Oral Drug Delivery
Oral delivery is the preferred route for drug administration because it is less invasive than other traditional routes. The pharmaceutical and biotechnology industries are continuously developing peptides, proteins, biopolymer, and macromolecular drugs for the treatment of a variety of diseases. However, many of these new drugs are poorly bioavailable when administered orally and often fail to be therapeutically effective. We have developed hierarchical nanoengineered microparticles, microdevices, and monodispersed polymeric particles to address these challenges. We are also interested in understanding how structural cues can influence bioadhesion and drug permeability at the epithelial interface.