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Research interests

Principal investigator

Savic

Rada Savic, PhD

Principal Investigator

[email protected]

I work on methodological advancement and application of systems pharmacology models to drug development and therapy optimization problems in tuberculosis (TB), HIV, oncology, and diabetes.

Lab members

Belén Pérez Solans, PhD

Postdoctoral Scholar

[email protected]

I work on computational methods to study the interplay between longitudinal dynamics of drug and biomarkers, and disease, with a focus on paediatric population PK and PD, and model-informed precision dosing for tuberculosis (TB) and oncology.

Agathe Béranger, MD, PhD

Postdoctoral Scholar

[email protected]

I work in PICU and I have a real interest in PK. The two disciplines together allow us to understand the physiopathological changes occurring in critically ill children and their impact on the pharmacokinetics of anti-infectious drugs. The goal is to achieve optimal prescription in this vulnerable population.

Ségolène Siméon, PharmD, PhD

Genentech Fellow

[email protected]

In order to determine the impact of human phenotype on recommended malaria treatments, I use computational models to optimize dosing regimens according to the patients and their physiological characteristics.

Mikhail (Michael) Zastrozhin, MD, PhD, MPH

Postdoctoral Scholar

[email protected]

My research interest is focused on solving the problem of developing precision therapy approaches to improve efficacy and safety, taking into account both clinical, anamnestic data and pharmacogenetic data. I am currently working on projects in the lab to develop tools to use preclinical data to optimize therapy, which can help improve efficacy and safety.

Pieter Van Brantegem, PharmD, PhD

Postdoctoral Scholar

[email protected]

My research interests include PK and PD modeling of therapies to treat infectious diseases. Currently, I focus on improving combination drug regimens for tuberculosis with the aim to better understand optimal dosing strategies that provide high cure rates.

Rob Christiaan van Wijk, PhD

Postdoctoral Scholar

[email protected]

I am passionate about translational pharmacology and how it enables us to predict unknown scenarios in preclinical and clinical contexts based on our understanding of the underlying quantitative relationship that drive therapeutic efficacy. It is a collaborative effort where all different expertises in experimental, clinical, and computational domains come together to answer the relevant questions in drug development and health care.
Imperial

Marjorie Imperial, PhD

Postdoctoral Scholar

[email protected]

I am developing computational models that investigate the variability observed in drug response. Ultimately, the goal is to apply these models to provide personalized medicine for improved diagnosis, therapies, and prognosis of diseases.

Ryo Miyakawa, MD, MPH

Clinical Pharmacology Fellow

[email protected]

I am a pediatric pulmonologist, who is currently an infectious disease fellow. I am interested in how pharmacokinetics are affected by the gut microbiome and nutritional status in the treatment of chronic respiratory tract infections, such as tuberculosis.

Jordan Brooks, PharmD

Clinical Pharmacology Fellow, Joint mentorship with Dr. Janel Long-Boyle

[email protected]

My interest is in PK/PD modeling of narrow therapeutic window medications utilized in pediatric bone marrow transplant and translating such models into clinically useful tools to enable model-informed dosing and help improve patient outcomes.

Erika Wallender, MD, MPH

[email protected]

I am interested in improving how antimalarials are used for malaria treatment and prevention in pregnant women and children by using PK/PD modeling to relate antimalarial drug exposure to toxicity, clinical and preventive efficacy, and drug resistance. Our clinical work is conducted in a collaboration between UCSF and the Infectious Diseases Research Collaboration in Kampala, Uganda.

Janice Goh

Graduate Student

[email protected]

I am interested in the involvement of the microbiome in host gene expression and how these gene changes can affect host metabolism and clearance. I utilize a variety of experimental methods including microbiology, gnotobiotics and next generation sequencing as well as computational methods like PK modeling to answer this question.

Emma Hughes

Graduate Student

[email protected]

I am developing computational models to investigate the effects of patient and disease characteristics on malaria prevention and treatment strategies. Our target populations are young children and pregnant women given their vulnerability to malaria. Ultimately, our goal is to provide optimized dosing recommendations to inform clinical practice and policies.

Jackie Ernest

Graduate Student

[email protected]

I am developing translational tools to better predict clinical outcomes using preclinical data. Currently, I am using a rabbit model of tuberculosis to rank drugs and optimize dose for lesion-centric efficacy and sterilization.

Vincent Chang

Graduate Student

[email protected]

I am using computational methods to investigate novel tuberculosis biomarkers or combinations of biomarkers that can adequately monitor disease progression, follow early treatment response, and predict long term clinical outcomes.

Anu Patel, PharmD

Graduate Student

[email protected]

 

I am interested in informing and advancing the development of safe and effective therapies for patients with tuberculosis globally, through PK/PD modeling and clinical trial design of novel drug combination regimens. Through these efforts, I hope to work towards ensuring that each patient receives the optimal treatment for curing their disease.

Hoang-Anh Vu

Graduate Student

[email protected]

I am researching translational methods to accelerate development of therapeutics across the drug development pipelines. Currently, I am working on PKPD modeling of drug delivery for optimization of TB lesion-specific dosage.

Ava Xu, PharmD

Graduate Student

[email protected]

I am interested in developing methodology that incorporates pharmacogenomics data to better predict PKPD parameters. Ultimately, the goal is to use such models to provide personalized recommendations for patients and to guide clinical trial designs.

Erwin Dreesen, MSc, PharmD, PhD

Visiting Scholar

[email protected]

I develop and apply data-driven pharmacometrics models to address unanswered questions on drug efficacy and safety, dosing strategies, and study design and interpretation. I work on various drugs in different clinical settings, including monoclonal antibodies in chronic immune-mediated inflammatory diseases and antimicrobials in children and critically ill patients. To broaden my horizon, I currently work on model-based strategies for optimizing tuberculosis therapy.

Lorenzo Flori, MS, PharmD

Visiting Scholar

[email protected]

 

I'm focusing my attention on expanding my expertise in pharmacometrics while contributing my modelling and simulation skills to the evaluation of the efficacy and safety of two new short-course regimens with the goal of identifying optimal treatment strategies for drug-sensitive tuberculosis.

Anna Fochesato, MS

Visiting Scholar

[email protected]

I am combining machine learning algorithms and PBPK/PD models to gain insights into drug disposition and efficacy in pre-clinics and clinics. Ultimately, designed tools are instrumental in guiding go/no-go decisions on early drug development and predicting treatment responses.

Staff

Craig Shaffer

Director, Research Strategy & Operations

[email protected]

I am a dedicated and experienced problem-solver passionate about providing global-health and infectious-disease insight, innovation, and impact through data-driven modeling and decision analytics.

Alexander "Sandy" Floren

Research Data Analyst

[email protected]

My research interests lie in the development and application of computational methods for the improvement of human health and longevity, particularly in vulnerable populations. Currently I am using simulation-based approaches to investigate the impact of malnutrition on HIV and TB drug exposure in young children.

Former lab members

Who

Formerly

Now

Natasha Strydom, PhD Postdoctoral Scholar

Senior Scientist, Amgen

LinkedIn

Kendra Radtke, PharmD Graduate Student

Clinical Pharmacology and Therapeutics Fellow in the Butte Lab at UC San Francisco

LinkedIn

Hwi-yeol (Thomas) Yun, PhD

Visiting Scholar

Associate Professor, College of Pharmacy, Chungnam National University

ORCID

Huy Ngo, PharmD, PhD Postdoctoral Scholar

Genentech-CERSI Clinical Pharmacology Fellow

LinkedIn

Maria Garcia-Cremades Mira, PhD Postdoctoral Scholar

Assistant Professor in the School of Pharmacy in la Universidad Complutense de Madrid

LinkedIn

Isaac Cohen, PharmD T32 Clinical Pharmacology Fellow Clinical Pharmacologist at Denali Therapeutics
Leah Gonzalez Jarlsberg Research Data Analyst Research Analyst at UCSF Pulmonary & Critical Care Division
Veronika Westergren Visiting Scholar Graduate student at Uppsala University
Nan Zhang, PhD Academic Coordinator Senior Clinical Pharmacokineticist at AstraZeneca
Priya Jayachandran, PharmD, MS Clinical Pharmacology Fellow Pharmacometrician at Pfizer
Peter Lu Administrative Analyst Research Data Analyst at UCSF
Amelia Deitchman, PharmD, PhD Clinical Pharmacology Fellow T32 Clinical Pharmacology Fellow at UCSF
Daniel Chan, PhD Postdoctoral Scholar Scientist at BioMarin Pharmaceutical Inc
William Fox, MS Research Data Analyst Computer Vision Engineer at Presto
Sarah Shaffer, MA Writer Web & Content Editor at The Wonder Kid
Katarina Vucicevic, PhD Visiting Scholar Assistant Professor at University of Belgrade
Michael Martin, PhD Postdoctoral Scholar Associate at Prescient Healthcare Group

Ron Keizer, PhD

Postdoctoral Scholar and Research Scientist

CSO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing

Sirj Goswami, PhD

PhD student in Pharmaceutical Sciences and Pharmacogenomics

CEO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing

Jennifer Hibma, PharmD

Postdoctoral Scholar

Quantitative clinical pharmacologist at Pfizer

Yookhwan Noh, PhD

Postdoctoral Scholar

Assistant professor at Ulsan University Hospital

Sneha Gupta, PhD

Clinical Pharmacology Fellow

Clinical pharmacologist at Gilead Sciences, Inc.

Jodi Parikh, PhD

Visiting Scholar

Postdoc at Rutgers New Jersey Medical School

Allison Komirenko

Visiting Scholar

Biotech Clinical Research Fellow at Achaogen

Viktoria Grahnen, MSc Junior Specialist Labeling Strategist Manager at AbbVie
Malte Larsen, MSc Junior Specialist PhD Student at University of Copenhagen
John Fors, MS, NP-C Specialist Nurse Practitioner at Stanford Health Care
Desiree Legetth, MSc Junior Specialist Quality Assurance Officer at AstraZeneca
Niels Erik Olesen, PhD Junior Specialist Postdoc at Center for Research, University of Copenhagen
Ana Kalezic, MSc Junior Specialist PhD student at Uppsala University
Benjamin Guiastrennec, PharmD, MS Visiting Graduate Student

PhD Student at Uppsala University

Yusi Chen Visiting Graduate Student Graduate Student at Tsinghua University

Imke Bartelink, PhD

Clinical Pharmacology Fellow

Senior Pharmacometrician at MedImmune
Daniel Chan, PhD Postdoctoral Scholar Scientist at BioMarin Pharmaceutical Inc
Andrew Gewitz, PhD Postdoctoral Scholar

Clinical Pharmacologist at Regeneron

Stella Belonwu, BS Graduate Student Graduate Student at UCSF