Oral Drug Delivery

Oral delivery is the preferred route for drug administration because it is less invasive than other traditional routes. The pharmaceutical and biotechnology industries are continuously developing peptides, proteins, biopolymer, and macromolecular drugs for the treatment of a variety of diseases. However, many of these new drugs are poorly bioavailable when administered orally and often fail to be therapeutically effective. We have developed hierarchical nanoengineered microparticles, microdevices, and monodispersed polymeric particles to address these challenges. We are also interested in understanding how structural cues can influence bioadhesion and drug permeability at the epithelial interface.

targeted attachment, enterocyte, microvilli, drug transport

Planar microdevices (left) can be used to release multiple drugs across the intestinal barrier.

unidirectional diffusion microdevices

Unidirectional diffusion microdevices a) loaded with three different fluorescent model drugs and b) coated with a fluorescent surface coating.


The cumulative release behavior of three model drugs from one planar microdevice with three different hydrogel cross-linking concentrations.