Bone Drug Delivery
Injectable PEGDMA Microrods for Orthopedic Regeneration
Currently, fracture repairs are approached primarily through surgical fixation or bone graft implantation, with no well- adopted biologics or injectable materials widely available to promote fracture repair. Therefore, the development of translational and cost-effective strategies to accelerate fracture repair is a high priority. We have been testing novel biologics and engineering optimal delivery systems for local and sustained administration of growth factors. To that end, we’ve fabricated hydrogel-based microparticles for the controlled release of factors with the aim of promoting repair and regeneration.
Recent Publications: Rivera KO et al. (2020). Scientific Reports.
- Topographical influence on orthopedic tissue repair
- Polycaprolactone NW delivery of β-NGF
Point(s) of contact: Kevin Rivera
Nanoparticles for drug delivery and bone formation
Osteomyelitis is a bone or bone marrow infection that requires prolonged antibiotic therapy and surgical debridement. We are developing nanoparticles that both release a therapeutic payload and restructure damaged bone.