UCSF

Clinical TB: Nonlinear Mixed-Effects Modeling of Rifapentine PK and PD

This project centers on the use of model-based approaches to study rifapentine’s pharmacokinetics and pharmacodynamics - specifically, characterization PK and clinical predictors of poor outcome. It also includes an evaluation of the relationships among rifapentine plasma concentration and other predictors on the magnitude of rifapentine autoinduction of clearance.