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Research interests

Principal investigator

Savic

Rada Savic, PhD

Principal Investigator

[email protected]

I work on methodological advancement and application of systems pharmacology models to drug development and therapy optimization problems in tuberculosis (TB), HIV, oncology, and diabetes.

Lab members

Strydom

Natasha Strydom, PhD

Postdoctoral Scholar

[email protected]

I am involved in modeling preclinical data with a current focus on emergence of antimycobacterial resistance. My work aims to integrate with translational models to predict improved treatment outcomes in patients with tuberculosis.

Ali Mohamed Ali, PhD

Postdoctoral Scholar

[email protected]

I am working on development of clinical mechanistic PKPD-resistance models for malaria prevention and treatment. I want to use physiological based pharmacokinetic model to aid dose optimization in children.

Chores Wang, PhD

Postdoctoral Scholar

[email protected]

My research interests lie in the application of computational strategies to refine the relationship between mouse and human PK/PD. Currently, I am working on a translational mouse-to-human PK/PD model of tuberculosis treatment for regimen optimization and better outcomes prediction in Phase 2 clinical studies and beyond. My ultimate goal is to use translational modeling to help bridge preclinical-clinical divide.

Belén Pérez Solans, PhD

Postdoctoral Scholar

[email protected]

I work on computational methods to study the interplay between longitudinal dynamics of drug and biomarkers, and disease, with a focus on paediatric population PK and PD, and model-informed precision dosing for tuberculosis (TB) and oncology.

Agathe Béranger, MD, PhD

Postdoctoral Scholar

[email protected]

I work in PICU and I have a real interest in PK. The two disciplines together allow us to understand the physiopathological changes occurring in critically ill children and their impact on the pharmacokinetics of anti-infectious drugs. The goal is to achieve optimal prescription in this vulnerable population.

Ségolène Siméon, PharmD, PhD

Postdoctoral Scholar

[email protected]

In order to determine the impact of human phenotype on recommended malaria treatments, I use computational models to optimize dosing regimens according to the patients and their physiological characteristics.

Jordan Brooks, PharmD

Clinical Pharmacology Fellow, Joint mentorship with Dr. Janel Long-Boyle

[email protected]

My interest is in PK/PD modeling of narrow therapeutic window medications utilized in pediatric bone marrow transplant and translating such models into clinically useful tools to enable model-informed dosing and help improve patient outcomes.

Ryo Miyakawa, MD, MPH

Clinical Pharmacology Fellow

[email protected]

I am a pediatric pulmonologist, who is currently an infectious disease fellow. I am interested in how pharmacokinetics are affected by the gut microbiome and nutritional status in the treatment of chronic respiratory tract infections, such as tuberculosis.

Erika Wallender, MD

Assistant Professor, Department of clinical Pharmacy

[email protected]

I am interested in improving how antimalarials are used for malaria treatment and prevention in pregnant women and children by using PK/PD modeling to relate antimalarial drug exposure to toxicity, clinical and preventive efficacy, and drug resistance. Our clinical work is conducted in a collaboration between UCSF and the Infectious Diseases Research Collaboration in Kampala, Uganda.

Janice Goh

Joint Graduate Student with the Turnbaugh Lab

[email protected]

I am interested in the involvement of the microbiome in host gene expression and how these gene changes can affect host metabolism and clearance. I utilize a variety of experimental methods including microbiology, gnotobiotics and next generation sequencing as well as computational methods like PK modeling to answer this question.

Imperial

Marjorie Imperial, PhD

Postdoctoral Scholar

[email protected]

I am developing computational models that investigate the variability observed in drug response. Ultimately, the goal is to apply these models to provide personalized medicine for improved diagnosis, therapies, and prognosis of diseases.

Emma Hughes

Graduate Student

[email protected]

I am developing computational models to investigate the effects of patient and disease characteristics on malaria prevention and treatment strategies. Our target populations are young children and pregnant women given their vulnerability to malaria. Ultimately, our goal is to provide optimized dosing recommendations to inform clinical practice and policies.

Jackie Ernest

Graduate Student

[email protected]

I am developing translational tools to better predict clinical outcomes using preclinical data. Currently, I am using a rabbit model of tuberculosis to rank drugs and optimize dose for lesion-centric efficacy and sterilization.

Vincent Chang

Graduate Student

[email protected]

I am using computational methods to investigate novel tuberculosis biomarkers or combinations of biomarkers that can adequately monitor disease progression, follow early treatment response, and predict long term clinical outcomes.

Craig Shaffer

Research Data Analyst

[email protected]

I am a dedicated and experienced problem-solver passionate about providing global-health and infectious-disease insight, innovation, and impact through data-driven modeling and decision analytics.

Staff

Reanna Suela

Administrative Analyst

[email protected] 

 

Former lab members

Who

Formerly

Now

Kendra Radtke, PharmD Graduate Student

Clinical Pharmacology and Therapeutics Fellow in the Butte Lab at UC San Francisco

LinkedIn

Hwi-yeol (Thomas) Yun, PhD

Visiting Scholar

Associate Professor, College of Pharmacy, Chungnam National University

ORCID

Huy Ngo, PharmD, PhD Postdoctoral Scholar

Genentech-CERSI Clinical Pharmacology Fellow

LinkedIn

Maria Garcia-Cremades Mira, PhD Postdoctoral Scholar

Assistant Professor in the School of Pharmacy in la Universidad Complutense de Madrid

LinkedIn

Isaac Cohen, PharmD T32 Clinical Pharmacology Fellow Clinical Pharmacologist at Denali Therapeutics
Leah Gonzalez Jarlsberg Research Data Analyst Research Analyst at UCSF Pulmonary & Critical Care Division
Veronika Westergren Visiting Scholar Graduate student at Uppsala University
Nan Zhang, PhD Academic Coordinator Senior Clinical Pharmacokineticist at AstraZeneca
Priya Jayachandran, PharmD, MS Clinical Pharmacology Fellow Pharmacometrician at Pfizer
Peter Lu Administrative Analyst Research Data Analyst at UCSF
Amelia Deitchman, PharmD, PhD Clinical Pharmacology Fellow T32 Clinical Pharmacology Fellow at UCSF
Daniel Chan, PhD Postdoctoral Scholar Scientist at BioMarin Pharmaceutical Inc
William Fox, MS Research Data Analyst Computer Vision Engineer at Presto
Sarah Shaffer, MA Writer Web & Content Editor at The Wonder Kid
Katarina Vucicevic, PhD Visiting Scholar Assistant Professor at University of Belgrade
Michael Martin, PhD Postdoctoral Scholar Associate at Prescient Healthcare Group

Ron Keizer, PhD

Postdoctoral Scholar and Research Scientist

CSO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing

Sirj Goswami, PhD

PhD student in Pharmaceutical Sciences and Pharmacogenomics

CEO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing

Jennifer Hibma, PharmD

Postdoctoral Scholar

Quantitative clinical pharmacologist at Pfizer

Yookhwan Noh, PhD

Postdoctoral Scholar

Assistant professor at Ulsan University Hospital

Sneha Gupta, PhD

Clinical Pharmacology Fellow

Clinical pharmacologist at Gilead Sciences, Inc.

Jodi Parikh, PhD

Visiting Scholar

Postdoc at Rutgers New Jersey Medical School

Allison Komirenko

Visiting Scholar

Biotech Clinical Research Fellow at Achaogen

Viktoria Grahnen, MSc Junior Specialist Labeling Strategist Manager at AbbVie
Malte Larsen, MSc Junior Specialist PhD Student at University of Copenhagen
John Fors, MS, NP-C Specialist Nurse Practitioner at Stanford Health Care
Desiree Legetth, MSc Junior Specialist Quality Assurance Officer at AstraZeneca
Niels Erik Olesen, PhD Junior Specialist Postdoc at Center for Research, University of Copenhagen
Ana Kalezic, MSc Junior Specialist PhD student at Uppsala University
Benjamin Guiastrennec, PharmD, MS Visiting Graduate Student

PhD Student at Uppsala University

Yusi Chen Visiting Graduate Student Graduate Student at Tsinghua University

Imke Bartelink, PhD

Clinical Pharmacology Fellow

Senior Pharmacometrician at MedImmune
Daniel Chan, PhD Postdoctoral Scholar Scientist at BioMarin Pharmaceutical Inc
Andrew Gewitz, PhD Postdoctoral Scholar

Clinical Pharmacologist at Regeneron

Stella Belonwu, BS Graduate Student Graduate Student at UCSF