Transporters in Drug Development: Half-Day Course
255 South Airport Boulevard, South San Francisco, CA 94080
Membrane transporters are critical determinants of drug disposition, response, and toxicity, and increasingly are being targeted in drug discovery. This half-day workshop will, through lectures and interactive cases focus on transporters in the Solute Carrier and ATP Binding Cassette Superfamilies (Nature Reviews Drug Discovery 9, 215-236, 2010), including fundamentals of transport mechanisms and kinetics, in vitro methodology for studying those mechanisms, FDA guidances for studies of transporter-mediated DDIs, and transporter polymorphisms. The emphasis will be on emerging transporters, the new guidances from the FDA on drug-drug interactions, and case based problems (Instructors: Kathy Giacomini (UCSF), Deanna Kroetz (UCSF) and Joe Polli (GSK)