UCSF

Bone drug delivery

Osteomyelitis is a bone or bone marrow infection that requires prolonged antibiotic therapy and surgical debridement. We are developing nanoparticles that both release a therapeutic payload and restructure damaged bone.

Osteomyelitis

Acute osteomyelitis causes destruction of bone as seen in the jaw bone in the lower right of the image.

Osteomyelitis

Osteoblasts attach themselves to a calcium phosphate microparticle capable of delivering an antibiotic payload to areas of bone infection.