Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proceedings of the National Academy of Sciences, 202016093. https://doi.org/10.1073/pnas.2016093117
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nat Chem Biol. 2020 Oct 20. Epub ahead of print. PMID: 33082574. 10.1038/s41589-020-00679-1
Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding
MSphere, 5(5), 1–11.
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection
MedRxiv, 2020.08.17.20176925. Under review
Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity
BioRxiv, 2020.05.21.109157. Under review
We are keenly focused on how cells remodel their extracellular proteome in health and disease. To understand and disrupt human disease-associated signaling processes, we develop enabling technologies with protein & antibody engineering and site-directed small molecule approaches.
Recent news
| Dec 14th, 2019 |
Last Christmas Party of the decade!    |
| Nov 25th, 2019 |
Farewell to Duy Nguyen!  |
| Nov 4th, 2019 |
Great dinner at CCB retreat with Wiita lab!  |
| Sept 10, 2019 | Go Giants at our annual game outing! |
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Aug 27, 2019 |
Farewell and best wishes to Professor Amy Weeks.  |
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Jul 31, 2019 |
Welcome Julia Xu to the world!  |
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Jun 27, 2019 |
 Thanks to the Quantitative Biosciences Institute (QBI) for their initiative to get to know each private investigator. Details: Interview with Jim Wells. |
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Jun 26, 2019 |
Congrats and thanks to Ninwe Maraha for our lab being awarded the LivingGreen certification from the Office of Sustainability. Details: School of Pharmacy leads in LivingGreen certifications.  |
| Mar 17, 2019 |
Congrats to Cole Bracken for passing his qualifying exam.  |
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