Transporters in Drug Development: Half-Day Course | UCSF-Stanford Center of Excellence in Regulatory Science and Innovation (CERSI)

Details

Type Event
Date February 16, 2018
Time 12:30 PM - 5:00 PM
Location
255 South Airport Boulevard, South San Francisco, CA 94080 255 South Airport Boulevard, South San Francisco, CA 94080
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About

Membrane transporters are critical determinants of drug disposition, response, and toxicity, and increasingly are being targeted in drug discovery. This half-day workshop will, through lectures and interactive cases focus on transporters in the Solute Carrier and ATP Binding Cassette Superfamilies (Nature Reviews Drug Discovery 9, 215-236, 2010), including fundamentals of transport mechanisms and kinetics, in vitro methodology for studying those mechanisms, FDA guidances for studies of transporter-mediated DDIs, and transporter polymorphisms. The emphasis will be on emerging transporters, the new guidances from the FDA on drug-drug interactions, and case based problems (Instructors: Kathy Giacomini (UCSF), Deanna Kroetz (UCSF) and Joe Polli (GSK)