Because James Wells is a common name, his publications are also manually curated in PubMed:

James Wells, PhD, on PubMed

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Mahuron, K. M., Moreau, J. M., Glasgow, J. E., Boda, D. P., Pauli, M. L., Gouirand, V., Panjabi, L., Grewal, R., Luber, J. M., Mathur, A. N., Feldman, R. M., Shifrut, E., Mehta, P., Lowe, M. M., Alvarado, M. D., Marson, A., Singer, M., Wells, J., Jupp, R., Daud, A., Rosenblum, M. D. (2020). Layilin augments integrin activation to promote antitumor immunity. Journal of Experimental Medicine, 217(9). https://doi.org/10.1084/jem.20192080

Lim, S. A. & Wells, J. A. (2020) Split enzymes: Design principles and strategy. Methods Enzymol. 1–22. https://doi.org/10.1016/bs.mie.2020.04.036

Weeks, A.M., Byrnes, J.R., Lui, I., and Wells, J.A. (2020). Mapping proteolytic neo-N termini at the surface of living cells. Deposited in bioRxiv https://doi.org/10.1101/2020.02.23.961904

Elledge, S.K., Tran, H.L., Christian, A.H., Steri, V., Hann, B., Toste, F.D., Chang, C.J., and Wells, J.A. (2020). Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proc. Natl. Acad. Sci. U. S. A. In press


Kevin K. Leung, Gary M. Wilson, Lisa L. Kirkemo, Nicholas M. Riley, Joshua J. Coon, James A. Wells (2019). Broad and thematic remodeling of the surface glycoproteome on isogenic cells transformed with driving proliferative oncogenes. doi: https://doi.org/10.1101/808139 https://www.biorxiv.org/content/10.1101/808139v1

Wei J, Leung KK, Truillet C, Ruggero D, Wells JA, and Evans MJ. (2019) Profiling the surfaceome identifies therapeutic targets for cells with hyperactive mTORC1 signaling. MCP In press

Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M (2019). Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron 103(3):412-422.e4


Maureen E. Hill, Anil Kumar, James A. Wells, Tom C. Hobman, Olivier Julien, and Jeanne A. Hardy (2018). The unique cofactor region of Zika virus NS2B-NS3 protease facilitates cleavage of key host proteins. ACS Chem. Biol. 13 (9), pp 2398–2405

Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, and Wells JA. (2018) Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome. PNAS 116(2): 695-700

Mou Y, Zhou X, Leung K, Martinko AJ, Yu J-Y, Chen W, and Wells JA. (2018) Engineering improved anti-phosphotyrosine antibodies based on immuno-convergent binding motif. J. Am. Chem. Soc. 140(48): 16615-16624

Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks III CL, Fierke CA, Mapp AK. (2018) Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. PNAS 115 (36) 8960-8965

Keedy D.A., Hill Z.B., Biel J.T., Kang E., Rettenmaier T.J., Brandao-Neto J., Pearce N.M., von Delft F., Wells J.A., Fraser J.S. (2018) "An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering." eLife 2018;7:e36307 PubMed

Pollock S.B., Hu A., Mou Y.M., Martinko A.J., Julien O., Hornsby M., Ploder L, Adams J.J., Geng H., Muschen M., Sidhu S., Moffat J, Wells J.A. (2018) Highly multiplexed and quantitative cell surface protein profiling using genetically barcoded antibodies. Proc. Natl. Acad. Sci. U.S.A. 115(11):2836-2841PubMed

Kroemer G., et al., Wells J.A., Wood W., Yuan J., Zakeri Z., Zhivotovsky B., Zitvogel L., Melino G. and Kroemer G. (2018) "Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018." Cell Death Differ. 25:486-541PubMed

Martinko A.J., Truillet C., Julien O., Diaz J.E., Horlbeck, M.A., Whiteley G., Blonder J., Weissman J.S., Bandyopadhyay S., Evans M.J., Wells J.A. (2018) "Targeting RAS Driven Human Cancer Cells with Antibodies to Upregulated and Essential Cell-Surface Proteins." eLife. 2018;7:e31098 PubMed
eLife Press Release
UCSF News Center
Biocentury News

Hill Z.B., Martinko A.J., Nguyen D.P., Wells J.A. (2018) "Human Antibody-Based Chemically Induced Dimerizers for Cell Therapeutic Applications." Nat. Chem. Biol. 14:112-117PubMed
F1000 recommendation

Weeks A.M. and Wells J.A. (2017) "Engineering peptide ligase specificity by proteomic identification of ligation sites." Nat. Chem. Biol. 14:50-57PubMed
Nat. Chem. Biol. News and Views
F1000 recommendation


Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE. (2017) "Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades." Molecular Cancer Research: MCR. 2018; 16(1):58-68.PubMed

Smart A.D., Pache R.A., Thomsen N., Kortemme T., Davis G.W., Wells J.A. (2017) "Engineering a Light-Activated Caspase-3 for Precise Ablation of Neurons in Vivo." Proc. Natl. Acad. Sci. U.S.A. 114:E8174-E8183
ACS Chem. Bio. Spotlight (PDF)

Diaz J.E., Morgan C.W., Minogue C.E., Hebert A.S., Coon J.J., Wells J.A. (2017) "A Split-Abl Kinase for Direct Activation in Cells." Cell Chem. Bio. 24:1-9 PubMed

Liu T.Y., Huang H.H., Wheeler D., Xu Y., Wells J.A., Song Y.S., Wiita A.P. (2017) "Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics." Cell Syst. 4:636-644 PubMed

Julien O. and Wells J.A. (2017) "Caspases and their substrates" Cell Death Differ. 24:1380-1389 PubMed

Lin S., Yang X., Jia S., Weeks A.M., Hornsby M., Lee P.S., Nichiporuk R.V., Iavarone A.T., Wells J.A., Toste F.D., Chang C.J. (2017) "Redox-based reagents for chemoselective methionine bioconjugation." Science 355:597-602 PubMed

Tran H.L., Lexa K.W., Julien O., Young T.S., Walsh C.T., Jacobson M.P., and Wells J.A. (2017) "SAR and molecular mechanics reveal the importance of ring entropy in the biosynthesis and activity of a natural product" J. Am. Chem. Soc. 139:2541-2544 PubMed

Calvo S.E., Julien O., Clauser K.R., Shen H., Kamer K.J., Wells J.A. Mootha V.K. (2017) "Comparative analysis of mitochondrial N-termini from mouse, human, and yeast" Mol. Cell. Proteomics. 16:512-523 PubMed


Spangler B., Fontaine S.D., Shi Y., Sambucetti L.C., Mattis A.N., Hann B., Wells J.A., and Renslo A.R. (2016) "A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron is Effective in Multiple Preclinical Cancer Models" J. Med. Chem (in press) PubMed

Ye X., Chan K.C., Waters A.M., Bess M., Harned A., Wei B.R., Loncarek J., Luke B.T., Orsburn B.C., Hollinger B.D., Stephens R.M., Bagni R., Martinko A., Wells J.A., Nissley D.V., McCormick F., Whiteley G. and Blonder J. (2016) "Comparative proteomics of a model MCF10A‐KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface" Oncotargets (in press) PubMed

Henager SH., Chu N., Chen Z., Bolduc D., Dempsey D.R., Hwang Y., Wells J.A., Cole P.A. (2016) "Enzyme-catalyzed expressed protein ligation." Nat. Methods 13:925-927 PubMed

Hill Z.B., Pollock S.B., Zhuang Z., Wells J.A. (2016) "Direct proximity tagging of small molecule protein targets using an engineered NEDD8 ligase" J. Am. Chem. Soc. 138:13123-13126

Wang W., Nguyen L.T., Burlak C., Chegini F., Guo F., Chataway T., Ju S., Fisher O., Miller D.W., Datta D., Wu F., Wu C., Landeru A., Wells J.A., Cookson M.R., Boxer M.B., Thomas C.J, Gai W.P., Ringe D., Petsko G.A., and Hoang Q.Q. (2016) "Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein." Proc. Natl. Acad. Sci. U.S.A. 113:9587-9592 PubMed

Spangler B., Morgan C.W., Vander Wal M.N., Chang C.J., Hann B., Wells J.A., and Renslo A.R. (2016) "A reactivity-based probe of the intracellular labile ferrous iron pool." Nat. Chem. Biol. 12:680-685 PubMed

Seaman J.E., Julien O., Lee P.S., Rettenmaier T.J., Thomsen N.D., Wells J.A. (2016) "Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues" Cell Death Differ. 23:1717-1726 PubMed
F1000 recommendation

Nguyen D.P., Miyaoka Y., Gilbert L.A., Mayerl S.J., Lee B.H., Weissman J.S., Conklin B.R., and Wells J.A. (2016) "Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity." Nat. Commun. 7:12009. PubMed

Hill, M.E., MacPherson D.J., Wu P. Julien O., Wells J.A., and Hardy J.A. (2016) "Reprogramming Caspase‑7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition." ACS Chem. Biol. 11:1603-1612

Julien O., Zhuang M., Wiita A.P., O’Donoghue A.J., Knudsen G.M., Craik C.S., and Wells J.A. (2016) "Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles." Proc. Natl. Acad. Sci. U.S.A. 113:E2001-2010 PubMed

Cimermancic P., Weinkam P., Rettenmaier T.J., Bichmann L., Keedy D.A., Woldeyes R.A., Schneidmann D., Demerdash O.N., Mitchell J.C., Wells J.A., Fraser J.S., Sali A. (2016) "CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites." J. Mol. Biol. 428:709-719 PubMed


Rettenmaier J.T., Fan H., Karpiak J., Doak A., Sali A., Shoichet B., and Wells J.A. (2015) "Allosteric small-molecule modulators of the protein kinase PDK1 discovered by virtual screening" J. Med. Chem. 58:8285-8291 PubMed

Hornsby M., Paduch M., Miersch S., Sääf A., Matsuguchi T., Lee B., Wypisniak K., Doak A., King D., Usatyuk S., Perry K., Lu V., Thomas W., Luke J., Goodman J., Hoey R.J., Lai D., Griffin C., Li Z., Vizeacoumar F.J., Dong D., Campbell E., Anderson S., Zhong N., Gräslund S., Koide S., Moffat J., Sidhu S., Kossiakoff A., and Wells J.A. (2015) "A High Through-put Platform for Recombinant Antibodies to Folded Proteins." Mol. Cell. Proteomics. 10:2833-2847 PubMed

Morgan C.W., Diaz J.E., Zeitlin S.G., Gray D.C., and Wells J.A. (2014) "Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling." Proc. Natl. Acad. Sci. U.S.A. 112:8344-8349 PubMed

Miersch S., Li Z., Hanna R., McLaughlin M.E., Hornsby M., Matsuguchi T., Paduch M., Sääf A., Wells J.A., Koide S., Kossiakoff A., and Sidhu S.S. (2015) "Scalable high throughput selection from phage-displayed synthetic antibody libraries." J Vis Exp. 95:51492 PubMed

Koerber J.T., Hornsby M.J., and Wells J.A. (2015) "An Improved Single-chain Fab Platform for Efficient Display and Recombinant Expression." J. Mol. Biol. 427:576-586 PubMed


Rettenmaier T.J., Sadowsky J.D., Thomsen N.D., Chen S.C., Doak A.K., Arkin M.R., and Wells J.A. (2014) "A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1." Proc. Natl. Acad. Sci. U.S.A. 111:18590-18595 PubMed

Ordureau A., Sarraf S.A., Duda D.M., Heo J.M., Jedrykowski M.P., Sviderskiy V.O., Olszewski J.L., Koerber J.T., Xie T., Beausoleil S.A., Wells J.A., Gygi S.P., Schulman B.A., Harper J.W. (2014) "Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis." Mol. Cell. 56:360-375 PubMed

Julien O., Kampmann M., Bassik M.C., Zorn J.A., Venditto V.J., Shimbo K., Agard N.J., Shimada K., Rheingold A.L., Stockwell B.R., Weissman J.S., and Wells J.A. (2014) "Unraveling the mechanism of cell death induced by chemical fibrils." Nat. Chem. Biol. 10:969-976 PubMed

Arkin M.R., Tang Y., Wells J.A. (2014) "Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality." Chem. Biol. 21:1102-1114. PubMed

Wiita A.P., Seaman J.E., Wells J.A. (2014) "Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini." Methods Enzymol. 2014;544:327-358 PubMed

Morgan C.W., Julien O., Unger E.K., Shah N.M., Wells J.A. (2014) "Turning on caspases with genetics and small molecules." Methods Enzymol. 2014;544:179-213 PubMed

Wells J.A. and Kossiakoff A.A. (2014) "Cell biology. New tricks for an old dimer." Science. 2014 344:703-704 PubMed

Wiita A.P., Hsu G.W., Lu C.M., Esensten J.H., Wells J.A. (2014) "Circulating Proteolytic Signatures of Chemotherapy-induced Cell Death in Humans Discovered by N-terminal Labeling." Proc. Natl. Acad. Sci. 111:7594-7599 PubMed

Lodge J.M, Rettenmaier J.T., Wells J.A., Pomerantz W.C., and Mapp A.K. (2014) "FP tethering: a screening technique to rapidly identify compounds that disrupt protein–protein interactions"
Med. Chem. Commun. 5:370-375 PubMed


Ostrem J.M., Peters U., Sos M.L., Wells J.A., Shokat K.M. (2013) "K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions." Nature. 503:548-551 PubMed

Wiita A.P., Ziv E., Wiita P.J., Urisman A., Julien O., Burlingame A.L., Weissman J.S., and Wells J.A. (2013) "Global cellular response to chemotherapy-induced apoptosis." eLife. 2:e01236 PubMed

Koerber J.T, Thomsen N.D., Hannigan B.T., Degrado W.F., Wells J.A. (2013) "Nature-inspired design of motif-specific antibody scaffolds." Nat. Biotechnol. 31:916-921 PubMed

Carter P.J., Hazuda D., Wells J.A. (2013) "Next generation therapeutics." Curr Opin Chem Biol. 17. 317-319 PubMed

Yang C.F., Chiang M.C., Gray D.C., Prabhakaran M., Alvarado M., Juntti S.A., Unger E.K., Wells J.A., Shah N.M. (2013) "Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males." Cell. 153:896-909 PubMed

Thomsen N.D., Koerber J.T., Wells J.A. (2013) "Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation." Proc. Natl. Acad. Sci. 110. 8477-8482 PubMed

Datta D., McClendon C.L., Jacobson M.P., Wells J.A. (2013) "Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3." J. Biol. Chem. 288. 9971-9981 PubMed

Wang N., Majmudar C.Y., Pomerantz W.C., Gagnon J.K., Sadowsky J.D., Meagher J.L., Johnson T.K., Stuckey J.A., Brooks C.L. 3rd, Wells J.A., Mapp A.K. (2013) "Ordering a Dynamic Protein Via a Small-Molecule Stabilizer." J. Am. Chem. Soc. 135, 3363-2266 PubMed

Crawford E.D., Seaman J.E., Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H., Zhuang M., Chalkley R.J., Wells J.A. (2013) "The DegraBase: a database of proteolysis in healthy and apoptotic human cells." Mol. Cell. Proteomics 12, 813-824 PubMed

Zhuang M., Guan S., Wang H., Burlingame A.L., Wells J.A. (2013) "Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator" Mol. Cell. 49, 273-282.


Crawford E.D., Seaman J.E., Barber A.E., David D.C., Babbitt P.C., Burlingame A.L., Wells J.A. (2012) "Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis" Cell Death Differ. 19, 2040-2048. PubMed

Zorn J.A., Wolan D.W., Agard N.J., Wells J.A. (2012) "Fibrils Colocalize Caspase-3 with Procaspase-3 to Foster Maturation" J. Biol. Chem. 287, 33781-22795. PubMed

Shimbo K., Hsu G.W., Nguyen H., Mahrus S., Trinidad J.C., Burlingame A.L., and Wells J.A. (2012) "Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis" Proc Natl Acad Sci U S A. 109, 12432-12437. PubMed

Agard N.J., Mahrus S., Trinidad J.C., Lynn A., Burlingame A.L., Wells J.A. (2012) "Global kinetic analysis of proteolysis via quantitative targeted proteomics" Proc Natl Acad Sci U S A. 109, 1913-1918. PubMed


Zorn J.A., Wille H., Wolan D.W., Wells J.A. (2011) "Self-Assembling Small Molecules Form Nanofibrils That Bind Procaspase-3 to Promote Activation" J Am Chem Soc. 133, 19630-19633. PubMed

Gao J. & Wells J.A. (2011) "Identification of Specific Tethered Inhibitors for Caspase-5" Chem Biol Drug Des. 79, 209-215. PubMed

Tang Y., Wells J.A. & Arkin M.R. (2011) "Structural and enzymatic insights into caspase-2 substrate recognition and catalysis" J Biol Chem. 286, 34147-34154. PubMed

Crawford E.D. & Wells J.A. (2011) "Caspase substrates and cellular remodeling" Annu Rev Biochem. 80, 1055-87. PubMed

Sadowsky, J., Burlingame, M., Wolan, D., McClendon, C., Jacobson, M., & Wells, J.A. (2011) "Turning a protein kinase (PDK1) on or off from a single allosteric site via disulfide trapping" Proc. Natl. Acad. Sci. USA. 108, 6056-6061. PubMed

Perez-Paya, E., Orzaez, M, Mondragon, L, Wolan, D, Wells, JA, Messeguer, A, Vincent, MJ. (2011) "Molecules that modulate Apaf-1 activity" Med Res Rev. 31, 649-675. PubMed


Gray, D.C., Mahrus, S. & Wells. J.A. (2010) "Activation of specific apoptotic caspases with an engineered small molecule activated protease" Cell 142, 637-646. PubMed

Barkan, D.T., Hostetter, D.R., Mahrus, S., Pieper, U., Wells, J.A., Craik, C.S. & Sali, A. (2010) "Prediction of protease substrates using sequence and structure features" Bioinformatics 26, 1714-22. PubMed

Agard, N.J, Maltby, D. & Wells, J.A. (2010) "Inflammatory stimuli regulate caspase substrate profiles" Mol. Cell. Proteomics 5, 880-893. PubMed

Zorn, JA, & Wells, JA. (2010) "Turning enzymes ON with small molecules" Nat Chem Biol 3, 179-188. PubMed

Wildes, D & Wells, J.A. (2010) "Sampling the N-terminal proteome of human blood" Proc. Natl. Acad. Sci. USA 107, 4561-4566. PubMed


Wolan DW, Zorn JA, Gray DC, Wells JA. (2009) "Small-molecule activators of a proenzyme" Science 326, 853-858. PubMed

Agard, N. & Wells, J.A. (2009) "Methods for the proteomic identification of protease substrates" Curr Opin Chem Biol 13, 503-509. PubMed

Hardy, J. & Wells, J.A. (2009) "Dissecting an allosteric switch in caspase-7 using chemical and mutational probes" Journal of Biological Chemistry 284(38), 26063-26069. Journal of Biological Chemistry 284(38), 26063-26069. PubMed

Gao J, Sidhu SS, Wells JA. (2009) "Two-state selection of conformation-specific antibodies" Proc. Natl. Acad. Sci USA 106, 3071-3076. PubMed


Yoshihara HA, Mahrus S, Wells JA. (2008) Bioorg Med Chem Lett. 18, 6000-6003. "Tags for labeling protein N-termini with subtiligase for proteomics"


Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA. (2008) "Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini" Cell 134, 866-876. PubMed

Datta D, Scheer JM, Romanowski MJ, Wells JA. (2008) J Mol Biol. 381, 1157-1167. "An allosteric circuit in caspase-1" PubMed


Wells JA, McClendon CL. (2007) Nature 450, 1001-1009. "Reaching for high-hanging fruit in drug discovery at protein-protein interfaces" PubMed


Thanos, C.D., DeLano, W.L. and Wells, J.A. (2006) "Hot-spot mimicry of a cytokine receptor by a small molecule" PubMed

Scheer, J., Romanowski, M. and Wells, J.A. (2006) Proc. Natl. Acad. Sci. USA 103, 7595-7600. "A Common Allosteric Site and Mechanism in Caspases" PubMed


Scheer, J., Wells, J.A. and Romanowski, M. (2005) Protein Expr. Purif. 148-153. "Malonate-assisted purification of human caspases" PubMed

Buck, E. and Wells, J.A. (2005) Proc. Natl. Acad. Sci. USA 102, 2719-2724. "Disulfide Trapping to Localize Small Molecule Agonists and Antagonists for the Complement 5a Receptor" PubMed

Buck, E., Bourne, H. and Wells, J.A. (2005) J. Biol. Chem 280, 4009-4012. "Site-specific Disulfide Capture of Agonist and Antagonist Peptides to the C5a Receptor" PubMed


Hardy, J.A. and Wells, J.A. (2004) Curr Opin Struct Biol., 706-715. "Searching for new allosteric sites in enzymes." PubMed

Hardy, J.A., Lam, J., Nguyen, J.T., O’Brien, T and Wells, J.A. (2004) "Discovery of an Allosteric Site in Caspases." Proc. Natl. Acad. Sci. USA 101, 12461-12466. PubMed

Erlanson, D.A., Wells, J.A. and Braisted, A.B. (2004) "TETHERING: Fragment-based Drug Discovery." Annu. Rev. Biophys. Biomol Struct. 33, 199-233. PubMed

Stroud, R.M. and Wells, J.A. (2004) Science STKE, 2004, re7. "Mechanistic Diversity of Cytokine Signaling Across Cell Membranes" PubMed

Arkin, M.R. and Wells, J.A. (2004) Nature Rev. Drug Disc. 3, 301-317. "Small Molecule Inhibitors of Protein-Protein Interactions: Progressing Towards the Dream" PubMed


Thanos, C.D., Randal, M., and Wells, J.A. (2003) J. Am. Chem. Soc., 125, 15280-15281. "Potent Small-molecule Binding to a Dynamic Hot-spot on IL-2" PubMed

Nguyen, J. and Wells, J.A. (2003) Machinery as a Mechanism to target Cancer Cells" Proc. Natl. Acad. Sci USA, 100, 7533-7538. "Direct Activation of the Apoptosis PubMed

Arkin, M.R., Randal, M., DeLano, W., Hyde, J., Loung, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C. (2003) "Binding of Small Molecules to an Adaptive Protein:Protein Interface" Proc. Natl. Acad. Sci USA 100, 1603-1608. PubMed

Selected Earlier Publications

Erlanson, D.A., Braisted, A.C., Raphael, D.R., Randal, M., Stroud, R.M., Gordon, E.M. and Wells, J.A. (2000) Proc. Natl. Acad. Sci. USA 97, 9367-9372. "Site-Directed Ligand Discovery"

DeLano, W.L., Ultsch, M.H., De Vos, A.M. and Wells, J.A. (2000) Science 287, 1279-1283. "Convergent Solutions to Binding at a Protein-Protein Interface"

Atwell, S. and Wells, J.A. (1999) Proc. Natl. Acad. Sci USA 96, 9497-9502. "Selection for Improved Subtiligases by Phage Display"

Ballinger, M.D. and Wells, J.A. (1998) Nature Struct. Biol. 5, 938-940. "Will Any Dimer Do?" News and Views

Clackson, T., Ultsch, M., Wells, J.A. and De Vos, A.A. (1998) J. Mol. Biol. 277, 1111-1128. "Structural and Functional Analysis of the 1:1 Growth Hormone:Receptor Complex Reveals the Molecular Basis for Receptor Affinity"

Wiesmann, C., Fuh, G., Christinger, H.W., Eigenbrot, C., Wells, J.A., De Vos, A.M. (1997) Cell 91, 695-704. "Crystal Structure at 1.7Å resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor"

Atwell, S., Ultsch, M., De Vos, A.M. and Wells, J.A. (1997) Science 278, 1124-1127 "Structural Plasticity in a Remodeled Protein-Protein Interface"

Ellman, J., Stoddard, B., and Wells, J.A. (1997) Proc. Natl. Acad. Sci. USA 94, 2779-2782. "Combinatorial Thinking in Chemistry and Biology"

Wells, J.A. (1996) Science 273, 449-450. "Hormone Mimicry." Review.

Li, B., Tom, J.Y.K., Oare, D., Yen, R., Fairbrother, W., Wells, J.A., and Cunningham, B.C. (1995) Science 270, 1657-1660. "Minimization of a Polypeptide Hormone"

Wells, J.A. (1995) Biotechnology 13, 647-651. "Structural and Functional Epitopes in the Growth Hormone Receptor Complex"

Clackson, T. and Wells, J.A. (1995) Science 267, 383-386. " A Hot Spot of Binding Energy in a Hormone-Receptor Interface"

Chang, T.K., Jackson, D.Y., Burnier, J.P. and Wells, J.A. (1994) Proc. Natl. Acad. Sci. USA 91, 12544-12548. "Subtiligase: a Tool for Semi-synthesis of Proteins"

Jackson, D.Y., Burnier, J., Quan, C., Stanley, M., Tom, J. and Wells, J.A. (1994) Science 266, 243-247. "A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues."

Matthews, D.J. and Wells, J.A. (1993) Science 260, 1113-1117. "Substrate Phage: Selection of Protease Substrates by Monovalent Phage Display."

Fuh, G. Cunningham, B.C., Fukunaga, R., Nagata, S., Goeddel, D.V., and Wells, J.A. (1992) Science, 256, 1677-1680. "Rational Design of Potent Antagonists to the Human Growth Hormone Receptor."

Cunningham, B.C., Ultsch, M., DeVos, A.M., Mulkerrin, M.G., Clauser, K.R., Wells, J.A. (1991) Science 254, 821-825. "Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule."

Lowman, H.B., Bass, S., Simpson, N., Wells, J.A. (1991) Biochemistry 30, 10832-10838 "Engineering a Hormone for Improved Receptor binding Affinity by Monovalent Phage Display."

Cunningham, B.C., Mulkerrin, M.G., and Wells, J.A. (1991) Science 253, 545-548, "Dimerization of Human Growth Hormone by Zinc."

Cunningham, B.C., and Wells, J.A. (1991) Proc. Natl. Acad. Sci. USA 88, 3407-3411. "Rational design of receptor specific variants of human growth hormone."

Cunningham, B.C., Bass, S., Fuh, G., and Wells, J.A. (1990) Science 250, 1709-1712 "Zinc mediation of the binding of human growth hormone to the human prolactin receptor."

Cunningham, B.C., Henner, D.J. and Wells, J.A. (1990) Science 247, 1461-1465. "Engineering human prolactin to bind to the human growth hormone receptor."

Cunningham, B.C. and Wells, J.A., (1989) Science 244, 1081-1085. "High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis."

Cunningham, B.C., Jhurani, P., Ng, P. and Wells, J.A., (1989) Science 243, 1330-1336. "Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis."

Mitchinson, C. and Wells, J.A. (1989) Biochemistry 28, 4807-4815. "Protein engineering of disulfide bonds in subtilisin."

Wells, J.A. and Estell, D.A. (1988) Trends in Biochem. Sci. 13, 291-297. "Subtilisin - an enzyme designed to be engineered."

Carter, P. and Wells, J.A. (1988) Nature 332, 564-568. "Dissecting the catalytic triad of a serine protease."

Carter, P., and Wells, J.A. (1987) Science 24, 394-399. "Engineering substrate specificity by substrate-assisted catalysis."

Wells, J.A., Cunningham, B.C., Graycar, T.P., and Estell, D.A. (1987). Proc. Natl. Acad. Sci. USA 84, 5167-5171. "Recruitment of substrate specificity properties from one enzyme into a related one by protein engineering."

Wells, J.A., Powers, D.B., Bott, R.R., Graycar, T.P., and Estell, D.A. (1987) Proc. Natl. Acad. Sci. USA 84, 1219-1223. "Designing substrate specificity by protein engineering of electrostatic interactions."

Estell, D.A., Graycar, T.P., Miller, J.V., Powers, D.B., Burnier, J.P., Ng, P.G., and Wells, J.A. (1986) Science 233, 659-663. "Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering."

Wells, J.A., Powers, D.B., Bott, R.R., Katz, B.A., Ultsch, M.H., Kossiakoff, A.A., Power, S.D., Adams, R.M., Heyneker, H.H., Cunningham, B.C., Miller, J.V., Graycar, T.P., and Estell, D.A. (1987) in Protein Engineering (A.R. Liss) in press, "Protein engineering of subtilisin."

Wells, J.A. and Powers, D.B. (1986) J. Biol. Chem. 261, 6564-6570. "In vivo formation and stability of engineered disulfide bonds in subtilisin."

Wells, J.A. and Yount, R.G. (1979) Proc. Natl. Acad. Sci. USA 76, 4966-4970. "Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin sub-fragment 1."