UCSF

People

Principal investigator

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Name

 

Lei Wang
Professor
[email protected]
Lei Wang’s CV

 

 

  Lei Wang received BS and MS from Peking University mentored by Zhongfan Liu, and PhD from UC Berkeley mentored by Peter G. Schultz. His graduate research resulted in the first expansion of the genetic code to include unnatural amino acids (Uaas) in 2001, for which he was awarded the Young Scientist Award by the journal Science. After postdoctoral training with Roger Y. Tsien, Wang started his group at the Salk Institute in 2005, and moved to UCSF in 2014. Wang’s group has developed new methods for the expansion of the genetic code in a variety of cells and model organisms, including mammalian cells, stem cells, C. elegans, and embryonic mouse. His group discovered that release factor one (RF1) is nonessential in E. coli, and engineered autonomous bacteria capable of incorporating Uaas at multiple sites with high efficiency. By developing the concept of proximity-enabled bioreactivity, Wang’s group designed and demonstrated that a new class of Uaas, the latent bioreactive Uaas, can be genetically encoded in live systems. These latent bioreactive Uaas enable novel covalent bonding abilities to be specifically introduced into proteins and biosystems, opening new avenues for in vivo protein engineering, biological research, and biotherapeutics. Wang is a recipient of 2003 Merck Fellow of Damon Runyon Cancer Research Foundation, 2003 Young Scientist Award by Science, 2004 TR35 Top Young Innovator by MIT Technology Review, 2006 Beckman Young Investigator, 2006 Searle Scholar, 2008 Basil O'Connor Starter Scholar by March of Dimes, 2008 NIH Director’s New Innovator Award, and the 2021 Emil Thomas Kaiser Award by the Protein Society.

Postdoctoral fellows

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Name, email

Degree

Li Cao
[email protected]

PhD, Nankai University

Shanshan Li
[email protected]

PhD, Georgia State University

Wei Sun
[email protected]

PhD, Max Delbrück Center for Molecular Medicine

Bingchen Yu 
[email protected]

PhD, Georgia State University

Graduate students

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Name, graduate program, email

Degree

Viktoriya Berdan
Chemistry and Chemical Biology (CCB)
[email protected]

BS, New York University

Paul Klauser
Chemistry and Chemical Biology (CCB)
[email protected]

BS, University of Illinois at Urbana-Champaign