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Who

Research interests

Principal investigator

Savic

Rada Savic, PhD

Principal Investigator

[email protected]

I work on methodological advancement and application of systems pharmacology models to drug development and therapy optimization problems in tuberculosis (TB), HIV, oncology, and diabetes.

Lab members

Strydom

Natasha Strydom, PhD

Postdoctoral Scholar

[email protected]

I am involved in modeling preclinical data with a current focus on emergence of antimycobacterial resistance. My work aims to integrate with translational models to predict improved treatment outcomes in patients with tuberculosis.

Maria Garcia-Cremades Mira, PhD

Postdoctoral Scholar

[email protected]

My work consists of developing population PK/PD models using big data and new methodologies to optimize drug treatment. I am currently focused on HIV prevention in populations at high risk of infection.

Ali Mohamed Ali, PhD

Postdoctoral Scholar

[email protected]

I am working on development of clinical mechanistic PKPD-resistance models for malaria prevention and treatment. I want to use physiological based pharmacokinetic model to aid dose optimization in children.

Chores Wang, PhD

Postdoctoral Scholar

[email protected]

My research interests lie in the application of computational strategies to refine the relationship between mouse and human PK/PD. Currently, I am working on a translational mouse-to-human PK/PD model of tuberculosis treatment for regimen optimization and better outcomes prediction in Phase 2 clinical studies and beyond. My ultimate goal is to use translational modeling to help bridge preclinical-clinical divide.

Erika Wallender, MD

Assistant Professor, Department of clinical Pharmacy

[email protected]

I am interested in improving how antimalarials are used for malaria treatment and prevention in pregnant women and children by using PK/PD modeling to relate antimalarial drug exposure to toxicity, clinical and preventive efficacy, and drug resistance. Our clinical work is conducted in a collaboration between UCSF and the Infectious Diseases Research Collaboration in Kampala, Uganda.

Priya Jayachandran, PharmD, MS

Clinical Pharmacology Fellow

[email protected]

I develop population pharmacokinetic/pharmacodynamic models to describe the pharmacology of tenofovir in humans and animals for HIV prevention. I support Phase I/II/III clinical trial design for pediatric populations evaluating the safety and efficacy of anti-tuberculosis agents.

Isaac Cohen, PharmD

T32 Clinical Pharmacology Fellow

[email protected]

I am currently working on building population pharmacokinetic models of tuberculosis drugs and starting new retrospective analyses in the area of post-operative pain management. I am interested in neglected diseases and new models of therapy in psychiatry through innovative medications like MDMA and ketamine.

Zhang

Nan Zhang, PhD

Academic Coordinator

[email protected]

I am creating a pharmacometric framework to evaluate clinical trial data on predictive biomarkers by identifying the different limitations of a typical Phase 2 study setting that could result in data analysis limitations through simulations using PK-biomarker-PD models.

Janice Goh

Joint Graduate Student with the Turnbaugh Lab

[email protected]

I am interested in the involvement of the microbiome in host gene expression and how these gene changes can affect host metabolism and clearance. I utilize a variety of experimental methods including microbiology, gnotobiotics and next generation sequencing as well as computational methods like PK modeling to answer this question.

Imperial

Marjorie Imperial

Graduate Student

[email protected]

I am developing computational models that investigate the variability observed in drug response. Ultimately, the goal is to apply these models to provide personalized medicine for improved diagnosis, therapies, and prognosis of diseases.

Emma Hughes

Graduate Student

[email protected]

I am using computational models to investigate the effects of variables such as malnutrition and HIV status on malaria chemoprevention and treatment strategies in children and pregnant women. Ultimately, our goal is to deliver an optimized dosing algorithm for children and women of all ages, weights, and nutritional statuses leading to cure and prevent malaria in every patient.

Kendra Radtke, PharmD

Graduate Student

[email protected]

I am using computational methods to understand how patient and disease characteristics can predict drug exposure and response. I plan to use this information to develop precision dosing algorithms that can be applied in clinical practice.

Jackie Ernest

Graduate Student

[email protected]

I am developing translational tools to better predict clinical outcomes using preclinical data. Currently, I am using a rabbit model of tuberculosis to rank drugs and optimize dose for lesion-centric efficacy and sterilization.

Vincent Chang

Graduate Student

[email protected]

I am using computational methods to investigate novel tuberculosis biomarkers or combinations of biomarkers that can adequately monitor disease progression, follow early treatment response, and predict long term clinical outcomes.

Leah Gonzalez Jarlsberg

Research Data Analyst

[email protected]

I am a veteran in public health epidemiological research, primarily in the areas of tuberculosis, HIV, pneumonia, and asthma. I provide support to the Savic Lab team in statistical methods and good practice data management.

Craig Shaffer

Research Data Analyst

[email protected]

I am a dedicated and experienced problem-solver passionate about providing global-health and infectious-disease insight, innovation, and impact through data-driven modeling and decision analytics.

Staff

Lu

Peter Lu

Administrative Analyst

[email protected]

 

Former lab members

Who

Formerly

Now

Amelia Deitchman, PharmD, PhD Clinical Pharmacology Fellow T32 Clinical Pharmacology Fellow at UCSF
Daniel Chan, PhD Postdoctoral Scholar Scientist at BioMarin Pharmaceutical Inc
William Fox, MS Research Data Analyst Computer Vision Engineer at Presto
Sarah Shaffer, BA Writer Web & Content Editor at The Wonder Kid
Katarina Vucicevic, PhD Visiting Scholar Assistant Professor at University of Belgrade
Michael Martin, PhD Postdoctoral Scholar Associate at Prescient Healthcare Group

Ron Keizer, PhD

Postdoctoral Scholar and Research Scientist

CSO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing

Sirj Goswami, PhD

PhD student in Pharmaceutical Sciences and Pharmacogenomics

CEO and co-founder at Insight-Rx, a startup focused on using pharmacometrics for precision dosing

Jennifer Hibma, PharmD

Postdoctoral Scholar

Quantitative clinical pharmacologist at Pfizer

Yookhwan Noh, PhD

Postdoctoral Scholar

Assistant professor at Ulsan University Hospital

Sneha Gupta, PhD

Clinical Pharmacology Fellow

Clinical pharmacologist at Gilead Sciences, Inc.

Jodi Parikh, PhD

Visiting Scholar

Postdoc at Rutgers New Jersey Medical School

Allison Komirenko

Visiting Scholar

Biotech Clinical Research Fellow at Achaogen

Viktoria Grahnen, MSc Junior Specialist Labeling Strategist Manager at AbbVie
Malte Larsen, MSc Junior Specialist PhD Student at University of Copenhagen
John Fors, MS, NP-C Specialist Nurse Practitioner at Stanford Health Care
Desiree Legetth, MSc Junior Specialist Quality Assurance Officer at AstraZeneca
Niels Erik Olesen, PhD Junior Specialist Postdoc at Center for Research, University of Copenhagen
Ana Kalezic, MSc Junior Specialist PhD student at Uppsala University
Benjamin Guiastrennec, PharmD, MS Visiting Graduate Student

PhD Student at Uppsala University

Yusi Chen Visiting Graduate Student Graduate Student at Tsinghua University

Imke Bartelink, PhD

Clinical Pharmacology Fellow

Senior Pharmacometrician at MedImmune
Daniel Chan, PhD Postdoctoral Scholar Scientist at BioMarin Pharmaceutical Inc
Andrew Gewitz, PhD Postdoctoral Scholar

Clinical Pharmacologist at Regeneron

Stella Belonwu, BS Graduate Student Graduate Student at UCSF