CERSI Principal Investigator: Dmitri Petrov, PhD (Stanford)

FDA Collaborators: Elaine Johanson (OHI/FDA)

Status: Completed

CERSI Principal Investigator: Snehit Prabhu, PhD (Stanford)

FDA Collaborators: Adam Berger, PhD (CDRH/FDA), Roselie Bright, ScD, MS, PMP (OHI/FDA), Elaine Johanson (OHI/FDA), Samir Lababidi, PhD (OHI/FDA), David Litwack, PhD (CDRH/FDA), Zivana Tezak, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Roselie Bright, ScD (OHI/FDA), Larry Callahan, PhD (OHI/FDA), Elaine Johanson (OHI/FDA), Frank Switzer, PhD (OHI/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Elaine Johanson (OHI/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Janice Schwartz, MD (UCSF)

FDA Collaborators: Christine Lee, PharmD, PhD (OMHHE/FDA), Qi Liu, PhD, MStat (CDER/OCP/FDA)

Status: Active

CERSI Principal Investigator: Janice Schwartz, MD (UCSF)

FDA Collaborators: Qi Liu, PhD, MStat (CDER/OCP/FDA), Shiew-Mei Huang, PhD (CDER/OCP/OTS/FDA)

Status: Active

CERSI Principal Investigator: Timothy Meyer, MD (Stanford)

FDA Collaborators: Shiew Mei Huang, PhD (CDER/FDA), Lei Zhang, PhD (CDER/FDA), Qi Liu, PhD (CDER/FDA)

Status: Active

CERSI Principal Investigator: Christopher Almond, MD, MPH (Stanford)

FDA Collaborators: Vasum Peiris, MD, MPH (CDRH/FDA), Brittany Caldwell, PhD (CDRH/FDA)

Status: Active

CERSI Principal Investigator: Sook Wah Yee, PhD (UCSF)

FDA Collaborators: Shiew Mei Huang, PhD (CDER/FDA), Lei Zhang, PhD (CDER/FDA)

Status: Active

CERSI Principal Investigator: Lee Sanders, MD (Stanford), Bonnie Halpern-Felsher, PhD (Stanford)

FDA Collaborators: Christine Lee, PharmD, PhD (OMHHE/FDA), Richardae Araojo, PharmD, MS (OMHHE/FDA), Shelly Harris, MPH (CDER/FDA), Grace Jones, PharmD (CDER/FDA), Martin Mendoza, PhD (OMHHE/FDA), Amanda Pike-McCrudden, MAA (CDER/FDA), Lee Zwanziger (OC/FDA)

Status: Active

CERSI Principal Investigator: Urmimala Sarkar, MD, MPH (UCSF), Courtney Lyles, PhD (UCSF)

FDA Collaborators: Richardae Araojo, PharmD, MS (OMHHE/FDA), Christine Lee, PharmD, PhD (OMHHE/FDA), Michelle Tarver, MD, PhD (CDRH/FDA)

Status: Completed

CERSI Principal Investigator: Esteban Burchard, MD, MPH (UCSF)

FDA Collaborators: Richardae Araojo, PharmD (OMHHE/FDA)

Status: Completed

CERSI Principal Investigator: Russ Altman, MD, PhD (Stanford)

FDA Collaborators: Bridget Nugent, PhD (OWH/FDA), Susan Bersoff-Matcha, MD (OWH/FDA), Patricia Bradfield (OWH/FDA), Kaveeta Vasisht, MD, PharmD (OWH/FDA), Ryan Conville (OWH/FDA), Jonathan Kwan, MS (OTP/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Kathy Giacomini, PhD (UCSF), Timothy Meyer, MD (Stanford)

FDA Collaborators: Ruth Barratt, PhD, DVM (CDER/FDA), Lei Zhang, PhD (CDER/FDA), Shiew Mei Huang, PhD (CDER/FDA), Issam Zineh, PharmD, MPH (CDER/FDA), Ming-Liang Tan, PhD (CDER/FDA)

Status: Completed

Plain Language Summary

CERSI Principal Investigator: Atul Butte, MD, PhD (UCSF), Kendra Radtke, PharmD, PhD (UCSF)

FDA Collaborators: Steven Anderson (CBER/FDA), Yun Lu (CBER/FDA), Artur Belov (CBER/FDA), Barbee Whitaker (CBER/FDA), Richard Forshee (CBER/FDA), Angela Moy (CBER/FDA), Chartrina Andrell (CBER/FDA),

Status: Active

CERSI Principal Investigator: Atul Butte, MD, PhD (UCSF)

FDA Collaborators: Barbee Whitaker, PhD (CBER/OBE/FDA), Artur Belov, PhD (CBER/OBE/FDA), Hussein Ezzeldin, PhD (CBER/OBE/FDA), Steve Anderson, PhD (CBER/OBE/FDA), Jane Mutanga, PhD (CBER/FDA)

Status: Active

CERSI Principal Investigator: Rohit Vashisht, PhD (UCSF)

FDA Collaborators: Bridget Nugent, PhD (OWH/FDA), Kaveeta Vasisht, MD, PharmD (OWH/FDA), Susan Bersoff-Matcha, MD (OWH/FDA), Osman Yogurtcu, PhD (CBER/FDA), Yong Ma, PhD (CDER/FDA), Andrew Giffin, PhD (CDER/FDA) , Shuang (Sarah) Zhou, PhD (CDER/FDA)

Status: Active

Plain Language Summary

CERSI Principal Investigator: Laura Esserman, MD, MBA (UCSF)

FDA Collaborators: Mitra Rocca, Dipl. Inform. Med. (CDER/FDA), Jacqueline Corrigan-Curay, JD, MD (CDER/FDA), Dianne Paraoan (CDER/FDA), Vishal Bhatnagar, MD (OCE/FDA), Frank Weichold, MD, PhD (ORSI/FDA)

Status: Active

CERSI Principal Investigator: Laura Esserman, MD, MBA (UCSF)

FDA Collaborators: Mitra Rocca, Dipl. Inform. Med. (CDER/FDA), Jacqueline Corrigan-Curay, JD, MD (CDER/FDA), Dianne Paraoan (CDER/FDA), Vishal Bhatnagar, MD (OCE/FDA), Frank Weichold, MD, PhD (ORSI/FDA)

Status: Active

CERSI Principal Investigator: Atul Butte, MD, PhD (UCSF)

FDA Collaborators: Amy Abernethy, MD, PhD (OC/FDA)

Status: Completed

2024 May 10

Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters

Pharmaceutics

Authors: Kulkarni CP, Yang J, Koleske ML, Lara G, Alam K, Raw A, Rege B, Zhao L, Lu D, Zhang L, Yu LX, Lionberger RA, Giacomini KM, Kroetz DL, Yee SW

PMID 38794309

2024 Mar 14

Attitudes on participation in clinical drug trials: A nationally representative survey of older adults with multimorbidity

Journal of the American Geriatrics Society

Authors: Schwartz JB, Liu RY, Boscardin J, Liu Q, Lau SWJ, Khatri S, Tarn D

PMID 38485469

2024 Mar 8

Algorithmic Identification of Treatment-Emergent Adverse Events From Clinical Notes Using Large Language Models: A Pilot Study in Inflammatory Bowel Disease

Clinical Pharmacology & Therapeutics

Authors: Silverman AL, Sushil M, Bhasuran B, Ludwig D, Buchanan J, Racz R, Parakala M, El-Kamary S, Ahima O, Belov A, Choi L, Billings M, Li Y, Habal N, Liu Q, Tiwari J, Butte AJ, Rudrapatna VA

PMID 38459719

2024 Mar

Characterisation of digital therapeutic clinical trials: a systematic review with natural language processing

The Lancet Digital Health

Authors: Miao BY, Sushil M, Xu A, Wang M, Arneson D, Berkley E, Subash M, Vashisht R, Rudrapatna V, Butte AJ

PMID 38395542

2024 Feb 6

A comparative study of zero-shot inference with large language models and supervised modeling in breast cancer pathology classification

Research Square

Authors: Sushil M, Zack T, Mandair D, Zheng Z, Wali A, Yu YN, Quan Y, Butte AJ

PMID 38405831

2024 Jan 5

Extracorporeal Life Support Organization (ELSO) Member Centers Group

Artificial Organ Research and Development ASAIO Journal

Authors: Tonna JE, Boonstra PS, MacLaren G, Paden M, Brodie D, Anders M, Hoskote A, Ramanathan K, Hyslop R, Fanning JJ, Rycus P, Stead C, Barrett NA, Mueller T, Gómez RD, Malhotra Kapoor P, Fraser JF, Bartlett RH, Alexander PMA, Barbaro RP

PMID 38181413

2023 November 11

Trends in Influenza Vaccination Rates among a Medicaid Population from 2016 to 2021

Vaccines (Basel)

Authors: Naderalvojoud B, Shah ND, Mutanga JN, Belov A, Staiger R, Chen JH, Whitaker B, Hernandez-Boussard T

PMID 38006044

2023 October 26

Tisagenlecleucel utilisation and outcomes across refractory, first relapse and multiply relapsed B-cell acute lymphoblastic leukemia: a retrospective analysis of real-world patterns

eClinicalMedicine

Authors: Barsan V, Li Y, Prabhu S, Baggott C, Nguyen K, Pacenta H, Phillips CL, Rossoff J, Stefanski H, Talano JA, Moskop A, Baumeister S, Verneris MR, Myers GD, Karras NA, Cooper S, Qayed M, Hermiston M, Satwani P, Krupski C, Keating A, Fabrizio V, Chinnabhandar V, Kunicki M, Curran KJ, Mackall CL, Laetsch TW, Schultz LM

PMID 37954907

2023 July 29

Extracellular Matrix Bioactive Molecules and Cell Behavior Modeling

Handbook of the Extracellular Matrix

Authors: Khanna A, Oropeza BP, Jain I, Huang NF

(Project #32)

2023 June 27

HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL

Blood Advances

Authors: McNerney KO, Si Lim SJ, Ishikawa K, Dreyzin A, Vatsayan A, Chen JJ, Baggott C, Prabhu S, Pacenta HL, Philips C, Rossoff J, Stefanski HE, Talano JA, Moskop A, Verneris M, Myers D, Karras NA, Brown P, Bonifant CL, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Baumeister SHC, Fabrizio VA, Chinnabhandar V, Egeler E, Mavroukakis S, Curran KJ, Mackall CL, Laetsch TW, Schultz LM

PMID 36857419

(Project #43)

2023 June 6

Virtual Reality for Chronic Pain Management Among Historically Marginalized Populations: Systematic Review of Usability Studies

Journal of Medical Internet Research

Authors: Dy M, Olazo K, Lisker S, Brown E, Saha A, Weinberg J, Sarkar U

PMID 37279039

(Project #52)

2023 June 1

Realizing Potential: Pediatric Extracorporeal Membrane Oxygenation Needs Common Adverse Event Definitions to Improve Outcomes

Pediatric Critical Care Medicine

Authors: Alexander PMA, Habet V, Barbaro RP

PMID 37260339

2023 May 29

Novel computational methods on electronic health record yields new estimates of transfusion-associated circulatory overload in populations enriched with high-risk patients

Transfusion (Online ahead of print)

Authors: Wang M, Goldgof GM, Patel A, Whitaker B, Belov A, Chan B, Phelps E, Rubin B, Anderson S, Butte AJ

PMID 37248741

(Project #41)

2023 February 10

Real-world utilization of SARS-CoV-2 serological testing in RNA positive patients across the United States

PLoS One

Authors: Rodriguez-Watson CV, Sheils NE, Louder AM, Eldridge EH, Lin ND, Pollock BD, Gatz JL, Grannis SJ, Vashisht R, Ghauri K, Valo G, Chakravarty AG, Lasky T, Jung M, Lovell SL, Major JM, Kabelac C, Knepper C, Leonard S, Embi PJ, Jenkinson WG, Klesh R, Garner OB, Patel A, Dahm L, Barin A, Cooper DM, Andriola T, Byington CL, Crews BO, Butte AJ, Allen J

PMID 36763574

(Project #53)

2023 February 3

Real-world performance of SARS-Cov-2 serology tests in the United States, 2020

PLoS One

Authors: Rodriguez-Watson CV, Louder AM, Kabelac C, Frederick CM, Sheils NE, Eldridge EH, Lin ND, Pollock BD, Gatz JL, Grannis SJ, Vashisht R, Ghauri K, Knepper C, Leonard S, Embi PJ, Jenkinson G, Klesh R, Garner OB, Patel A, Dahm L, Barin A, Cooper DM, Andriola T, Byington CL, Crews BO, Butte AJ, Allen J

PMID 36735683

(Project #53)

2022 December 28

Cardiovascular implantable electronic device lead safety: Harnessing real-world remote monitoring data for medical device evaluation

Heart Rhythm

Authors: Caughron H, Bowman H, Raitt MH, Whooley MA, Tarasovsky G, Shen H, Matheny ME, Selzman KA, Wang L, Major J, Odobasic H, Dhruva SS

PMID 36586706

(Project #59)

2022 October 9

From Genes to Geography, from Cells to Community, from Biomolecules to Behaviors: The Importance of Social Determinants of Health

Biomolecules

Authors: Davidson J, Vashisht R, Butte AJ

PMID 36291658

(Project #53, #68)

2022 August 4

Technical Applications of Microelectrode Array and Patch Clamp Recordings on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Journal of Visualized Experiments

Authors: Zhao SR, Mondéjar-Parreño G, Li D, Shen M, Wu JC

PMID 35993757

(Project #62)

2022 June 6

I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations

BMJ Open

Authors: Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD

PMID 35667714

(Project #55)

2022 April 19

Analyzing real world data of blood transfusion adverse events: Opportunities and challenges

Transfusion

Authors: Jhaveri P, Bozkurt S, Moyal A, Belov A, Anderson S, Shan H, Whitaker B, Hernandez-Boussard T

PMID 35437749

(Project #38)

2022 March 1

Preventive drugs for Huntington's disease: A choice-based conjoint survey of patient preferences

Journal of Clinical and Translational Science

Authors: Parrish MC, Hanson-Kahn A, Srinivasan V, Grimes KV

PMID 35433035

2022 January 28

High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3

Pharmaceutical Research (Online ahead of print)

Authors: Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM

PMID 35089508

(Project #23)

2022 January 25

Tisagenlecleucel outcomes in relapsed/refractory extramedullary ALL: a Pediatric Real World CAR Consortium Report

Blood Advances, Volume 6, Issue 2, pp. 600-610

Authors: Fabrizio VA, Phillips CL, Lane A, Baggott C, Prabhu S, Egeler E, Mavroukakis S, Pacenta H, Rossoff J, Stefanski HE, Talano JA, Moskop A, Margossian SP, Verneris MR, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Chinnabhandar V, Kunicki M, Goksenin AY, Curran KJ, Mackall CL, Laetsch TW, Schultz LM

PMID 34794180

(Project #43)

2022 January 15

Do patient-reported outcome measures measure up? A qualitative study to examine perceptions and experiences with heart failure proms among diverse, low-income patients

Journal of Patient-Reported Outcomes, Volume 6, Issue 1, Article 6 (pp. 1-12)

Authors: Davis J, Olazo K, Sierra M, Tarver ME, Caldwell B, Saha A, Lisker S, Lyles C, Sarkar U

PMID 35032226

(Project #28)

2022 January 11

Bayesian logistic regression for online recalibration and revision of risk prediction models with performance guarantees

Journal of the American Medical Informatics Association (Online ahead of print)

Authors: Feng J, Gossmann A, Sahiner B, Pirracchio R

PMID 35022756

(Project #58)

2021 December 09

Disease Burden Affects Outcomes in Pediatric and Young Adult B-Cell Lymphoblastic Leukemia After Commercial Tisagenlecleucel: A Pediatric Real-World Chimeric Antigen Receptor Consortium Report

Journal of Clinical Oncology (Online ahead of print)

Authors: Schultz LM, Baggott C, Prabhu S, Pacenta HL, Phillips CL, Rossoff J, Stefanski HE, Talano JA, Moskop A, Margossian SP, Verneris MR, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Fabrizio VA, Rouce RH, Chinnabhandar V, Kunicki M, Barsan VV, Goksenin AY, Li Y, Mavroukakis S, Egeler E, Curran KJ, Mackall CL, Laetsch TW

PMID 34882493

(Project #43)

2021 November 25

Out-of-specification tisagenlecleucel does not compromise safety or efficacy in pediatric acute lymphoblastic leukemia

Blood, Volume 138, Issue 21, pp. 2138-2142

Authors: Rossoff J, Baggott C, Prabhu S, Pacenta H, Phillips CL, Stefanski H, Talano JA, Moskop A, Margossian SP, Verneris MR, Myers GD, Karras N, Brown PA, Qayed M, Hermiston M, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Fabrizio VA, Kunicki M, Chinnabhandar V, Goksenin AY, Curran KJ, Mackall CL, Laetsch TW, Schultz LM

PMID 34499715

(Project #43)

2021 November 17

Optimal fludarabine lymphodepletion is associated with improved outcomes following CAR T-cell Therapy

Blood Advances (Online ahead of print)

Authors: Fabrizio VA, Boelens JJ, Mauguen A, Baggott C, Prabhu S, Egeler E, Mavroukakis S, Pacenta HL, Phillips CL, Rossoff J, Stefanski H, Talano JA, Moskop A, Margossian SP, Verneris MR, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston ML, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Chinnabhandar V, Kunicki M, Goksenin AY, Mackall CL, Laetsch TW, Schultz LM, Curran KJ

PMID 34788386

(Project #43)

2021 September 22

Barriers and Facilitators to the Implementation of Virtual Reality as a Pain Management Modality in Academic, Community, and Safety-Net Settings: Qualitative Analysis

Journal of Medical Internet Research, Volume 23, Issue 9, Article 26623 (pp. 1-9)

Authors: Sarkar U, Lee JE, Nguyen KH, Lisker S, Lyles CR

PMID 34550074

(Project #52)

2021 September 21

U.S. Food and Drug Administration Reasoning in Approval Decisions When Efficacy Evidence Is Borderline, 2013-2018

Annals of Internal Medicine, Volume 174, Issue 11, pp. 1603-1611

Authors: Janiaud P, Irony T, Russek-Cohen E, Goodman SN

PMID 34543584

(Project #21)

2021 September 16

Racial/ethnic differences in eligibility for asthma biologics among pediatric populations

Journal of Allergy and Clinical Immunology, Volume 148, Issue 5, pp. 1324-1331.e12

Authors: Wohlford EM, Huang PF, Elhawary JR, Millette LA, Contreras MG, Witonsky J, Holweg CTJ, Oh SS, Lee C, Merenda C, Rabin RL, Araojo R, Mak ACY, Eng CS, Hu D, Huntsman S, LeNoir MA, Rodríguez-Santana JR, Borrell LN, Burchard EG

PMID 34536416

(Project #46)

2021 September 15

Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein

American Association of Pharmaceutical Scientists (AAPS) Journal, Volume 23, Issue 5, Article 106 (pp. 1-12)

Authors: Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL

PMID 34528148

(Project #15B)

2021 July 24

ACVR1 R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages

Bone, Volume 153, Article 116129 (pp. 1-15)

Authors: Matsuo K, Lepinski A, Chavez RD, Barruet E, Pereira A, Moody TA, Ton AN, Sharma A, Hellman J, Tomoda K, Nakamura MC, Hsiao EC

PMID 34311122

(Project #31)

2021 July 18

Genomewide Association Studies in Pharmacogenomics

Clinical Pharmacology & Therapeutics, Volume 110, Issue 3, pp. 637-648

Authors: McInnes G, Yee SW, Pershad Y, Altman RB

PMID 34185318

(Project #36)

2021 June 17

Technical considerations for evaluating clinical prediction indices: a case study for predicting code blue events with MEWS

Physiological Measurement, Volume 42, Issue 5, Article 055005 (pp. 1-17)

Authors: Gadhoumi K, Beltran A, Scully CG, Xiao R, Nahmias DO, Hu X

PMID 33902012

(Project #34)

2021 May 03

Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data

Clinical Pharmacology & Therapeutics, Volume 110, Issue 1, pp. 108-122

Authors: Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM

PMID 33759449

2021 April 30

Engineering Hydrogel-Based Biomedical Photonics: Design, Fabrication, and Applications

Advanced Materials, Volume 33, Issue 23, Article 2006582 (pp. 1-25)

Authors: Guimarães CF, Ahmed R, Marques AP, Reis RL, Demirci U

PMID 33929771

(Project #33)

2021 April 20

Engineering Cardiovascular Tissue Chips for Disease Modeling and Drug Screening Applications

Frontiers in Bioengineering and Biotechnology

Authors: Chan AHP, Huang NF

PMID 33959600

(Project #32)

2021 April 11

Vision-Targeted Health-Related Quality-of-Life Survey for Evaluating Minimally Invasive Glaucoma Surgery

American Journal of Ophthalmology, Volume 229, pp. 145-151

Authors: Cui QN, Hays RD, Tarver ME, Spaeth GL, Paz SH, Weidmer B, Fellman RL, Vold SD, Eydelman M, Singh K

PMID 33852908

(Project #14)

2021 April

How medical AI devices are evaluated: limitations and recommendations from an analysis of FDA approvals

Nature Medicine, Volume 27, Issue 4, pp. 582-584

Authors: Wu E, Wu K, Daneshjou R, Ouyang D, Ho DE, Zou J

PMID 33820998

(Project #39)

2021 February 28

A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring

Journal of the American Medical Informatics Association, Volume 109, Issue 5, 1197-1202

Authors: Han L, Ball R, Pamer CA, Altman RB, Proestel S

PMID 33492663

(Project #1)

2020 September 07

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3

Journal of Pharmaceutical Sciences, Volume 110, Issue 1, pp. 347-353

Authors: Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM

PMID 32910949

(Project #3)

2020 July 29

Scientific Considerations for Global Drug Development

Science Translational Medicine, Vol 12, Issue 554, Article eaax2550 (pp. 1-5)

Authors: Ling Zou, Jennifer L Wilson, Kit Wun Kathy Cheung, Lawrence Lin, Elizabeth A E Green, Analia I Porras, Ling Zou, David Mukanga, Paul A Akpa, Delese Mimi Darko, Rae Yuan, Sheng Ding, Wiltshire C N Johnson, Howard A Lee, Emer Cooke, Carl C Peck, Steven E Kern, Dan Hartman, Yoshikazu Hayashi, Peter W Marks, Russ B Altman, Murray M Lumpkin, Kathleen M Giacomini, Terrence F Blaschke

PMID 32727913

2020 July 24

The Activities of Drug Inactive Ingredients on Biological Targets

Science, Vol. 369, Issue 6502, pp. 403-413

Authors: Joshua Pottel, Duncan Armstrong, Ling Zou, Alexander Fekete, Xi-Ping Huang, Hayarpi Torosyan, Dallas Bednarczyk, Steven Whitebread, Barun Bhhatarai, Guiqing Liang, Hong Jin, Nassir Ghaemi, Samuel Slocum, Katalin V. Lukacs, John J. Irwin, Ellen L. Berg, Kathleen M. Giacomini, Bryan L. Roth, Brian K. Shoichet, Laszlo Urban

PMID 32703874

(Project #15A)

2020 July 03

Effects of Nicotine on the Translation of Stem Cell Therapy

Regenerative Medicine, Volume 15, Issue 5, pp. 1679-1688

Authors: Chan AH, Huang NF

PMID 32618492

(Project #32)

2020 June 22

Bacterial Metabolism Rescues the Inhibition of Intestinal Drug Absorption by Food and Drug Additives

Proceedings of the National Academy of Sciences, Volume 117, Issue 27, pp. 16009-16018

Authors: Ling Zou, Peter Spanogiannopoulos, Lindsey M Pieper, Huan-Chieh Chien, Wenlong Cai, Natalia Khuri, Joshua Pottel, Bianca Vora, Zhanglin Ni, Eleftheria Tsakalozou, Wenjun Zhang, Brian K Shoichet, Kathleen M Giacomini, Peter J Turnbaugh

PMID 32571913

(Project #15B)

2020 May 27

Extracting Chemical Reactions from Text using Snorkel

BMC (BioMed Central) Bioinformatics 2020, Volume 21, Issue 1, Article 217 (pp. 1-15)

Authors: Mallory EK, de Rochemonteix M, Ratner A, Acharya A, Re C, Bright RA, Altman RB

PMID 32460703

(Project #16B)

2020 February 10

Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP

Molecular Pharmaceutics, Volume 17, Issue 3, pp. 748-756

Authors: Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM

PMID 31990564

(Project #15B)

2019 December

Advancing the Use of Patient Preference Information as Scientific Evidence in Medical Product Evaluation: A Summary Report of the Patient Preference Workshop

Patient, Volume 12, Issue 6, pp. 553-557

Authors: Benz HL, Lee TJ, Tsai JH, Bridges JFP, Eggers S, Moncur M, Shaya FT, Shoulson I, Spatz ES, Wilson L, Saha A

PMID 31696436

(Project #17)

2019 November 26

Patient-Reported Outcomes Measures and Patient Preferences for Minimally Invasive Glaucoma Surgical Devices

Eye, Volume 34, Issue 1, pp. 205-210

Authors: Tianjing Li, T. Le, Ronald D. Hays, Qi N. Cui, Malvina Eydelman, George Spaeth, Michelle E. Tarver & Kuldev Singh

PMID 31772384

(Project #14)

2019 November 23

The Patient Perspective: Putting the Patient at the Center of the Translational Innovation Process

Clinical Pharmacology & Therapeutics, Volume 107, Issue 1, pp. 82-84

Authors: Wilson L, Lin L, Singh K.

PMID 31758800

(Project #14, 17)

2019 November 01

PathFXweb: A Web Application for Identifying Drug Safety and Efficacy Phenotypes

Bioinformatics, Volume 35, Issue 21, pp. 4504–4506​

Authors: Jennifer L Wilson, Mike Wong, Ajinkya Chalke, Nicholas Stepanov, Dragutin Petkovic, Russ B Altman

PMID 31114840

(Project #24)

2019 September

Incorporating Ontogeny in Physiologically Based Pharmacokinetic Modeling to Improve Pediatric Drug Development: What We Know About Developmental Changes in Membrane Transporters

The Journal of Clinical Pharmacology, Volume 59, Issue S1, pp. S56-S69

Authors: Cheung KWK, van Groen BD, Burckart GJ, Zhang L, de Wildt SN, Huang SM

PMID 31502692

(Project #23)

2019 July 03

A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization

Clinical Pharmacology & Therapeutics, Volume 106, Issue 5, pp. 1083-1092

Authors: Cheung KWK, van Groen BD, Spaans E, van Borselen MD, de Bruijn ACJM, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN

PMID 31127606

(Project #23)

2019 June 20

An Overview of Genomic Biomarker Use in Cardiovascular Disease Clinical Trials

Clinical Pharmacology & Therapeutics, Volume 106, Issue 4, pp. 841-846

Authors: Adeniyi O, Ramamoorthy A, Schuck R, Sun J, Wilson J, Zineh I, Pacanowski M

PMID 31002380

(Project #24)

2019 June 10

In Vitro Models for Thrombogenicity Testing of Blood-Recirculating Medical Devices

Expert Review of Medical Devices, Volume 16, Issue 7, pp. 603-616

Authors: Sarode DN, Roy S

PMID 31154869

(Project #25)

2019 February 17

Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation

Clinical Pharmacology & Therapeutics, Volume 105, Issue 4, pp. 815-818

Authors: Kathleen M. Giacomini, Lawrence Lin, Russ B. Altman

PMID 30773618

2019 January 20

Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters

Clinical Pharmacology & Therapeutics, Volume 105, Issue 2, pp. 323-325

Authors: Ling Zou, Zhanglin Ni, Eleftheria Tsakalozou, Kathleen M. Giacomini

PMID 30663035

(Project #15B)

2018 December 07

PathFX Provides Mechanistic Insights into Drug Efficacy and Safety for Regulatory Review and Therapeutic Development

PLOS (Public Library of Science) Computational Biology, Volume 14, Issue 12, Article e1006614 (pp. 1-27)

Authors: Jennifer L. Wilson, Rebecca Racz, Tianyun Liu, Oluseyi Adeniyi, Jielin Sun, Anuradha Ramamoorthy, Michael Pacanowski, Russ Altman

PMID 30532240

(Project #24)

2018 September 27

Data mining of digitized health records in a resource-constrained setting reveals that timely immunophenotyping is associated with improved breast cancer outcomes

BMC (BioMed Central) Cancer, Volume 18, Issue 1, Article 933 (pp. 1-10)

Authors: López-Pineda A, Rodríguez-Moran MF, Álvarez-Aguilar C, Fuentes Valle SM, Acosta-Rosales R, Bhatt AS, Sheth SN, Bustamante CD

PMID 30261931

(Project #16E)

2018 September 12

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries

Annual Review of Pharmacology and Toxicology, Volume 59, pp. 405-421

Authors: Parrish MC, Tan YJ, Grimes KV, Mochly-Rosen D

PMID 30208282

2018 August 06

Network Enhancement as a General Method to Denoise Weighted Biological Networks

Nature Communications, Volume 9, Issue 1, Article 3108 (pp. 1-8)

Authors: Wang B, Pourshafeie A, Zitnik M, Zhu J, Bustamante CD, Batzoglou S, Leskovec J

PMID 30082777

(Project #16E)

2018 May 08

Machine Learning in Chemoinformatics and Drug Discovery

Drug Discovery Today, Volume 23, Issue 8, pp. 1538-1546

Authors: Lo YC, Rensi SE, Torng W, Altman RB

PMID 29750902

2018 May 01

Pharmacogenomics and big genomic data: from lab to clinic and back again

Human Molecular Genetics, Volume 27, Issue R1, pp. R72-R78

Authors: Lavertu A, McInnes G, Daneshjou R, Whirl-Carrillo M, Klein TE, Altman RB

PMID 29635477

2018 January 27

Chemical Reaction Vector Embeddings: Towards Predicting Drug Metabolism in the Human Gut Microbiome

Pacific Symposium of Biocomputing, Volume 23, pp. 56-67

Authors: Mallory EK, Acharya A, Rensi SE, Turnbaugh PJ, Bright RA, Altman RB

PMID 29218869

(Project #16B, 20)

2017 December 03

Biomarkers: Delivering on the Expectation of Molecularly Driven, Quantitative Health

Experimental Biology Medicine, Volume 243, Issue 3, pp. 313-322

Authors: Wilson JL, Altman RB

PMID 29199461

(Project #24)

2017 November 01

Toward Multimodal Signal Detection of Adverse Drug Reactions

Journal of Biomedical Informatics, Volume 76, pp. 41-49

Authors: Harpaz R, DuMouchel W, Schuemie M, Bodenreider O, Friedman C, Horvitz E, Ripple A, Sorbello A, White RW, Winnenburg R, Shah NH

PMID 29081385

(Project #2)

2017 September 01

Development of an Automated Assessment Tool for MedWatch Reports in the FDA Adverse Event Reporting System

Journal of the American Medical Informatics Association, Volume 25, Issue 5, pp. 913-920

Authors: Han L, Ball R, Pamer CA, Altman RB, Proestel S

PMID 28371826

(Project #1)

2017 June 15

Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1

Journal of Chemical Information and Modeling, Volume 57, Issue 6, pp. 1402-1413

Authors: Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM

PMID 28562037

(Project #3)

2017 May 05

The Effect of Uremic Solutes on the Organic Cation Transporter 2

Journal of Pharmaceutical Sciences, Volume 106, Issue 9, pp. 2551-2557

Authors: Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM

PMID 28483424

(Project #3)

2017 February 01

Mechanical Performance of Cervical Intervertebral Body Fusion Devices: A Systematic Analysis of Data Submitted to the Food and Drug Administration

Journal of Biomechanics, Volume 54, pp. 26-32

Authors: Peck JH, Sing DC, Nagaraja S, Peck DG, Lotz JC, Dmitriev AE

PMID 28256243

(Project #8)

2016 September 20

Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1

Clinical Pharmacology & Therapeutics, Volume 100, Issue 5, pp. 524-536

Authors: Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM

PMID 27447836

(Project #3)

2016 October 27

From the Patient's Point of View, How Should Minimally Invasive Glaucoma Surgeries be Evaluated?

American Journal of Ophthalmology, Volume 172, pp. xii-xiv

Authors: Qui N. Cui, Kuldev Singh, George L. Spaeth

PMID 28327295

(Project #14)

2016 September 28

A Molecular Basis for Innovation in Drug Excipients

Clinical Pharmacology & Therapeutics, Volume101, Issue 3, pp. 320-323

Authors: John J. Irwin, Joshua Pottel, Ling Zou, Hong Wen, Susan Zuk, Xinyuan Zhang, Teague Sterling, Brian K., Shoichet, Robert Lionberger, Kathleen M. Giacomini

PMID 27557422

(Project #15A, 15B)

2016 August 09

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3

Molecular Pharmaceutics, Volume 12, Issue 9, pp. 3130-40

Authors: Chia-Hsiang Hsueh, Kenta Yoshida, Ping Zhao, Timothy W Meyer, Lei Zhang, Shiew-Mei Huang, Kathleen M Giacomini

PMID 27467266

(Project #3)

2016 June 14

Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans

Frontiers in Pharmacology, Volume 7, Article 135 (pp. 1-12)

Authors: Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R

PMID 27378919

(Project #)

2016 June 14

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin

Clinical Pharmacokinetics, Volume 55, Issue 6, pp. 711-21

Authors: Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM

PMID 26597253

(Project #)

2016 April 20

A Research Roadmap for Next Generation Sequencing Informatics

Science Translational Medicine, Volume 8, Issue 335, Article 335ps10 (pp. 1-4)

Authors: Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante DC, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T

PMID 27099173

(Project #16A)

2015 November 25

Unmet Needs: Research Helps Regulators do their Jobs

Science Translational Medicine, Volume 7, Issue 315, Article 315ps22 (pp. 1-7)

Authors: Altman RB, Khuri N, Salit M, Giacomini KM

PMID 26606966

2015 November 16

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Molecular Pharmaceutics, Volume 12, Issue 12, pp. 4301-10

Authors: Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM

PMID 26528626

(Project #)

2015 July 31

A Method for Systematic Discovery of Adverse Drug Events from Clinical Notes

Journal of the American Medical Informatics Association, Volume 22, Issue 6, pp. 1196-204

Authors: Wang G, Jung K, Winnenberg R, Shah NH

PMID 26232442

(Project #2)