UCSF

Transmucosal Drug Delivery

Mucous membranes lining the intestine are one physiological barrier to drug permeability. Our nanowire-coated materials dramatically increase particle adhesion and retention time of drug-delivery devices for more effective delivery through mucous membranes.

bioadhesive nanowires diagram

Mucous membranes lining the intestine are one physiological barrier to drug permeability. Our nanowire-coated materials dramatically increase particle adhesion and retention time of drug-delivery devices for more effective delivery through mucous membranes.

bioadhesive nanowires

Spherical and planar microdevices coated with nanowires can adhere to the microvilli of the intestinal mucous membranes. Contact between microparticles and intestinal cells can increase the permeability between cells and allow for increased drug delivery.